In patients with severe haemophilia, spontaneous bleeding into joints initiates a sequence of events culminating in disabling arthropathy. Early evidence from Sweden suggested that clotting factor prophylaxis improved patient outcomes. Recent randomized, controlled trials comparing prophylaxis with on-demand treatment have definitively shown that prophylaxis reduces bleeding and improves joint out

Objective:We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality.Subjects and methods:Among 22 799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabet

PURPOSE Chronic myeloid leukemia (CML) management changed dramatically with the development of imatinib mesylate (IM), the first tyrosine kinase inhibitor targeting the BCR-ABL1 oncoprotein. In Sweden, the drug was approved in November 2001. We report relative survival (RS) of patients with CML diagnosed during a 36-year period. PATIENTS AND METHODS Using data from the population-based Swedish Can

The main objective of this paper is to examine how exogenous technological progress, in terms of an increase in energy efficiency, affects consumption choice by Swedish households and thereby emissions of carbon dioxide (CO2), sulphur dioxide (SO2) and nitrogen oxide (NOx). The aim of the paper is closely related to the discussion of what is termed the “rebound effect”. To neutralise the rebound eThe main objective of this paper is to examine how exogenous technological progress, in terms of an increase in energy efficiency, affects consumption choice by Swedish households and thereby emissions of carbon dioxide (CO2), sulphur dioxide (SO2) and nitrogen oxide (NOx). The aim of the paper is closely related to the discussion of what is termed the “rebound effect”. To neutralise the rebound e

Alpha-synuclein (alpha-syn) aggregation is central to neuropathological changes in Parkinson's disease. The aggregates spread within the central nervous system according to a very predictable pattern. A prion-like transmission of alpha-syn aggregates has been recently proposed to explain this propagation pattern. First, we review the growing evidence for such a mechanism. This process is likely to

The Arctic Ocean Expedition of 2001 (AOE-2001) to the central Arctic mostly north of latitude 85°N was conducted to study marine life forms and their products in water and ice, how their products may get into the air, the evolution of the particles produced, and their growth up to sizes large enough for activation into clouds. The expedition also investigated whether these naturally generated part

Problems concerning quality and productivity in the construction sector have been a recurrent issue for many years and seem to remain in spite of various initiatives for resolving them. This situation is a result of human action. From social sciences we know that psychological factors crucially influence action design. Knowledge of this influence seems however to be underestimated in the construct

The barrier function of the skin mainly relies on its outermost layer, the stratum corneum (SC), which is a lipid-protein composite biomaterial. In addition, SC contains a mixture of small polar compounds, the natural moisturizing factor (NMF). Most of the NMF components are solid at ambient relative humidities (RHs). We herein raise the question of what the effects of adding a mixture of chemical

Expanding service coverage and achieving universal health coverage (UHC) is a priority for many low- and middle-income countries. Though UHC is a long-term goal, its importance and relevance have only increased since the start of the COVID-19 pandemic. The first step on the road to UHC is to define and develop essential packages of health services (EPHSs), a list of clinical and public health serv

This book discusses the various aspects of smart cities and their architecture along with the application of the latest technologies, including the Internet of Things (IoT) and artificial intelligence (AI). The concept of smart cities, their development, technological advancements, and issues related to them are discussed in detail.Smart Cities: Concepts, Practices, and Applications covers numerou

Shear forces affect self-assembly processes ranging from crystallization to fiber formation. Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides and investigated in detail for Aβ42, which is associated with Alzheimer's disease. To gain mechanistic insights into the effect of mild agitation, nonseeded and seeded aggregation reactions were set up at various