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Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor intrinsic features are associated with clinical response at baseline. However, we need to further understand the molecular changes occurring during development of ICB resistance. Here, we collect biopsies from a cohort of 44 patients with melanom
Consumers are increasingly asked to “empty out their closets,” to “de-clutter” or in other ways detach themselves from the textile surplus of their wardrobes. In this article, fashion is examined as a process of detachment. Building on ethnographic wardrobe interviews, wardrobe clearances and group discussions with consumers, detachment is viewed as a fundamental, yet underexamined, process of fas
The enhanced role given to innovation in capitalist societies has resulted in a development where even matters such as gender equality are assessed and rewarded based on their innovation potential. Markets, innovations and companies are believed to possess and offer solutions to gender inequalities, a development that relies on the commodification of gender equality. This paper is based on an ethn
Over the last 50 years, there has been significant development of qualitative research and related methods in healthcare. Theoretical frameworks support researchers in selecting appropriate research approaches, procedures and analytical tools. However, the implications of the choice of theory are sparsely elucidated. Based on a text excerpt from a public debate article, the study aimed to show how
Study region: Finland divided into three subregions, each representing different environmental conditions. Study focus: This study investigates long-term changes in unregulated river discharge. Trends in high- and low-flow event volumes, magnitudes, timings, and frequencies are analysed across 36 gauging stations in 19 watershed areas from 1911 to 2021. The average measurement period for discharge
BackgroundMalignant hyperthermia (MH) is a rare pharmacogenetic disorder that can lead to a life-threatening reaction during general anaesthesia with triggering agents. Prompt life-saving treatment includes the immediate administration of the antidote dantrolene. This study investigated Swedish healthcare providers' awareness and adherence to guidelines and recommendations with respect to MH and w
The aim of this paper is to shed light on the reasons found in the literature behind digital exclusion of migrant women and propose a new framework that can be used to further research this issue when considering emergent technologies. The literature was first reviewed to identify existing knowledge and to highlight any gaps in research. The review revealed that there is a lack of theoretical fram
BACKGROUND: Increased aortic stiffness (arteriosclerosis) is associated with early vascular aging independent of age and sex. The underlying mechanisms of early vascular aging remain largely unexplored in the general population. We aimed to investigate the plasma metabolomic profile in aortic stiffness (vascular aging) and associated risk of incident cardiovascular disease and mortality.METHODS AN
Moths (Lepidoptera) are some of the most economically important pests in human agriculture. Conventional insecticides used for management promote insecticide resistance in addition to cause human- and environmental harm. This emphasises an inescapable need for sustainable alternatives and integrated practices. Moths rely on species-specific female-emitted sex pheromones for communication and repro
Quantum entanglement between the degrees of freedom encountered in the classical world is challenging to observe due to the surrounding environment. To elucidate this issue, we investigate the entanglement generated over ultrafast timescales in a bipartite quantum system comprising two massive particles: a free-moving photoelectron, which expands to a mesoscopic length scale, and a light-dressed a
Over the last years metal halide perovskites have demonstrated remarkable potential for integration in light emitting devices. Heterostructures allow for tunable bandgap depending on the local anion composition, crucial for optoelectronic devices, but local structural effects of anion exchange in single crystals is not fully understood. Here, we investigate how the anion exchange of CsPbBr3 nanowi
This thesis studies a period of intense crisis and creativity in British media, society, and culture, when the settled outcome of the Second World War (WW2) was perceived to be disintegrating. The post-world-war order was becoming an ‘order in ruins’. The thesis centres on a far-reaching analysis of the making of The World at War (WAW) in the early 1970s. A hugely popular televised documentary ser
När forskare blickar ut i universum ser de överallt spåren av en stor mängd osynlig massa. Massan finns där men det går inte att se den. Ungefär 80% av all massa i universum beräknas bestå av denna "mörka materia". Det är som att mänskligheten står på stranden och blickar ut över havet utan att veta vad vatten är. I partikelfysik studeras universums minsta beståndsdelar, elementarpartiklarna, för The high event rate delivered by the Large Hadron Collider (LHC) provides experiments with opportunities for new discoveries as well as challenges related to the large amounts of data recorded. Overcoming this requires innovative techniques in the three topics of this thesis: Data acquisition, data analysis, and data compression.In the data taking period of 2015-2018, the ATLAS experiment received
Efficient techniques for separating target cells from undiluted blood are necessary for various diagnostic and research applications. This paper presents acoustic focusing in dense media containing iodixanol to purify peripheral blood mononuclear cells (PBMCs) from whole blood in a label-free and flow-through format. If the blood is laminated or mixed with iodixanol solutions while passing through
