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TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells

Background: Apolipoprotein M (apoM) may have potential antiatherosclerotic properties. It has been reported that apoM expression could be regulated by many intracellar and extracellar factors. In the present study we further investigated regulation of apoM expression in Caco-2 cells stimulated by a liver X receptor (LXR) agonist, TO901317. Materials and methods: Caco-2 cells were cultured in the p

Partisanship, Ministers, and Biotechnology Policy

Research in public policy and political economy has provided many insights in the evolution of public resistance against genetically modified organisms (GMOs) in the last two decades. But how does the partisan composition of a government, its programmatic orientation and the allocation of cabinet offices affect policy making in this specific area? We argue that the regulation of GMOs is determined

Geographic and Habitat Origin Influence Biomass Production and Storage Translocation in the Clonal Plant Aegopodium podagraria.

Through physiological integration, clonal plants can support ramets in unfavourable patches, exploit heterogeneously distributed resources and distribute resources that are taken up over large areas. Physiological integration generally increases in adverse conditions, but it is not well known which factors determine the evolution of physiological integration. The aim of this study was to investiga

Intermittent PTH((1-34)) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures.

Intermittent Parathyroid Hormone (PTH)((1-34)) has an established place in osteoporosis treatment, but also shows promising results in models of bone repair. Previous studies have been dominated by closed fracture models, where union is certain. One of the major clinical needs for anabolic therapies is the treatment of open and high energy fractures at risk of non-union. In the present study we th

Essential multiple functions of farms in rural communities and landscapes

As farms are consolidated into larger operations and small farms close down for economic reasons, rural areas lose ecological, social and economic functions related to farming. Biodiversity and scenic, open-vista landscapes are lost as fields are left unmanaged. Social and economic benefits such as local job opportunities and meeting places disappear. Four Swedish rural communities were examined t

Att fokusera på "varandet" i en värld av görande. Stöd till personalen i ett palliativt förhållningssätt vid vård- och omsorgsboende för äldre

Popular Abstract in English Background Palliative care is an approach characterized by a holistic view of the person, which supports the individual for living with dignity and with the best possible level of wellbeing until the end of life. Earlier studies have shown that older people do not have the same access to palliative care as younger people do. One reason for this could be that it is diffiThe aim of this thesis was to study nurse assistants’ experience of palliative care and to investigate how an intervention with a focus on a palliative care approach in residential care facilities influenced the nurse assistants and their work situation. The thesis is based on two qualitative and two quantitative studies, focusing on nurse assistants working at residential care facilities for olde

Measurement of the gamma(1S) production cross-section in pp collisions at root s=7 TeV in ATLAS ATLAS Collaboration

A measurement of the cross-section for ϒ ( 1 S ) → μ + μ − production in proton–proton collisions at centre of mass energy of 7 TeV is presented. The cross-section is measured as a function of the ϒ ( 1 S ) transverse momentum in two bins of rapidity, | y ϒ ( 1 S ) | < 1.2 and 1.2 < | y ϒ ( 1 S ) | < 2.4 . The measurement requires that both muons have transverse momentum p T μ > 4 GeV and pseudora

Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts.

Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcinoma of the bladder treated with non-maintenance Bacillus Calmette-Guérin (n = 92), and the associations with adverse clinicopathological factors have been validated in another, unselected, coh

Movements of immature European Honey Buzzards Pernis apivorus in tropical Africa

Strandberg R., Hake M., Klaassen R.H.G. & Alerstam T. 2012. Movements of immature European Honey Buzzards Pernis apivorus in tropical Africa. Ardea 100: 157-162. Immature European Honey Buzzards Pernis apivorus are believed to remain in tropical Africa during the first years of their lives. We studied their movements during this period with the aid of satellite telemetry. After crossing the Sa

NADH-dependent biosensor in Saccharomyces cerevisiae: principle and validation at the single cell level.

A reporter system was constructed to measure perturbations in the NADH/NAD(+) co-factor balance in yeast, by using the green fluorescent protein gene under the control of the GPD2 promoter that is induced under conditions of excess of NADH. High fluorescence levels were obtained in a glycerol 3-phosphate dehydrogenase double deletion strain (gpd1Δgpd2Δ), which is deficient in the ability to regene

Smoking impairs human papillomavirus (HPV) type 16 and 18 capsids antibody response following natural HPV infection

The natural history of oncogenic human papillomavirus (HPV) infections results from interactions of the virus, the host, and multiple cofactors. We studied the association between humoral immune response to HPV and smoking in 191 HPV infected women prospectively. Two follow-up samples (first and last) were analysed for serum cotinine levels, IgA and IgG antibodies to HPV16 and 18, and Chlamydia tr

Staging of Lewy-related pathology in dementia

Objective: Lewy-related pathology is the characteristic feature of Parkinson's disease with and without dementia and dementia with Lewy bodies (DLB). There are two neuropathological staging systems for Lewy-related pathology commonly employed today: the staging system for Parkinson-related pathology by Braak et al., and the staging system by the Consortium on DLB. There are also several modified s

Turbo Charged Low Temperature Combustion - Experiments, Modeling and Control

Popular Abstract in Swedish Ekonomin och välfärden är starkt beroende av tillförlitlig transport och energiförsörjningsteknologi. En stor del av denna teknik bygger på användandet av förbränningsmotorer. Då dessa till antalet är så stort utgör de tillsammans en stor miljöbelastning. Därför måste det läggas stora resurser på förbättrad motorstyrning och avgasrening. En av restprodukterna från förBoth the global economy and the society in general are dependent on the availability of reliable transportation. Most transportation technology involves the use of internal combustion engines in one way or another. Because of the large numbers of internal combustion engines in use around the world, their emissions have a significant environmental impact. Therefore, considerable efforts have been i

Exploring Photoinduced Excited State Evolution in Heterobimetallic Ru(II)-Co(III) Complexes

Quantum chemical calculations provide detailed theoretical information concerning key aspects of photoinduced electron and excitation transfer processes in supramolecular donor-acceptor systems, which are particularly relevant to fundamental charge separation in emerging molecular approaches for solar energy conversion. Here we use density functional theory (DFT) calculations to explore the excite

The dung beetle dance: an orientation behaviour?

An interesting feature of dung beetle behaviour is that once they have formed a piece of dung into a ball, they roll it along a straight path away from the dung pile. This straight-line orientation ensures that the beetles depart along the most direct route, guaranteeing that they will not return to the intense competition (from other beetles) that occurs near the dung pile. Before rolling a new b