Importance: There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock. Objective: To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions. Data Sourc

The paper recommends a values-driven regeneration of research ethics for ethnography. In contrast to the current regulatory version of research ethics we propose a more subtle, field-oriented and traditional version, grounded in ethnographic experience. The paper is in three parts. The first part highlights the tacit assumptions of current systems of ethical approval for social research and their

Background: Stroke is a leading cause of acquired disability in adults worldwide, and the burden of stroke is projected to increase. Current long-term stroke outcome data including functional status, activity, and participation limitations as well as information on health-related quality of life (HRQoL) are vital for future rehabilitation and resource planning of stroke survivors. Methods: First-e

Solen skiner, det är tidigt på morgonen och det känns redan varmt i staden. En sådan dag är det många som söker svalkan, men vart ska de gå i städerna? Stadsmiljön domineras ofta av bebyggelse, gator och andra hårdgjorda ytor som kan upplevas väldigt varma. Många söker sig till områden i städer där de kan svalka sig och undkomma värmen, vilket blir allt viktigare för invånare i urbana områden och Recent years of reoccurring heatwaves in urban areas have led to an awareness of the negative effect heat can have on people and ecosystems. Trees play an important role in cooling urban areas but need to maintain their vitality to do so. Therefore, this paper aims to investigate the resilience of the tree community in Malmö from the perspective of an increased mean annual temperature (MAT). In th

Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps

In health, the human heart is able to match ATP supply and demand perfectly. It requires 6 kg of ATP per day to satisfy demands of external work (mechanical force generation) and internal work (ion movements and basal metabolism). The heart is able to link supply with demand via direct responses to ADP and AMP concentrations but calcium concentrations within myocytes play a key role, signalling bo

In this paper, we describe the extraction of all the location entries from a prominent Swedish encyclopedia from the early 20th century, the Nordisk Familjebok 'Nordic Family Book.' We focused on the second edition called Uggleupplagan, which comprises 38 volumes and over 182,000 articles. This makes it one of the most extensive Swedish encyclopedias. Using a classifier, we first determined the ca

Background: The COVID-19 pandemic has necessitated changes in European healthcare systems, with a significant proportion of COVID-19 cases being managed on an outpatient basis in primary healthcare (PHC). To alleviate the burden on healthcare facilities, many European countries developed contact-tracing apps and symptom checkers to identify potential cases. As the pandemic evolved, the European Un

Background: Acne vulgaris is a multifactorial disease of the pilosebaceous unit of human skin. Previous studies have identified an acne-associated dysbiosis of the skin microbiome. Objectives: This dysbiosis was mainly determined for Cutibacterium acnes. However, detailed analyses combining qualitative and quantitative aspects are scarce, also regarding the possible contribution of other skin bact

Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a

We investigate sequential two-stage admission systems with public and private schools. A sequential notion of truthfulness, called straightforwardness, is introduced. Contrary to one-stage systems, sequentiality leads to a trade-off between the existence of a straightforward equilibrium and non-wastefulness. We identify the unique set of rules for two-stage systems that guarantees the existence of

Objective: A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. We aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. The long follow-up needed to assess s

An issue of inclusionary language use in France has been debated since the 1980’s. Some French actors are in strong opposition to the language policy being changed, others are not. Actors such as linguists-lexicographers, members of the Académie françias, writers and politicians have contributed to the media discussions that are in focus of my research. Applying theoretical perspectives on languag

This thesis examines the image of China in the German media after the full-blown Russian-Ukrainian war. Due to the increasing importance of China’s economic and political influence in Germany and Europe, the selection of the research sources will primarily focus on the economic and political aspects. In terms of research methodology, this thesis adopts a combination of thematic research, qualitati

The thesis explores the de-Russification process in Ukraine since the 2022 Russian invasion using the case study of P. I. Tchaikovsky and the Ukrainian National Tchaikovsky Academy of Music. Students, staff, and alumni have protested the inclusion of the Russian composer’s name, but the governing body of the conservatory has repeatedly kept the name. Each side of the debate references different hi

This thesis attempts to describe how Right-Wing Populist Parties (RWPPs) adapt their populist rhetoric after reaching power. This research takes the case of Italy, where two RWPPs – Fratelli d’Italia (FdI) and Lega – formed a coalition government with the mainstream party Forza Italia after their alliance won the 2022 legislative elections. Through the holistic grading (a form of content analysis)

Democracy has been the cornerstone of the European Union since its foundation, however, since Viktor Orbán and his Fidesz party took office, what has been happening in Hungary is greatly undermining the democratic values in the EU. In that context, this thesis seeks to examine what results in the democratic backsliding in a country which was once one of the most successful stories of democratizati

Fish fins are remarkable devices of propulsion. Fin morphology is intimately linked to locomotor performance, and hence to behaviours that influence fitness, such as foraging and predator avoidance. This foreshadows a connection between fin morphology and variation in predation risk. Yet, whether prey can adjust fin morphology according to changes in perceived risk within their lifetime (a.k.a. pr