AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. However, the hypothesis that CFTR has a direct role in the endocrine pancreas has no

The effect of Ca++, Mg++, K+ and SO=4, and of serum, on the activity of testis hyaluronidase in a carbonic acid-bicarbonate buffer with pH 7.4 was investigated with the turbidimetric method. The ions were added in amounts corresponding to the serum concentration of the ion in question.The turbidity of hyaluronic acid was not modified by the investigated ions nor by serum up to 0.10 ml.The hyaluron

Could an even larger push for women empowerment be a viable development strategy for developing countries? A large literature relates the bargaining power of women to improved health and education of their children (Majlesi, 2015; Qian, 2008; Bobonis, 2009; Duflo, 2003; Lundberg, Pollak and Wales, 1997). However, it remains a challenge to find a good proxy for bargaining power that truly reflects

This observational study assessed the relationship between nighttime, early-morning and daytime chronic obstructive pulmonary disease (COPD) symptoms and exacerbations and healthcare resource use. COPD symptoms were assessed at baseline in patients with stable COPD using a standardised questionnaire during routine clinical visits. Information was recorded on exacerbations and healthcare resource u

This thesis aims to retrace the effects of a traditional local governance institution on contemporary development in Indonesia. In Indonesia, community decisions are either taken by means of consensus building among the citizens (in a democratic way) or by the local elite or village head (which could be characterized as oligarchic). Using data on the community level from the Indonesian Family Life

Objective: The aim was to study whether perceived environmental barriers to outdoor mobility affect changes in sense of autonomy in participation outdoors among community-dwelling older people over a two-year period. Methods: Community-dwelling people aged 75–90 years (n = 848) in central Finland were interviewed on two occasions, face-to-face at baseline and over the telephone two years later. Pe

Failure of soft tissue implants has been largely attributed to the influence of biomaterial surface properties on the foreign body response, but some implant complications, e.g. macrophage accumulation and necrosis, are still not effectively addressed with surface treatments to minimize deleterious biomaterial effects. We explored an alternative explanation for implant failure, linking biocompatib

This edited volume examines the continued viability of international human rights law in the context of growing transnational law enforcement. With states increasingly making use of global governance modes, core exercises of public authority such as migration control, surveillance, detention and policing, are increasingly conducted extraterritorially, outsourced to foreign governments or delegated

There is once again an increased demand for interventions supporting small and medium sized enterprises (SMEs) because of the widely held believe that they provide most of the jobs. In order to answer the question whether pro SME policies are justified on factual grounds the International Labour Organization (ILO) and the German Agency for International Cooperation (GIZ) came out with a new study

International refugee law is seen by many as constitutive for national refugee policy. Yet, as asylum has become politicized, many countries have adopted procedural and physical deterrence mechanisms to prevent refugees from accessing protection. The present article examines these policies, as well as the legal responses to them, as a critical case study for understanding the relationship between

This article analyses the interplay between politics and law in the recent attempts to strengthen the humanitarian commitment to saving lives in mare liberum. Despite a long-standing obligation to aid people in distress at sea, this so-called search and rescue regime has been marred by conflicts and political standoffs as states were faced with a growing number of capsising boat migrants potential

BACKGROUND: Cryopreserved hematopoietic stem cell products are widely used for certain hematologic malignancies. Dimethyl sulfoxide (DMSO) is the most widely used cryoprotective agent (CPA) today, but due to indications of cellular toxicity, changes of the cellular epigenetic state, and patient-related side effects, there is an increasing demand for DMSO-free alternatives. We therefore investigate