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Ageing in the human brain is a major risk factor for most neurodegenerative diseases. Yet the cell-type-specific molecular changes that contribute to this risk remain poorly understood. This thesis investigates cell-type-specific changes across multiple levels of molecular regulation and their roles in physiological and pathophysiological brain ageing. Using single-nucleus RNA sequencing of postmo
Följande paper-presentation behandlar aspekter av ett doktorandprojekt i startgroparna. Hannes Wikströms musikpedagogiska studie faller under kategorin praktiknära forskning, i och med dess ambition att bidra till att stärka band och kontaktytor mellan forskningsmiljö och Kulturskolans pedagogiska praktik, samt dess vilja att låta skolpersonalens och elevernas röster, behov och frågeställningar tj
The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,
I dagens välfärdstjänster har synen på användaren i allt högre grad förskjutits från en passiv mottagare till en aktiv deltagare i värdeskapande. Denna förskjutning återspeglas i policyreformer, organisatoriska strategier och akademisk diskurs, vilka alla i ökande grad betonar användarorientering. Inom det teoretiska ramverket Public Service Logic (PSL) framställs användarorientering som ett sätt In today’s welfare services, how the user is viewed has increasingly been shifting away from a passive recipient towards an active participant in value creation. This shift is reflected in policy reforms, organisational strategies, and academic discourse, with all of these placing a growing emphasis on user orientation. Within the theoretical framework of Public Service Logic (PSL), user orientati
High-altitude lakes and headwater streams of the Andes provide essential benefits to society, yet they remain among the least studied and most vulnerable freshwater ecosystems. These systems supply drinking water, support agriculture and grazing, regulate floods, store carbon, and hold deep cultural and spiritual value for local communities. However, climate change, land use change, water extracti
Integrating multi-modal patient data to support personalized medicine has gained a lot of interest across different health domains over the past decade. Addressing this challenge requires the development and implementation of an informed, evidence-based AI-driven decision-support system continuously maintained and updated to align with the latest clinical guidelines. A key challenge to ensure its
Selenium (Se), an important micronutrient with several biological effects, exhibits improved stability, biocompatibility, and safety through nanoparticle (NP) formulation. We present here a novel approach for producing smaller and structurally stable biogenic selenium nanoparticles (SeNPs) with bioactive coating. Poly(allylamine hydrochloride)-coated SeNPs were synthesized biogenically using Tra
Granskning av språkliga och innehållsliga val och strategier i primärt två översättningar av Axel Wallengrens "fakirtexter" till tyska respektive danska med särskilt fokus på Wallengrens s k alfabetsverser.
This paper presents hitherto unknown finds of baleen whale from Iron Age Scania. Through the peptide-based technique Zooarchaeology by Mass Spectrometry (ZooMS), we provide the first identifications of remains of humpback whale (Megaptera novaeaenglia) and fin whale (Balaenoptera physalus) in Scania and we present the first identification of North Atlantic right whale (Eubalaena glacialis) or bowh
This thesis consists of four self-contained empirical studies on how economic shocks and structural changes shape individual behavior and local outcomes.Paper I examines how military base closures affect young adults’ education and labor market outcomes. The results show that men respond by increasing tertiary education, while women experience improved short-term labor market outcomes, suggesting
As media consumption becomes increasingly individualized, people’s desire for shared cultural experiences remains. Reaction media provides one way to fulfil that need, fostering transnational community (Swan 2018) and a sense of co-presence and immediacy. In their most basic form, reaction media show people filming themselves or being filmed while reacting – viewing, eating, playing, trying out or
Sjunkande tittarsiffror och avtagande samtidsrelevans har fått många att undra om inte dagarna är räknade för tv:s late-night talkshows. Men nu verkar den förmodade nådastöten – motståndet från Trump och Maga-rörelsen – i stället gjuta nytt liv i det amerikanska 50-talsformatet.
Lyme arthritis (LA) is a recognized manifestation of Lyme borreliosis in Sweden, but data on the causative Borrelia species are limited. This study aimed to describe the demographics of LA and identify Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) genospecies present in synovial fluid (SF). Patient data were collected from the test requisition form accompanying consecutive SF samples submi
An animal possessing reversal learning ability is capable of unlearning a previously learnt association between a stimulus and a reward and learning a new contingency. It is a form of behavioural flexibility, which can be advantageous in changing environments. Serial reversal learning occurs when an animal's performance improves over repeated reversals of contingencies. In this study, we tested th
