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Gröna narrativ och segregerande bostadspolitik: En undersökning av problemrepresentationer i stadsplaneringsdokument rörande Köpenhamns hållbara utveckling

The study critically examines the image of Copenhagen as a “sustainable”, “inclusive” and “livable” city, specifically in relation to the political initiative known as the “ghetto law” – a social mixing policy introduced in 2018 aimed at creating a “balanced” population, combating crime, and preventing the formation of “parallel societies”. The study operates under the premise that governance is s

“Den förlorade generationen” - En kvalitativ textanalys om hur de ungas medverkan i gängkriminalitet konstrueras i Aftonbladet.

This study examines how Aftonbladet, one of Sweden’s most widely read tabloid newspapers, constructs and portrays youth gang crime in Stockholm’s Järva area. The study explores the dominant discourses shaping public perception and policy responses through a qualitative text analysis of 24 articles published between 2019 and 2023. Additionally, the role of social media in reinforcing these narrativ

Skolkuratorers roll och strategier för elevers existentiella frågor

The Swedish government's new interest in existential health's impact on the population, alongside the uncertain professional role of the school social worker (SSW), motivates research on their discretion and potential within the subject of existential health. How Swedish schools contribute to students' existential health is under investigation and there are a couple of initiatives in d

Skånska småstadskommuner söker hjälpbehövande medborgare En kritisk diskursanalys utav missbruks- och beroendeinformationen på skånska kommuners hemsidor

The Swedish system of helping with addiction-related problems is based upon municipalities' and regional hospitals' lawful responsibilities towards its citizens and patients. This thesis looks at five of the southernmost regions of Skånes municipalities' webpages, that serve to inform and attract people who have issues with substance abuse and the side effects this has on their close o

Mobility and Cultural Constraints in E.M. Forster’s Maurice and Stephen Spender’s The Temple: Portrayals of Homosexuality in Early 20th-Century Literature

E.M. Forster’s Maurice (1971) and Stephen Spender’s The Temple (1988) were written at the beginning of the 20th century and they both portray narratives of what life could look like for men who experienced attraction towards other men at the time. In this essay I examine how homosexuality is represented in Maurice and The Temple, and in what ways the portrayals of homosexuality in the two novels r

The rise of data-driven microscopy powered by machine learning

Optical microscopy is an indispensable tool in life sciences research, but conventional techniques require compromises between imaging parameters like speed, resolution, field of view and phototoxicity. To overcome these limitations, data-driven microscopes incorporate feedback loops between data acquisition and analysis. This review overviews how machine learning enables automated image analysis

Prenatal PFAS exposure associates with DXA assessed markers of adiposity in 7-year-old children from the Odense Child Cohort

The global increase in childhood overweight and obesity presents significant public health concerns due to its long-term health implications. Emerging evidence suggests that exposure to endocrine disrupting chemicals, such as per- and polyfluoroalkylated substances (PFAS), may be obesogenic and contribute to adiposity. This study aimed to investigate the association between prenatal PFAS exposure

T granules in human platelets function in TLR9 organization and signaling

Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link the innate and adaptive immune responses during infectious inflammation and atherosclerotic vascular disease. In this paper, we show that the TLR9 transcript is specifically up-regulated during pro-PLT production and is distributed to a novel electron-dense tubular system-related compartment we have named the

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that ITP is associated with a peripheral deficiency of tolerance-inducing CD4+CD25+FoxP3+ T regulatory cells (Tregs). Using a murine model of ITP, we analyzed Tregs in the spleen and thymu

HLA alloimmunization against platelet transfusions : pathophysiology, significance, prevention and management

Approximately five decades ago, alloimmunization to human leukocyte antigens (HLA) and platelet refractoriness were recognized as potentially serious complications of platelet transfusions. The mechanisms that result in stimulating immunity against blood products are still incompletely understood but are related to both the composition of the donor product transfused and the immune status of the r

Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

T-helper 1 polarization in patients with primary immune thrombocytopenia (ITP) is well documented. However, the genetic contribution to this imbalance remains unclear. To address this question, we selected six candidate single nucleotide polymorphisms within cytokine or cytokine receptor genes for association testing among Caucasian adults. Patients from the United Kingdom Adult ITP Registry were

Management of immune thrombocytopenic purpura in children : potential role of novel agents

The treatment of immune thrombocytopenic purpura (ITP) in children is controversial, requiring individualized assessment of the patient and consideration of treatment options. If the platelet count is >10 000/μL and the patient is asymptomatic, a 'watch and wait' strategy is appropriate since most children with ITP will recover completely without pharmacotherapy. If therapy is indicated because of

Platelets and the immune continuum

Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists probably don't think about platelets every day, and may even consider these cells to be 'nuisances' in certain in vitro studies. However, it is becoming increasingly clear that platelets have inflammatory functions and can influence both innate and adaptive immune responses. Here, we discuss the mechanisms

Platelets and innate immunity

Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active role in both innate and adaptive immunity. For example, platelet adhesive interactions with leukocytes and endothelial cells via P-selectin can lead to several pro-inflammatory events, inclu

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

Immune thrombocytopenia (ITP) is a bleeding disorder characterized by antibody-opsonized platelets being prematurely destroyed in the spleen, although some patients with ITP may have a cell-mediated form of thrombocytopenia. Although several animal models of ITP have been developed, few mimic primary chronic ITP nor have any shown cell-mediated platelet destruction. To create this type of model, s

Civil Defence (Re)Emerged : A Multi-Level Perspective on Policy Developments in Post-Crimea Europe

Denna avhandling undersöker (åter)uppbyggnaden av civilt försvar i Europa efter Rysslands annektering av Krim 2014. Mer specifikt analyserar den befintliga uppfattningar om civilt försvar och hur dessa formas i ett flernivåsammanhang, med fokus på samspelet mellan nationella, regionala och internationella institutioner. Genom ett diskursivt institutionellt perspektiv betonar avhandlingen den dynamThis dissertation examines the (re)emergence of civil defence in Europe in the aftermath of Russia's annexation of Crimea in 2014. More specifically, it investigates the existing conceptions of civil defence and how these are shaped in a multi-level institutional context, focusing on the interplay between national, regional, and international levels. Through the lens of discursive institutionalism

Antibiotic prophylaxis and incidence of infection following elbow arthroplasty : a nationwide study

BACKGROUND AND PURPOSE: Periprosthetic joint infection (PJI) after elbow arthroplasty is a serious complication. Evidence of the best antibiotic prophylaxis for elbow arthroplasty is lacking. We aimed to investigate the regimens presently used in Sweden, incidence of PJI, and the bacteria most frequently found in elbow PJI.METHODS: A questionnaire was sent out to all Swedish units performing elbow

Integrating machine learning with process-based glacio-hydrological model for improving the performance of runoff simulation in cold regions

Hydrological modelling is essential for effective water resources management, as it represents complex physical processes through mathematical equations to improve our understanding of the water cycle. FLEXG is a glacio-hydrological model that has been successfully applied and found to perform well in glacierized regions. This study seeks to improve the capability of classical FLEXG model for glac