Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associat

Symmetry-breaking charge separation in molecular materials has attracted increasing attention for optoelectronics based on single-material active layers. To this end, Fe(III) complexes with particularly electron-donating N-heterocyclic carbene ligands offer interesting properties with a 2LMCT excited state capable of oxidizing or reducing the complex in its ground state. In this Communication, we

In her own time, Anne Brontë the writer was regarded as inferior to the two older “Bells”, largely because of the perceived slightness of her first novel and the alleged coarseness and brutality of her second. For the next hundred years, it was accepted that she was a pale second-rater in relation to her sisters. That image has now been discarded; but the notion that Anne Brontë was not quite her

Soil is an interface of the lithosphere, biosphere, hydrosphere and atmosphere that provides a habitat for microbial growth. The microbial biomass forms an integral part of the soil. The physiological potential and diversity of the microbial communities in soils are strongly associated with the physicochemical properties of soils. The biotic and abiotic characteristics determine the structure and

Markis Claes Lagergren är en av den nyare svenska katolska kyrkohistoriens kanske märkligaste konvertiter. Han har i memoarverket "Mitt livs minnen" från 1920-talet skildrat sin konversion och sitt liv fram till 35-årsåldern, alltså perioden 1853 till 1887. Memoarerna bygger på hans dagboksanteckningar, vilka för den följande perioden utgivits i urval och som i original finns i hans samling på Nor

Dimensionality reduction is an Exploratory Data Analysis (EDA) approach allowing for fast visualization of high-dimensional data and the possibility of discovering hidden systematic patterns within a data set. While linear dimensionality reduction techniques, such as Principal Component Analysis (PCA), are considered the golden standard in many areas of data science, they seem to be inadequate for

This work is focused on the modelling of experimental behaviour of a bone-shape sample made of aluminium alloy AW5083 under tension. This behaviour involves propagating instabilities, namely Lueders bands and the Portevin–Le Chatelier effect. A series of experiments was performed at room temperature for three loading rates, showing the instabilities and failure. In the paper a large strain thermov

Friction characteristics and wear of sheet-bulk metal forming tools featuring microstructured surfaces are simulated on the mesoscale. Computational homogenisation is used for surface cut-outs on which the structures are geometrically resolved and where friction laws model lower scale roughness. Two approaches are presented for the modelling of wear. A dissipation based Archard model is implemente

Background and objective Low-density computed tomography (LDCT) improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data. Hence, accurate diagnosis of early-stage lung cancer remains challenging. The purpose of the study was to assess the feasibility of using circulating tumour cells (CTCs) to differentiate malignant from benign pulmonary nodules. Mate

This study explores the potential benefits of combining a wave-shaped piston geometry with post injection strategy in diesel engines. The wave piston design features evenly spaced protrusions around the piston bowl, which improve fuel-air mixing and combustion efficiency. The ‘waves’ direct the flames towards the bowl center, recirculating them and utilizing the momentum in the flame jets for more

Circular economy (CE) has been of utmost interest in the industry and research community in the preceding years. However, CE is still a nascent research field in the built environment context. As technological advances within CE are slowing, the incorporation of business models into the concept is deemed important to achieve the necessary transition. Circular business models within the built envir

En analys av intervjuer som genomförts på Statens institutionsstyrelse LVM-hem i samband med att en person tvångsomhändertagits jmf LVM. Analysen är ett vetenskapligt underlag till SOU 2023:5 Från delar till helhet. Tvångsvården som en del av en sammanhållen och personcentrerad vårdkedja.

Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological life. There are three isozymes of nitrogenase, differing in the composition of the active site, viz., Mo, V, and Fe-nitrogenase. Recently, the first crystal structure of Fe-nitrogenase was presented. We have performed the first combined quantum mechanical and molecular mechanical (

En systematisk genomgång av internationella vetenskapliga studier inom tvångsvård av personer med beroende.

The construction industry has a great impact on the environment but there is a great potential for improvements. In the era of climate change, sustainable construction methods and ecological solutions are required to improve energyefficiency, and to decrease the environmental impact of housing development. Circular Economy is considered a feasible solution to global sustainability issues and relat

This article analyses the competence shift in EU competition law, with a particular focus on the digital era and the EU’s institutional dimension. As will be argued, the latter is expanding by means of new legislation in the Digital Single Market. Particularly Article 114 TFEU is employed as a legal base for this purpose, which essentially harmonises and pre-empts Member States’ action in this are

While the role of grandparents has increasingly been explored, the position of being a grandchild is under-researched. Recognising the active role of children in intergenerational care relationships, we analyse narratives of being a grandchild in Sweden in the 1940s–1950s, the 1970s–1980s, and today. Interviews with 63 participants of both genders show how conditions for care-doings change in resp

En studie av hur föreställningsförmågan, det inre seendet, uppmuntrades av några Vadstena-predikanter på 1400-talet. Framför allt tar artikeln upp en predikan över den Apostoliska trosbekännelsen, vilken kopplas samman med ädelstenarna i den Heliga Stadens grundmurar i Uppenbarelseboken. Artikelförfattaren gör en koppling till ett unikt smycke, det s k Motalaspännet.