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The influence of dietary fibre source and gender on the postprandial glucose and lipid response in healthy subjects.
BACKGROUND: Consumption of soluble dietary fibre is correlated with decreased postprandial glucose and insulin responses and hence has beneficial effects on the metabolic syndrome. AIM OF THE STUDY: To investigate the effects on postprandial glucose, insulin and triglyceride concentrations of meals enriched with soluble dietary fibres from oats, rye bran, sugar beet fibre or a mixture of these thr
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A panel bootstrap cointegration test
This paper proposes a bootstrap test for the null hypothesis of cointegration in panel data. The test is general enough to allow for dependence both within and between the cross-sectional units, and is shown to work well in small samples.
Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes: a 4-year follow-up
Aim: To compare effects of early insulin vs. glibenclamide treatment on beta-cell function, metabolic control and quality of life (QL) in recently diagnosed patients with type 2 diabetes. Methods: Forty-nine patients with type 2 diabetes diagnosed 0-2 years before inclusion were randomized to two daily injections of premixed 30% soluble and 70% NPH insulin or glibenclamide at six diabetic clinics
Broad allelopathic activity in Peridinium aciculiferum (Dinophyceae)
The dinoflagellate Peridinium aciculiferum forms blooms underneath the ice in temperate lakes and has previously been shown to have an allelopathic effect on a natural competitor as well as being haemolytic. Hence, we investigated whether P. aciculiferum is allelopathic towards a wide range of different freshwater phytoplankton species. We also tested the hypothesis that nutrient (N and P) deficie
Quantitation of repetitive epitopes in glycosaminoglycans immobilized on hydrophobic membranes treated with cationic detergents
Glycosaminoglycans (GAGs) are linear carbohydrate polymers containing repetitive sequences of differently sulfated uronic acid and glycosamine residues that are recognized by antibodies raised against proteoglycans. We have developed a method to demonstrate such repetitive sequence motifs in isolated GAG chains immobilized on hydrophobic membranes derivatized with cationic detergents. Six monoclon
Vibration spectroscopy study of phenylphosphonate at the water-aluminum (hydr)oxide interface
Two previously published surface complexation models of phenylphosphonate on aged gamma-Al2O3 and boehmite (gamma-AlOOH), respectively, have been examined by means of FTIR and FT-Raman spectroscopy. The spectral features of adsorbed phenylphosphonate were studied as a function of pH and total phenylphosphonate concentration. No evidence for a phase transformation into a three-dimensional aluminum
Accurate QM/MM free energy calculations of enzyme reactions: Methylation by catechol O-methyltransferase
We recently described a method to compute accurate quantum mechanical free energies [Rod, T. H.; Ryde, U. Phys. Rev. Lett. 2005, 94, `138302]. The method, which we term quantum mechanical thermodynamic cycle perturbation (QTCP), employs a molecular mechanics force field to sample phase space and, subsequently, a thermodynamic cycle to estimate QM/MM free energy changes. Here, we discuss the method
Why do chest compressions aid delayed defibrillation?
The new resuscitation guidelines permit compressions before delayed, defibrillation, a change that has generally been welcomed. The benefits are generally assumed to relate to the immediate provision of limited coronary perfusion with protection or replenishment of myocardial metabolic reserves. In this paper we argue that the concept is inadequate to explain many experimental and clinical. observ
Glacial survival or late glacial colonization? Phylogeography of the root vole (Microtus oeconomus) in north-west Norway
Aim It has been proposed that the root vole subspecies, Microtus oeconomus finmarchicus, survived the last glacial period on islands on the north-west coast of Norway. The Norwegian island of Andoya may have constituted the only site with permanent ice-free conditions. Geological surveys and fossil finds from Andoya demonstrate that survival throughout the last glacial maximum was probably possibl
Plasma cytokines do not reflect expression of pro- and anti-inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs.
Background: Plasma concentrations of inflammatory markers are increased in response to the trauma of cardiac surgery and cardiopulmonary bypass (CPB). It is, however, unknown whether the plasma cytokine levels and cytokine mRNA expression at organ level reflect each other. Methods: Twenty-six piglets (17–19 days) were allocated to the sham-group (sternotomy only, n = 13) or to the CPB-group (ster
Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model.
AIMS/HYPOTHESIS: It has been suggested that the uterine environment may influence metabolic disease occurring later in adult life, and that adult stress may promote disease outcome. Using a mouse model, we tested whether in utero exposure to Ljungan virus (LV) followed by adult exposure to stress produces diabetes. The influence of the timing of viral exposure over the course of pregnancy was also
Use of a mandibular advancement device in patients with congestive heart failure and sleep apnoea.
Thawing permafrost and thicker active layers in sub-arctic Sweden
Observations of active-layer thickness from nine sites with up to 29 years of gridded measurements located in the Tornetrask region, northernmost Sweden, were examined in relation to climatic trends. Mean annual air temperatures in this area have warmed and recently rose above 0 degrees C. Active layers at all sites have become thicker, at rates ranging from 0.7 to 1.3 cm per year. This trend has
Silica filled poly(1-trimethylsilyl-1-propyne) and poly (4-methyl-2-pentyne) membranes: similarities and differences in structural characteristics and membrane performances
Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26.
Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia
Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ hybridization experiments show that DAPK mRNA expression is up-regulated in brain following a global ischemic insult and down-regulated in ischemic tissues after focal ischemia. DAPK is inactive in normal brain tissues, where it is found in its phosp
Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors
Deletions and structural rearrangements of the long arm of chromosome 13 are frequently observed in benign and low-malignant lipomatous tumors, but nothing is known about their molecular genetic consequences. We assessed the karyotypes of 40 new and 22 previously published cases (35 ordinary lipomas, 15 spindle cell/pleomorphic lipomas, 2 myxolipomas, 1 angiomyxolipoma and 9 atypical lipomatous tu
Effects of inoculation strategy and cultivation approach on the performance of microbial fuel cell using marine sediment as bio-matrix
Aims: To investigate the effects of inoculation strategy and cultivation approach on the performance of microbial fuel cell (MFC). Methods and Results: A dual-chamber sediment fuel cell was set up fed with glucose under batch condition. At day 30, the supernatant consortium was partly transferred and used as inoculum for the evaluation of cultivation approach. Power output gradually increased to 9