Background: Tyrosine kinase inhibitors (TKIs) have increased survival dramatically for patients with chronic myeloid leukemia (CML), but continuous administration of these drugs may elicit long-term toxicity. Objective: To investigate the incidence of vascular events in patients with CML treated with first-and second-generation TKIs. Design: Retrospective cohort study using nationwide population-b

BACKGROUND: Long commutes by car are stressful. Most research studying health effects of commuting have summarized cross-sectional data for large regions. This study investigated whether the levels of stress and individual characteristics among 30–60 min car commuters were similar across different places within the county of Scania, Sweden, and if there were changes over time. METHODS: The study p

Distributed averaging is one of the simplest and most widely studied network dynamics. Its applications range from cooperative inference in sensor networks, to robot formation, to opinion dynamics. A number of fundamental results and examples scattered through the literature are gathered here and some original approaches and generalizations are presented, emphasizing the deep interplay between the

Governments increasingly rely on the use of market instruments to tackle climate change and help decarbonize a deeply fossil fuel-dependent economy. This dissertation examines this trend as one instance of the ‘commodification of carbon’, or the process through which emission reductions are made into commodities and then traded on the market. It engages the commodification framework and related th

Locally induced, magnetic order on the surface of a topological insulator nanowire could enable room-temperature topological quantum devices. Here we report on the realization of selective magnetic control over topological surface states on a single facet of a rectangular Bi2Te3 nanowire via a magnetic insulating Fe3O4 substrate. Low-temperature magnetotransport studies provide evidence for local

This study investigated if mental reinstatement of an encoding context during retrieval increases memory accessibility. Participants performed a cued-recall memory task where the overlap between encoding and retrieval context and the nature of context reinstatement (mental versus physical) were manipulated. Memory performance improved when the encoding-retrieval context overlapped in a comparable

The Arctic climate is projected to change during the coming century, with expected higher air temperatures and increased winter snowfall. These climatic changes might alter litter decomposition rates, which in turn could affect carbon (C) and nitrogen (N) cycling rates in tundra ecosystems. However, little is known of seasonal climate change effects on plant litter decomposition rates and N dynami

Abstract This study relates soil organic matter (SOM) characteristics to initial soil incubation carbon release from upper permafrost samples in Yedoma region soils of northeastern Siberia, Russia. Carbon (C) and nitrogen (N) content, carbon to nitrogen ratios (C:N), δ13C and δ15N values show clear trends that correspond with SOM age and degree of decomposition. Incubation results indicate that ol

Now, more than ever, we are told that ‘authenticity’ is an added value that customers want. The objective of this study is to determine what authenticity relevant for design is and whether it can be used as a standardised procedure to improve product design. In this study, industrial designers have been interviewed about their views on authenticity. This paper is a combined result of a literature Now, more than ever, we are told that 'authenticity' is an added value that customers want. The objective of this study is to determine what kind of authenticity is relevant to design, and whether it can be used as a standardised procedure to improve product design. In this study industrial designers were interviewed about their views on authenticity. The paper represents the combined result of a

Thiosphaera pantotropha is capable of simultaneous heterotrophic nitrification and aerobic denitrification. Consequently, its nitrification potential could not be judged from nitrite accumulation, but was estimated from complete nitrogen balances. The maximum rate of nitrification obtained during these experiments was 93.9 nmol min−1 mg of protein−1. The nitrification rate could be reduced by the

An oxygen microsensor in combination with mathematical modeling was used to determine the behavior of immobilized Thiosphaera pantotropha. This organism can convert ammonia completely to nitrogen gas under aerobic conditions (coupled nitrification/denitrification) and denitrifies nitrate at highest rates under anaerobic conditions. Immobilization of T. pantotropha can result in aerobic and anaerob

During substrate-limited growth, some strains of Thiosphaera pantotropha nitrify heterotrophically and denitrify aerobically. These processes are thought to be used as NADH overflow mechanisms, resulting from a restricted oxygen respiration capacity. In this study, the behavior of T. pantotropha regarding the NADH overflow in the presence of substantial concentrations of substrate was examined. Co

Pancreatic cancer is one of our most lethal malignancies. Despite substantial improvements in the survival rates for other major cancer forms, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Pancreatic cancer is usually detected at an advanced stage and most treatment regimens are ineffective, contributing to the poor overall prognosis. Herein, we review the cu

National incidence and prevalence estimates of homelessness in Canadian youth are unknown. However, a recent annual profile of shelter users in a large urban centre estimated that one in five consumers of emergency shelter services are youth. Adolescence is a period of vulnerability from developmental perspective. In their progression from childhood to adulthood, youth have multiple role transitio

This paper presents findings on the role of online traveller information services in regional public transport for olderpeople and people with functional limitations. An explanatory mixed methods design was used. A quantitative questionnairestudy of the target group’s need of traveller information and use of online traveller information services provided the basisfor a qualitative focus group stud

In this work we have investigated face verification based on deep representations from Convolutional Neural Networks (CNNs) to find an accurate and compact face descriptor trained only on a restricted amount of face image data. Transfer learning by fine-tuning CNNs pre-trained on large-scale object recognition has been shown to be a suitable approach to counter a limited amount of target domain da

A well-planned waiting area is crucial for automatic milking systems. In an enclosed waiting area, cows of different rank compete for entering the milking station and they are exposed for a variety of social interactions. Such interactions could increase standing time and delay milking, which may result in stress, lameness, impaired welfare and reduced performance. The aim was to monitor the waiti