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Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies

Objectives: Transfusion-related acute lung injury is characterized by the onset of respiratory distress and acute lung injury following blood transfusion, but its pathogenesis remains poorly understood. Generally, a two-hit model is presumed to underlie transfusion-related acute lung injury with the first hit being risk factors present in the transfused patient (such as inflammation), whereas the

The exterior Calderón operator for non-spherical objects

This paper deals with the exterior Calderón operator for not necessarily spherical domains. We present a new approach of finding the norm of the exterior Calderón operator for a wide class of surfaces. The basic tool in the treatment is the set of eigenfunctions and eigenvalues to the Laplace–Beltrami operator for the surface. The norm is obtained in view of an eigenvalue problem of a quadratic fo

Factor V Leiden paradox in a middle-aged Swedish population : A prospective study

Few prospective studies have examined the factor V paradox: factor V Leiden (FVL) is a stronger risk factor for deep venous thrombosis (DVT) than for pulmonary embolism (PE). The present study, to the best of our knowledge, is the first population-based study aimed to examine the relationship between FVL and incidence of venous thromboembolism (VTE), DVT and PE in a prospective cohort study of mid

Natural Resources Curse in the Long Run? Bolivia, Chile and Peru in the Nordic Countries’ Mirror

The new estimates of the Maddison Project show that GDP per capita ratio at purchasing power parity (ppp) between Bolivia and Finland has changed from 0.68 ca. 1850 to 0.16 in 2015; similarly, that between Chile and Norway from 0.65 to 0.28. The aim of this article is to present a review of the literature and available quantitative evidence to understand how these extreme differences became possib

Global Engagement and the Occupational Structure of Firms

Global engagement can impact firm organization and the occupations firms need. We use a simple task-based model of the firm's choice of occupational inputs to examine how that choice varies with global engagement. We reveal a robust and causal relationship between global engagement and the skill mix of occupations within firms, using Swedish matched employer-employee data that link firms and the l

‘Successful’ low-carbon energy transitions at the community level? An energy justice perspective

The aim of this paper is to critically analyse so-called ‘successful’ low-carbon energy transitions under the energy justice magnifying glass. We focus on two case studies that have been arguably referred to as successful local energy transitions in the literature: Samsø (Denmark) and Feldheim (Germany). The study examines community perspectives and causal inferences about perceived energy (in)jus

The role of Small Firms in the Technology Development of China

Science & Technology (S&T) is high on the Chinese policy agenda and the country aims at becoming an innovation-driven economy. Small firms have been important in technology development in other East Asian countries but the situation in Chinese small firms has been far less explored. We examine how much S&T has been accounted for by small firms and how their S&T intensity differs ac

The Shareholder Base Hypothesis of Stock Return Volatility : Empirical Evidence

We use Swedish ownership data to explore whether a large and diversified shareholder base leads to lower volatility by improving the information content of stock prices. We find that volatility increases in the number of shareholders with respect to both the number of relatively large shareholders and the fraction of shares held by investors with stakes below 0.1%. Volatility is also positively re

The network mediation of an incubator : How does it enable or constrain the development of incubator firms' business networks?

Incubators are organisations or structures that usually offer five types of services in order to accelerate start-up development: access to physical resources, administrative services, access to financial resources, assistance with start-up procedures and access to networks. The aim of the present paper is to investigate the mediating role of the incubator. More specifically, it examines how the i

Justice in the Prophetic Tradition

In my recent study Divining History: On Prophetism, Messianism and the Development of the Idea of the Spirit (Berghahn, 2016), I explored the notion of justice in the biblical-prophetic tradition. This paper is partly an extraction of the first and the last chapter of the book, but also goes further, as I try to delve deeper into the particular nature of this specific idea of justice. The paper co

The Evolving Future of Instantaneous Wave-Free Ratio and Fractional Flow Reserve

In this review, the authors reflect upon the role of coronary physiology in the modern management of coronary artery disease. They critically appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), from early experimental studies to validation studies against indexes of ischemia, to clinical trials assessing outcome. At this important junctu

Development of ACRODAT®, a new software medical device to assess disease activity in patients with acromegaly

Purpose: Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient’s perceived quality of life. We developed and validated a tool to measure disease activi

Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men

Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case–control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and li

Immunocompromised Patients. Infections, Diagnostics and Nosocomial Transmission

The aim of the work presented in this thesis was to improve the management ofinfections in immunocompromised patients by studying aspects of diagnostics,epidemiology and nosocomial transmission. Infection and rejection are commoncomplications in lung-transplant patients, and early diagnosis and treatment areimportant for a positive outcome. In a study of lung-transplant patients it wasfound that hThe aim of the work presented in this thesis was to improve the management of infections in immunocompromised patients by studying aspects of diagnostics, epidemiology and nosocomial transmission. Infection and rejection are common complications in lung-transplant patients, and early diagnosis and treatment are important for a positive outcome. In a study of lung-transplant patients it was found t