Motor dysfunctions in Parkinson's disease are considered to be primarily due to the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Pharmacological therapies based on the principle of dopamine replacement are extremely valuable, but suffer from two main drawbacks: troubling side effects (e.g. dyskinesia) and loss of efficacy with disease progression. Transplantation of

The present study describes and compares quality of life (QoL) and factors which predict QoL among people aged 75 years and over who receive help with activities of daily living (ADLs) from formal and/or informal helpers. The subjects were living at home or in special accommodation in Sweden. A postal questionnaire was sent to a randomly selected and age-stratified sample of 8500 people. The respo

We discuss four variants of the graph colouring problem, and present algorithms for solving them. The problems are k-COLOURABILITY, MAX IND k-COL, MAX VAL k-COL, and, finally, MAX k-COL, which is the unweighted case of the MAX k-CUT problem. The algorithms are based on the idea of partitioning the domain of the problems into disjoint subsets, and then considering all possible instances were the va

This study reports effects on soil solution chemistry and plant uptake of 55 elements (Ag, Al, As, B, Ba, Be, Bi, Br, Ca, Cd, Ce, Co, Cr, Cs, Cu, Dy, Er, Eu, Fe, Gd, Ge, Hf, Hg, Ho, K, La, Li, Lu, Mg, Mn, Mo, Na, Nb, Nd, Ni, P, Pb, Pr, Rb, S, Sb, Sc, Se, Si, Sm, Sr, Tb, Th, Tl, U, V, W, Y, Yb, Zn, Zr) by raising the pH using addition of fine-grained precipitated calcium carbonate at 20 rates (yiel

The aim of this study was to characterize the reversible cerebral uptake of morphine in the pig by measuring the changing arterio-venous plasma concentration gradient over the brain. Seven pigs were anaesthetized by continuous infusions of ketamine and pancuronium and ventilated with oxygen in nitrous oxide. During and after 5-min intravenous infusions of morphine hydrochloride, blood samples were

Background: The GOLD classification of COPD severity introduces a stage 0 ( at risk) comprising individuals with productive cough and normal lung function. The aims of this study were to investigate total mortality risks in GOLD stages 0 - 4 with special focus on stage 0, and furthermore to assess the influence of symptoms of chronic bronchitis on mortality risks in GOLD stages 1 - 4. Method: Betw

Clear cell renal cell carcinoma (ccRCC) is the most common type of cancer in the adult kidney, and the prognosis of metastatic ccRCC remains poor with high mortality. In ccRCC, microRNAs (miRs) differentially expressed in tumour tissue have been identified and have been proposed to predict prognosis. The purpose of this study was to evaluate candidate miR markers identified from analysis of The Ca

Background: Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR). Methods: Twenty-se

The interaction between IgE and allergen is a key event at the initiation of an allergic response, and its characteristics have substantial effects on the clinical manifestation. Despite this, the molecular details of the interaction between human IgE and the major birch allergen Bet v 1, one of the most potent tree allergens, still remain poorly investigated.

A new species of Pegomya Robineau- Desvoidy, P. prisca sp. nov., is described from Europe ( Sweden, Czech Republic and Slovakia). It belongs to a species group together with the widespread West Palaearctic P. testacea ( De Geer) and P. hamata Wei described from China. Differential descriptions and illustrations of the terminalia are given for the two species of the Pegomya testacea species group f

The momentum distribution of electrons from decays of heavy flavor (charm and bottom) for midrapidity |y|< 0.35 in p+p collisions at s=200 GeV has been measured by the PHENIX experiment at the BNL Relativistic Heavy Ion Collider over the transverse momentum range 0.3 < p(T)< 9 GeV/c. Two independent methods have been used to determine the heavy-flavor yields, and the results are in good agreement

To estimate the prevalence and incidence of systemic sclerosis (SSc) in southern Sweden.

Objective To investigate whether an adjuvanted pandemic A/H1N1 2009 influenza vaccine in pregnancy was associated with an increased risk of fetal death. Design Nationwide register based cohort study. Setting Denmark. Participants All clinically recognised singleton pregnancies that ended between November 2009 and September 2010. Individual level data on exposure to an inactivated AS03 pandemic A/H

It has been shown that users of a digital system perceive a more ‘masculine-sounding’ female voice as more persuasive and intelligent than a corresponding but more ‘feminine-sounding’ female voice. Our study explores whether a parallel pattern of affectively colored evaluations can be elicited when femininity and masculinity are manipulated via visual cues instead of via voice. 80 participants enc

The development of tolerant microorganisms is needed for the efficient fermentation of inhibitory lignocellulose hydrolysates. In the current work, the fermentation performance of six selected strains of Saccharomyces cerevisiae in dilute-acid spruce hydrolysate was compared using two different modes of fermentation; either single pulse addition of hydrolysate to exponentially growing cells or con

For the past decade innovativeness, as opposed to innovation, has received considerable attention in the academic literature as well as the corporate arena because it is considered to promote a competitive advantage. This study examines the link between innovativeness and performance of SMEs in the Swiss watch industry, in terms of customer orientation, competition orientation and inter-functional

This study considered trends in the intergenerational transmission of social assistance (SA) among young adults in Finland, Norway and Sweden during the 2000s. Comparable administrative register data-sets enabled us to compare year by year the social assistance recipiency of 20-year-old adults in the period 1999–2008, together with information on their parents' social assistance recipiency at the

Abstract in Undetermined While women today often face a substantial wage penalty for childbearing, we show that this was not always the case, making use of a rich material of matched employer-employee data covering the Swedish tobacco industry in 1898 in its entirety. Although working conditions were dire, and hours long, women working in the late nineteenth-century manufacturing industry faced noWhile women today often face a substantial wage penalty for childbearing, we show that this was not always the case, making use of a rich material of matched employer-employee data covering the Swedish tobacco industry in 1898 in its entirety. Although working conditions were dire, and hours long, women working in the late nineteenth-century manufacturing industry faced no motherhood penalty. Comp

We present high spatial resolution ion-microprobe U-Th-Pb geochronology and rare earth element (REE) data combined with cathodoluminescence (CL) and back-scattered electron (BSE) imaging for complex zircons in incipient charnockites from Sondrum, SW Sweden. Examination of closely paired samples across the dehydration zone demonstrates that incipient charnockite formation at Sondrum is a zircon-for