The progression of diabetes is accompanied by increasing demand to the beta-cells to produce and secrete more insulin, requiring complex beta-cell adaptations. Functionally-active and ubiquitous non-coding RNAs (ncRNAs) have the capacity to take part in such adaptations as they have been shown to be key regulatory molecules in various biological processes. In the pancreatic islets, the function of

Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the majo

This paper presents a method to investigate the behaviour of polymers on different scales during deformation using simultaneously collected synchrotron X-ray scattering, digital image correlation (DIC) and tensile loading. The method is demonstrated through experiments made on specimens of amorphous polycarbonate. Deformation is measured in-situ, simultaneously across different scales from the mac

The ego depletion effect has been consistently replicated using the typical paradigm that consists of two consecutive tasks. However, striking contradiction exists in studies employing multiple tasks. The aim of the current study is to replicate previous studies following a similar procedure and design in a sample of participants from a non-western cultural background (Chinese), while strictly con

This article presents a study of 16 scholarly blogs with the aim to gain an in-depth understanding of what characterizes blogging as part of the scholarly communication. Eight blogs from high energy physics (HEP) and eight from digital history were closely followed. The analysis was made by employing an analytical framework based on genre theory. The results reveal common communicative purposes in

Despite the undisputed importance of organizational innovation and decades of academic research on the subject, there is surprisingly little agreement on what innovativeness is or how to achieve successful innovation in practice. Furthermore, the difference between the theory and practice is often interpreted in an ad hoc manner, which limits the potential for innovation to provide a competitive a

Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of cell-based therapies for Parkinson's disease. The mechanisms underlying these dyskinesias are not well understood, and it is not known whether they are the same as in the dyskinesias induced by L-dopa

We present a comparison of experimentally and theoretically determined osmotic pressures for various colloidal dispersions. Experimental data is collected from several different silica and polystyrene dispersions. The theoretical pressure determinations are based on the primitive model combined with the cell model, and the physical quantities are calculated exactly using Monte Carlo simulations in

Treatment with warfarin in combination with clopidogrel has been shown to reduce the incidence of major bleeding as compared to triple antithrombotic therapy (TT; warfarin, clopidogrel and aspirin). However, there are uncertainties regarding the risk for thrombosis since poor-responsiveness to clopidogrel is common. Ticagrelor is a more potent platelet inhibitor, but data supporting concurrent use

Ca/Na montmorillonite and natural Wyoming bentonite (MX-80) have been studied experimentally and theoretically. For a clay system in equilibrium with pure water, Monte Carlo simulations predict a large swelling when the clay counterions are monovalent, while in presence of divalent counterions a limited swelling is obtained with an aqueous layer between the clay platelets of about 10 A. This latte

Clear cell renal cell carcinoma (ccRCC) is by far the most common type of kidney cancer and is characterized by loss of the tumor suppressor gene von Hippel-Lindau (VHL). ccRCC patients with metastatic disease has poor prognosis and today's therapy is insufficient. The cytokine Transforming Growth Factor-β (TGF-β) has been extensively studied in tumor biology and is believed to serve a variety of

Cinnamoyl-CoA reductase (CCR), an enzyme central to the lignin biosynthetic pathway, represents a promising biotechnological target to reduce lignin levels and to improve the commercial viability of lignocellulosic biomass. However, silencing of the CCR gene results in considerable flux changes of the general and monolignol-specific lignin pathways, ultimately leading to the accumulation of variou

The safety, feasibility, and hemodynamic effects of mild hypothermia (MH) induced by transnasal cooling were studied in transcatheter aortic valve replacement (TAVR). MH is a common therapy following cardiac arrest and seems to have favorable effects in myocardial infarction and on hemodynamic stability. In TAVR, hemodynamic instability is common during rapid pacing. Twenty subjects undergoing TAV

Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good

Energy security is one of the main drivers of energy policies. Understanding energy security implications of long-term scenarios is crucial for informed policy making, especially with respect to transformations of energy systems required to stabilize climate change. This paper evaluates energy security under several global energy scenarios, modeled in the REMIND and WITCH integrated assessment mod

More than 4 orders of magnitude of cavity-linewidth narrowing in a rare-earth-ion-doped crystal cavity, emanating from strong intracavity dispersion caused by off-resonant interaction with dopant ions, is demonstrated. The dispersion profiles are engineered using optical pumping techniques creating significant semipermanent but reprogrammable changes of the rare-earth absorption profiles. Several

The objective of this paper is to demonstrate the full-scale feasibility of the phenomenological dynamic influent pollutant disturbance scenario generator (DIPDSG) that was originally used to create the influent data of the International Water Association (IWA) Benchmark Simulation Model No. 2 (BSM2). In this study, the influent characteristics of two large Scandinavian treatment facilities are st

In order to determine the cardioprotective efficacy of acute reperfusion therapy, assessed as myocardial salvage, in patients with acute coronary occlusion, the final myocardial infarct (MI) size needs to be related to the amount of ischemic myocardium during coronary occlusion, referred to as the myocardium at risk (MaR). There are currently several imaging approaches available for quantification

Biorefining of crops for production of power, transport fuels, and a diverse array of chemicals has potential for providing significant added economic value to biomass. A shift in the industrial resource base from fossil resources to biomass also requires a shift in the technology base for producing, handling, and processing of raw materials. Biotechnology will play an important role in providing