Owing to the heterogeneity in the clinical phenotype of haemophilia A and B, it is now recognized that disease severity (based on factor VIII/IX activity) may no longer be the most appropriate guide for treatment and that a 'one-size-fits-all' approach is unlikely to achieve optimal therapy. Based on the present literature and consensus views of a group of experts in the field, this article highli

Large-scale multi-species data on population changes of alpine or arctic species are largely lacking. At the same time, climate change has been argued to cause poleward and uphill range shifts and the concomitant predicted loss of habitat may have drastic effects on alpine and arctic species. Here we present a multi-national bird indicator for the Fennoscandian mountain range in northern Europe (F

Two new compounds, [(C4H9)(4)P](2)[Cu5I7], and [(C4H9)(4) P](2)[Cu5I7]center dot CH3COCH2OH were synthesized by solvolysis and their crystal structures were solved. The first compound is disordered, but the solvate represents the first example of a fully ordered [Cu5I7](2-) cluster. It displays a molecular symmetry very close to C-2. Both compounds crystallize in space group P2(1)/c. (C) 2010 Else

Dug trenches in sediment-cored drumlins on the Småland peneplain, southern Sweden, occurring intermixed with rock-cored drumlins, revealed sedimentary successions and facies suggesting that the core sediments were primarily deposited proglacially, both in glaciolacustrine settings as delta-front and more distal deeper-water sediments, and as glaciofluvial braidplain sediments. From the relationshi

We present triethylboron (TEB) as a single-source precursor for chemical vapor deposition (CVD) of BxC thin films and study its gas phase chemistry under CVD conditions by quantum chemical calculations. A comprehensive thermochemical catalogue for the species of the gas phase chemistry of TEB is examined and found to be dominated by beta-hydride eliminations of C2H4 to yield BH3. A complementary b

Until the late 1990s researcher described a new strategy and organization for MNCs. The new MNC was omnipotent in character, striving for many new competitive advantages. This paper reviews the literature and synthesizes the ideas behind this Omnipotent MNC. General themes and key organizational characteristics are identified. A survey among large Swedish companies illustrate that many of the iden

A search is presented for microscopic black holes in a like-sign dimuon final state in proton-proton collisions at root s = 8 TeV. The data were collected with the ATLAS detector at the Large Hadron Collider in 2012 and correspond to an integrated luminosity of 20.3 fb(-1). Using a high track multiplicity requirement, 0.6 +/- 0.2 background events from Standard Model processes are predicted and no

Purpose This study seeks to investigate the long-term public health burden of Hodgkin lymphoma (HL) in terms of work loss following contemporary treatment protocols and associations with established treatment complications and lymphoma relapse. Methods We identified 1,989 Swedish HL patients (1,082 with clinical information) aged 18-60 (median 33) years at diagnosis 1992-2009, and matched 1:4 to p

The recent influx of migrants and asylum seekers in Europe has drawn our attention towards the future of Schengen and European border politics. In 2014-2015 a European collaborative project called Turnstone (partly funded by the European commission) was implemented to increase control of European borders in the Baltic Sea area and to diminish trans-boundary criminality. The purpose of the project

Abstract Purpose – The purpose of this paper is to examine the growing importance of generic mobile computing for ITS (Intelligent Transportation System) development and governance. Specifically, building on theories of open innovation and pertinent examples, the paper aims to inform future ITS policymaking. Design/methodology/approach – Using a wide range of national, regional, and industry roadm

1. The mechanisms driving nonrandom assembly patterns in plant communities have long been of interest in ecological research. Competing ecological theories predict that coexisting species may either be more functionally dissimilar than expected by chance (with functional divergence' mainly reflecting niche differentiation) or be functionally more similar than expected (with functional convergence'

Genetics, epigenetics and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using genome-wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case-control cohorts. In adipose tissue from discordant twins, we found decreased expression of genes

A series of novel neutral and cationic methylpalladium complexes bearing N-alkyl-2,2'-dipyridylaldiminato ligands were prepared and characterized. In the presence of ethylene, the cationic complexes were active as dimerization catalysts, producing a mixture of 1- and 2-butenes. A Pd-ethyl pi-ethylene species was identified as the catalyst resting state by low-temperature spectroscopic and DFT stud

Pain is a key unmet need and a major aspect of non-motor symptoms of Parkinson's disease (PD). No specific validated scales exist to identify and grade the various types of pain in PD. We report an international, cross-sectional, open, multicenter, one-point-in-time evaluation with retest study of the first PD-specific pain scale, the King's PD Pain Scale. Its seven domains include 14 items, each

The self-report Drug Attitude Inventory (DAI), in 30- and 10-item versions, provides unique information of clinical relevance for monitoring treatment adherence among people diagnosed with schizophrenia. The primary purpose of this paper was to evaluate the 10-item version among patients living in sheltered housing. Data were collected among 68 persons living in sheltered housing, most of them (82

Informal (dementia) care has economic consequences throughout the health care system. Whilst the health and wellbeing of the care recipient might improve, the health of the caregiver might also change, typically for the worse. Therefore, this analysis aims to examine the association between caregiving intensity and caregivers' health and health care utilization.

Purpose: To test the potential of magnetic resonance imaging (MRI) in early detection of left ventricular (LV) dysfunction in patients with pulmonary regurgitation and normal LV ejection fraction after repair of tetralogy of Fallot. Materials and Methods: Patients (n = 18) with repaired tetralogy of Fallot and pulmonary regurgitation were prospectively recruited. Healthy volunteers (n = 10) were u