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Sphingolipid hydrolysis enzymes in the gastrointestinal tract

In the intestinal tract, there are enzymes that hydrolyze both endogenous and exogenous sphingolipids. The alkaline sphingomyelinases (SMase) of the gut and human bile have been most studied, and a major part of this chapter discusses these enzymes. It also discusses studies of ceramidase, glycosylceramidase, and the digestion of dietary sphingolipids. In the intestinal tract, a distinct enzyme th

A high-beef diet alter protein kinase C isozyme expression in rat colonic mucosa.

We recently reported that a red meat (beef) diet relative to a casein-based diet increases protein kinase C (PKC) activity in rat colonic mucosa. The purpose of this study was to further elucidate the effects of a high-beef diet on colonic intracellular signal transduction by analyzing steady-state protein levels of different PKC isozymes as well as activities of the three types of sphingomyelinas

A mutual inhibitory effect on absorption of sphingomyelin and cholesterol

Several studies have shown that there is a strong physical interaction between cholesterol and sphingomyelin (SM). The critical factor is thought to be the high degree of saturation in the very long acyl chains of SM. In this study we examined the effects of SM on cholesterol absorption in the rat and compared them with those of phosphatidylcholine (PC). Cholesterol absorption was studied by use o

Effects of phospholipids on sphingomyelin hydrolysis induced by intestinal alkaline sphingomyelinase: an in vitro study

Digestion of dietary sphingomyelin (SM) is catalyzed by intestinal alkaline sphingomyelinase (SMase) and may have important implications in colonic tumorigenesis. Previous studies demonstrated that the digestion and absorption of dietary SM was slow and incomplete and that the colon was exposed to SM and its hydrolytic products including ceramide. In the present work, we studied the influences of

Evidence for specific ceramidase present in the intestinal contents of rats and humans.

A neutral ceramidase activity stimulated by bile salt was previously identified in the intestinal content. Recently, bile salt stimulated lipase (BSSL) was found to have ceramidase activity. It is unknown whether the ceramidase activity previously found is attributable to BSSL. To address this question, we compared the behaviors of high quaternary aminoethyl (HQ) anion exchange chromatography, the

Distribution and properties of neutral ceramidase activity in rat intestinal tract

Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however, not been well investigated. Our data reveal the existence of a ceramidase (EC 3.

Integrating national Red Lists for prioritising conservation actions for European butterflies

Red Lists are very valuable tools in nature conservation at global, continental and (sub-) national scales. In an attempt to prioritise conservation actions for European butterflies, we compiled a database with species lists and Red Lists of all European countries, including the Macaronesian archipelagos (Azores, Madeira and Canary Islands). In total, we compiled national species lists for 42 coun

Geofysiker, drönare och geologer ger tillsammans en bättre bild av berget

Teknisk geologi vid Lunds tekniska högskola har i ett nyligen slutfört projekt, finansierat av Stiftelsen Bergteknisk Forskning (BeFo), undersökt om geofysiska mätningar med DCIP (kombinerade resistivitets- och IP-mätningar) kan ge bättre information om bergmassan i samband med planeringen av tunnlar och andra bergarbeten samt berguttag i bergtäkter. Resultaten bekräftar att DCIP i den undersökta

Bildliga betydelser i SAOB : Om beskrivningen av betydelseutvecklingsmekanismer analyserad ur ett kognitivt semantiskt perspektiv

Man talar ibland om bildligt språkbruk och bildliga betydelser, men vad är det för något egentligen, mer exakt? I Svenska Akademiens ordbok (SAOB) är många betydelser försedda med etiketten "bildl.". Faktum är att denna etikett förekommer mer än 40 000 gånger på ordbokens spalter. Trots det är de redaktionella anvisningarna vaga om hur den semantiska analysen av sådant språk ska genomföras. I den

MRI Perfusion Measurements using Magnetic Susceptibility Effects: : Calibration Approaches and Contrast Agent Quantification

Perfusion eller genomblödning är termer som används för att beskriva blodflödet i kroppens allra minsta kärl. Information om perfusion kan vara av stor betydelse för att ställa diagnos vid vissa sjukdomar, eftersom blodet transporterar det syre och den näring som behövs för att upprättahålla vävnadens funktion i kroppen. Ett viktigt exempel där information om perfusion kan vara till nytta för att Exchange of oxygen and nutrients between blood and tissue occurs at the capillary level of the blood system. The blood volume flow rate in the capillaries is often referred to as perfusion, and knowledge about perfusion provides important information about the function and viability of the tissue, for example, in patients with ischaemic stroke, cancer, and neurodegenerative diseases.Dynamic suscep

Embodying circularity through usable relocatable modular buildings

Purpose: Global megatrends such as urbanization and ageing of the population result in fast-paced demographic changes, which pose different types of challenges for different regions. While many rural municipalities bear the burden of under-used buildings, cities are in a hurry to develop new ones to meet new space demands. The purpose of this paper is to assess the potential of relocatable modular

Managing business networks for value creation in facilities and their external environments : A study on co-location

Purpose: The purpose of this paper is to increase understanding of the logic of business network formation among the co-located and external actors of a facility. Design/methodology/approach: The research adopts a theory-building approach through developing propositions inductively from the empirical case study on four purposefully sampled modern service station facilities. The focus is on analyzi

Connectivity, cost-efficiency, community and collaboration : The value of co-locating on a health campus

Purpose: This paper aims to increase understanding on how co-locating in a multi-firm campus setting could be of value to healthcare organizations. Design/methodology/approach: The paper presents a qualitative case study of two health campuses in Finland. The data comprises interviews with different organizations operating on the campuses, complemented by onsite observations, and analysis of archi

Housing managers key to reducing the greenhouse gas emissions of multi-family housing companies? A mixed method approach

The building industry is facing a huge challenge as the industry sector carries much responsibility of the anthropogenic climate change: activities associated with housing alone account for as much as 30% of global annual energy demand. This demand derives not only from the physical characteristics of the buildings, but from the actions of the users, both end-users and professional managers. Even

Assessing the Potential of Climate Change Mitigation Actions in Three Different City Types in Finland

As the effects of global warming have become more evident, ambitious short-term greenhouse gas emission reduction targets have been set in recent years. Many cities worldwide have adopted an active approach to climate change mitigation, but policy makers are not always knowledgeable of the true effects of their planned mitigation action. The purpose of this paper is to evaluate the effectiveness o

Role of capsule endoscopy in small bowel management

The small bowel is difficult to reach and to examine endoscopically. Video capsule endoscopy (VCE) using a wireless imaging technology was introduced 2000. VCE is an ingestible capsule camera that takes photographs during its passage throughout the gastrointestinal tract. The diagnosis of small bowel Crohn's disease is among the prime indications for VCE, as one third of patients with Crohn's dise

Dense downtown living more carbon intense due to higher consumption : A case study of Helsinki

Hindering urban sprawl is one of the main goals for contemporary urban planning. Urban density is considered crucial in climate change mitigation since it reduces automobile dependence and decreases unit sizes, for example. This letter analyzes the effect of density in a city context. In the study the Finnish capital Helsinki is divided into two areas of different urban densities: the high density

Possibilities for user-centric and participatory design in modular health care facilities

Many of today’s health care facilities are outdated and no longer efficiently support processes. The various development trends in changing health care services seem to support more frequent use of modular facilities. Modular facilities and their development, however, face the challenge of combining a customized, user-centric design for special customer needs with the rapid delivery of prefabricat