Search results

Filter

Filetype

Your search for "*" yielded 531757 hits

Distal landing zone outcomes in thoracic endovascular aortic aneurysm repair with challenging morphology : a propensity-matched comparison of distal active fixation versus standard stent-graft

BACKGROUND: To evaluate the distal landing zone (LZ) outcomes in adverse morphology after thoracic endovascular repair (TEVAR) with distal active fixation (DAF) stent-grafts compared with standard endografts.METHODS: between 2006 and the 31st December 2020, sixty-nine DAFs (study group) and sixty-nine standard stent-grafts (control group) were enrolled in a multi-center, retrospective, case-contro

Population heterogeneity in associations between hormonal contraception and antidepressant use in Sweden : a prospective cohort study applying intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA)

OBJECTIVES: From a reproductive justice framework, we aimed to investigate how a possible association between hormonal contraceptive (HC) and antidepressants use (as a proxy for depression) is distributed across intersectional strata in the population. We aimed to visualise how intersecting power dynamics may operate in combination with HC use to increase or decrease subsequent use of antidepressa

Why should we distinguish between the exercise of discretion and interpretation?

The exercise of discretion is a central feature of international legal decision-making. ‘Discretion’, in a loose sense, refers to a power vested in an agent as part of an assignment to make legal decisions. It enables the agent to perform its (or his/her) assignment, while giving it at the same time the possibility to choose between diverse courses of action. This not to say that this agent has thThe exercise of discretion is a central feature of international legal decision-making. ‘Discretion’, in a loose sense, refers to a power vested in an agent as part of an assignment to make legal decisions. It enables the agent to perform its (or his/her) assignment, while giving it at the same time the possibility to choose between diverse courses of action. This not to say that this agent has th

Genetically targeted clinical trials in parkinson’s disease : Learning from the successes made in oncology

Clinical trials in neurodegenerative disorders have been associated with high rate of failures, while in oncology, the implementation of precision medicine and focus on genetically defined subtypes of disease and targets for drug development have seen an unprecedented success. With more than 20 genes associated with Parkinson’s disease (PD), most of which are highly penetrant and often cause early

The Drivers of Medium-Scale Farms and the Emerging Synergies and Contradictions Among Socially-Differentiated Farmers in Northern Ghana

Since the turn of the century, agriculture in sub-Saharan Africa has been undergoing rapid transformation. Ghana is experiencing an agrarian revolution with increasing farmland sizes, increased mechanisation of production and external input usage, and high levels of commercialisation. In this paper we show the growth of farm sizes, the major drivers of increasing farm sizes, and emerging relations

Longitudinal Mycobacterium tuberculosis-specific Interferon Gamma responses in Ethiopian HIV-negative women during pregnancy and postpartum

Pregnancy may influence cellular immune responses to Mycobacterium tuberculosis. We investigated M. tuberculosis-specific interferon-g responses in women followed longitudinally during pregnancy and postpartum. Interferon-g levels (stimulated by M. tuberculosis antigens [TB1 and TB2] and mitogen included in the QuantiFERON-TB Gold Plus assay) were measured in blood from pregnant HIV-negative women

The inner flow geometry in MAXI J1820+070 during hard and hard-intermediate states

Context. We present a systematic X-ray spectral-timing study of the recently discovered, exceptionally bright black hole X-ray binary system MAXI J1820+070. Our analysis focuses on the first part of the 2018 outburst, covering the rise throughout the hard state, the bright hard and hard-intermediate states, and the transition to the soft-intermediate state. Aims. We address the issue of constraini

FPGA Implementation of In-Cycle Closed-Loop Combustion Control Methods

This paper investigates the FPGA resources for the implementation of in-cycle closed-loop combustion control algorithms. Closed-loop combustion control obtains feedback from fast in-cylinder pressure measurements for accurate and reliable information about the combustion progress, synchronized with the flywheel encoder. In-cycle combustion control requires accurate and fast computations for their

Long-term consequences of bilateral cavernous crush injury in normal and diabetic rats : a functional study

A recent statement from the European-Society-for-Sexual-Medicine has highlighted the limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with no comorbidities and the early evaluation of the erectile function (EF) are deemed a source of bias. Our aim was to evaluate the long-term consequences in EF of bilateral nerve cavernous crush- injury (BNCI) in type 1 di

Aquaporins in pancreatic ductal adenocarcinoma

Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over- or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes involved in cancer development and progressio

Case Report: "Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy"

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary EC

A holin/peptidoglycan hydrolase-dependent protein secretion system

Gram-negative bacteria have evolved numerous pathways to secrete proteins across their complex cell envelopes. Here, we describe a protein secretion system that uses a holin membrane protein in tandem with a cell wall-editing enzyme to mediate the secretion of substrate proteins from the periplasm to the cell exterior. The identity of the cell wall-editing enzymes involved was found to vary across

Surf and turf : A dataset of stable isotope values of plants and animals from southern California

This article presents baseline isotope values for plant and animal samples collected from across southern California. A total of 80 samples representing 50 species were collected and analyzed for this project. This original dataset includes 31 plant species, 13 finfish species, 3 mollusk species, 2 crustacean species, and 1 echinoderm. Plant samples were collected by the authors and an undergradua

Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver

Purpose: Intravoxel incoherent motion (IVIM) studies are performed with different acquisition protocols. Comparing them requires knowledge of echo time (TE) dependencies. The TE-dependence of the biexponential perfusion fraction f is well-documented, unlike that of its triexponential counterparts f1 and f2 and the biexponential and triexponential pseudodiffusion coefficients D*, (Formula presented

Vibrotactile sense in children with type 1 diabetes

Poster A153Introduction: Diabetic peripheral neuropathy (DPN) is a devastating complication to DM, potentially leading to diabetic foot ulcers. Studies using electrophysiology shows high occurrence of subclinical DPN among children, but it is unclear when and how to start screen children with T1D for DPN. Aim: To investigate whether evaluation of the vibrotactile sense, using a multi-frequency method, in the