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Deep eutectic solvents for the preservation of concentrated proteins : the case of lysozyme in 1 : 2 choline chloride : glycerol

The stability and activity of a model protein, lysozyme, in 1 : 2 choline chloride : glycerol was characterised across a wide range of protein concentrations, i.e., between 4 and 143 mg ml−1, where the protein is soluble and physically stable. Lysozyme folds into a globular conformation in this deep eutectic solvent like that in the native state, but with subtle variations in its internal structur

Cell-Free Massive MIMO: Exploiting The Wax Decomposition

Cell-free massive multiple-input multiple-output (MIMO) consists of a large set of distributed access points (APs) serving a number of users. The APs can be far from each other, and they can also have a big number of antennas. Thus, decentralized architectures have to be considered so as to reduce the interconnection bandwidth to a central processing unit (CPU) and make the system scalable. On the

Boundary-Monte Carlo Method for Neutral and Charged Confined Fluids

In this work, we describe a new Monte Carlo (MC) simulation method to investigate highly coupled fluids in confined geometries at a constant chemical potential. This method is based on so-called multi-scale Hamiltonian methods, wherein the chemical potential is determined using a more amenable Hamiltonian for a fluid in an "outer"region, which facilitates standard methods, such as grand canonical

Planning Urban Futures for Autonomous and Shared Vehicles : The Role of Planning Support Tools as a Policy Instrument

Modelling has been a mainstay of conventional planning support tools (PSTs) since the 1960s and is instrumental in transport and land use planning decision-making. Numerous studies have been conducted to model the potential impacts of emerging vehicle automation and sharing technologies. A systematic review of recent modelling studies of autonomous and shared vehicles in the research literature ex

Assessment of Distributed Acoustic Sensing (DAS) performance for geotechnical applications

Distributed Acoustic Sensing (DAS) is a recent technology that acquires acoustic vibrations via fiber optics sensors. The utilization of such technique for near-surface geotechnical applications has great potential, especially for the characterization and verification of artificially stabilized ground. A popular procedure to stabilize the superficial ground (for example, for the preparation of inf

A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography

Musculoskeletal tissues are complex hierarchical materials where mechanical response is linked to structural and material properties at different dimensional levels. Therefore, high-resolution three-dimensional tomography is very useful for assessing tissue properties at different scales. In particular, Synchrotron Radiation micro-Computed Tomography (SR-microCT) has been used in several applicati

Politiker måste våga minska privatbilismen : Forskare: Fler grönytor behövs mot extremväder

För att att minska städernas koldioxidutsläpp relaterat till val av byggmaterial, byggprocess samt energianvändningen i våra boenden skulle fler hus behöva byggas i trä, renovering i högre grad väljas i stället för rivning, husen skulle behöva göras mer energieffektiva och vi skulle behöva bo fler på mindre yta, menar Johanna Alkan Olsson, docent i miljövetenskap vid Lunds universitet och speciali

Self-rated health in Swedish pregnant women : a comprehensive population register study

Background/Aims Sociodemographic factors are associated with perceived overall health status or ‘self-rated health’. However, research using data from the comprehensive population register in Sweden to examine self-rated health in pregnant women is limited. This study aimed to examine sociodemographic factors associated with self-rated health before, during and after pregnancy in low-risk pregnant

The HIV-1 epidemic in Ethiopia – transmission patterns, antiretroviral drug resistance and treatment outcomes

A comprehensive understanding of local HIV epidemiology is essential for monitoring transmission, designing, implementing, and evaluating HIV intervention strategies. In paper I, we used a total of 1276 HIV-1 subtype C pol sequences and employed state-of-art phylogenetic and phylodynamic tools to describe the molecular epidemiology of HIV in Ethiopia. Our results showed that the HIV epidemic in Et

The Risk of Endometrial Malignancy and Other Endometrial Pathology in Women with Abnormal Uterine Bleeding : An Ultrasound-Based Model Development Study by the IETA Group

Objectives: The aim of this study was to develop a model that can discriminate between different etiologies of abnormal uterine bleeding. Design: The International Endometrial Tumor Analysis 1 study is a multicenter observational diagnostic study in 18 bleeding clinics in 9 countries. Consecutive women with abnormal vaginal bleeding presenting for ultrasound examination (n = 2,417) were recruited.

Analysis of Changes in the Beat-to-Beat P-Wave Morphology Using Clustering Techniques

Several pathologies related to the atrial electrical activity can be detected in the electrocardiogram P-wave. A study on the beat-to-beat P-wave morphology changes of 89 ECG signals is performed in this article. An algorithm based on the embedding space techniques has been used to extract the P-wave information of the ECG. The P-waves obtained in several of these ECGs exhibit intermittent morphol

Association between central haemodynamics and renal function in advanced heart failure : a nationwide study from Sweden

Aims: Renal dysfunction in patients with heart failure (HF) has traditionally been attributed to declining cardiac output and renal hypoperfusion. However, other central haemodynamic aberrations may contribute to impaired kidney function. This study assessed the relationship between invasive central haemodynamic measurements from right-heart catheterizations and measured glomerular filtration rate

Contrasting characteristics, changes, and linkages of permafrost between the Arctic and the Third Pole

Permafrost degradation poses serious threats to both natural and human systems through its influence on ecological–hydrological processes, infrastructure stability, and the climate system. The Arctic and the Third Pole (Tibetan Plateau, TP hereafter) are the two northern regions on Earth with the most extensive permafrost areas. However, there is a lack of systematic comparisons of permafrost char

Unilateral or Bilateral Retroperitoneal Lymph Node Dissection in Nonseminoma Patients with Postchemotherapy Residual Tumour? Results from RETROP, a Population-based Mapping Study by the Swedish Norwegian Testicular Cancer Group

BACKGROUND: The distribution of retroperitoneal lymph node metastases for patients with nonseminoma and a residual tumour of 10-49 mm in a population-based setting is unknown. This information is needed to justify selection of patients for a unilateral template resection. OBJECTIVE: To describe the location of retroperitoneal metastases and recurrences in patients with nonseminoma germ cell tumour

The PEPSI exoplanet transit survey (PETS) I : Investigating the presence of a silicate atmosphere on the super-earth 55 Cnc e

The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most

Transgressing purity: Intersectional negotiations of gender identity in Swedish schools

The vulnerability of gender nonconforming young people is all too well documented. Arguably, “trans issues” in schools are not restricted to transphobic comments, and need to be analyzed intersectionally. Guided by Lugones’ discussion of the politics of purity read together with the analysis of cisnormativity, this article draws on interviews with Rakel, Robin and Mika, who were part of a larger s

Idén om en ”det enda syftets” kärnvapendoktrin : Konsekvenser för USA:s allierade, för Nato och den nukleära delaktigheten

USA:s president Joseph R Biden överväger att ändra USA:s politik för kärnvapenavskräckning. Sedan kärnvapenålderns början har Washington alltid förklarat att man kan komma att svara med kärnvapen som vedergällning, inte bara på attacker med kärnvapen, utan även på icke-nukleära aggressioner. Denna deklaratoriska politik kan snart komma att skärpas: Biden skulle vilja minska kärnvapnens roll genom U.S. President Joseph R. Biden is considering changing the United States’ policy on nuclear deterrence. Since the beginning of the nuclear age, Washington has always declared that it could respond with nuclear retaliation not only to attacks with nuclear weapons, but also to non-nuclear aggression. That declaratory policy may soon be tightened: Biden would like to reduce the role of nuclear weapon