A10K (A=alanine, K=lysine) model peptides self-assemble into ribbon-like β-sheet aggregates. Here, we report an X-ray diffraction investigation on a flow-aligned dispersion of these self-assembly structures. The two-dimensional wide-angle X-ray scattering pattern suggests that peptide pack in a two-dimensional oblique lattice, essentially identical to the crystalline packing of polyalanine, An (fo

Boken är en översikt över analytisk musikfilosofi rörande meningsaspekter och värde samt egna ställningstagande i förhållande till dessa frågor.

The aggregation of the 11 residue long NACore peptide segment of α-synuclein (68-GAVVTGVTAVA-78) has been investigated using a combination of cryogenic transmission electron microscopy (cryo-TEM), small- and wide-angle X-ray scattering, and spectroscopy techniques. The aqueous peptide solubility is pH dependent, and aggregation was triggered by a pH quench from pH 11.3 to approximately pH 8 or 6,

We analyze the size evolution of pebbles accreted into the gaseous envelope of a protoplanet growing in a protoplanetary disk, taking into account collisions driven by the relative sedimentation speed as well as the convective gas motion. Using a simple estimate of the convective gas speed based on the pebble accretion luminosity, we find that the speed of the convective gas is higher than the sed

Bees exemplify flights under bright sunlight. A few species across bee families have evolved nocturnality, displaying remarkable adaptations to overcome limitations of their daylight-suited apposition eyes. Phase inversion to nocturnality in a minority of bees that co-exist with diurnal bees provides a unique opportunity to study ecological benefits that mediate total temporal niche shifts. While

We document that a high level of natural productivity of the ocean - a rich bounty of the sea - has had a positive and persistent impact on economic development since pre-industrial times until today. In addition, we document that it is the bounty of the sea of the ancestors of current populations which drives the persistent effect, not geography per se. We argue that an explanation is that a rich

Increased cancer risks are well documented in adult organ transplant recipients. However, the spectrum of malignancies and risk in the pediatric organ transplant population are less well described. We identified all solid organ transplanted patients aged

OBJECTIVES: Cancer survival rates vary widely between European countries, with differences in timeliness of diagnosis thought to be one key reason. There is little evidence on the way in which different healthcare systems influence primary care practitioners' (PCPs) referral decisions in patients who could have cancer.This study aimed to explore PCPs' diagnostic actions (whether or not they perfor

Anthropogenic land use and land cover changes (LULCC) have a large impact on the global terrestrial carbon sink, but this effect is not well characterized according to biogeographical region. Here, using state-of-the-art Earth observation data and a dynamic global vegetation model, we estimate the impact of LULCC on the contribution of biomes to the terrestrial carbon sink between 1992 and 2015. T

Using the example of the Chernobyl nuclear catastrophe, this article analyses a unique mechanism regarding the transformation of ontological security into ontological insecurity and then cultural trauma. It demonstrates how, from ontological security constructed by the Soviet ideology, Chernobyl moved to ontological insecurity understood as a breakdown in the established beliefs. By blaming the So

Encounters and interactions between healthcare professionals and patients are central in healthcare services and delivery. Encountering persons who frequently use psychiatric emergency services (PES), a complex patient group in a complex context, may be particularly challenging for healthcare professionals. The aim of the study was to explore healthcare professionals’ experiencesof such encounters

Machinery prices are a crucial part of the history of catching up, technological progress and the industrial revolution diffusion. However, the efforts to obtain an international price for capital goods have been scattered and the majority of the works dealing with this phenomena had a national scope mainly . In this paper, the authors have done an effort to homogenise the different national machi