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Ambulance clinicians’ attitudes to older patients’ self-determination when the patient has impaired decision-making ability: A Delphi study

ObjectiveThe proportion of older people is increasing and reflects in the demand on ambulance services (AS). Patients can be more vulnerable and increasingly dependent, especially when their decision-making ability is impaired. Self-determination in older people has a positive relation to quality of life and can raise ethical conflicts in AS. Hence, the aim of this study was to empirically explore

Electoral infidelity : Why party members cast defecting votes

Party politics and electoral research generally assume that party members are loyal voters. This article first assesses the empirical basis for this assumption before providing individual-level explanations for defection. It combines prominent theories from party politics and electoral behaviour research and argues that internal disagreement and external pressure can each bring about disloyal voti

Developing shared languages : The fundamentals of mutual learning and problem solving in transdisciplinary collaboration

This issue of the AILA Review focuses on transdisciplinarity as the key to developing shared languages in and across domains and professional settings. The relationship and collaboration between researchers and practitioners have long been discussed within and across applied sciences and theoretical disciplines, mainly in the framework of transdisciplinarity (see AILA Review 31, 2018, for a recent

Assessing the potential and hydrological usefulness of the CHIRPS precipitation dataset over a complex topography in Pakistan

This study evaluates the spatial and temporal performance of the Climate Hazard Group InfraRed Precipitation Satellite (CHIRPS) against Tropical Rainfall Measuring Mission (TRMM) Multi-Satellite Precipitation Analysis (TMPA) 3B42/3B43 v. 7 and Global Precipitation Measurement (GPM)-based Integrated Multi-Satellite Retrievals for GPM (IMERG V06), from 2000 to 2013. Several statistical metrics were

Maskinkroppens gräns : Våld, immunitet och medieakologiska aggregationer i The Last of Us

This article examines the portrayal of bodily boundaries in the videogame series The Last of Us. Drawing on theories of media ecology and posthumanism (most notably Deer’s notion of radical animism, Haraway’s theories of the cyborg, and Fuller’s account of media assemblages), three aspects of this portrayal are described: first, the game’s narrativization of bodily violence through an amalgamation

Energy dependence of ϕ meson production at forward rapidity in pp collisions at the LHC

The production of ϕ mesons has been studied in pp collisions at LHC energies with the ALICE detector via the dimuon decay channel in the rapidity region 2.5 < y< 4. Measurements of the differential cross section d 2σ/ d yd pT are presented as a function of the transverse momentum (pT) at the center-of-mass energies s=5.02, 8 and 13 TeV and compared with the ALICE results at midrapidity. The differ

Development of a fast-virtual CFR engine model and its use on autoignition studies

Homogenous charge compression ignition engines have been studied as an alternative to the conventional diesel combustion to attain high efficiency with ultra-low NOx and soot emissions for a wide variety of fuels. However, its usage in real applications has been restricted due to the difficulties regarding combustion control and operating range extension. The modification of the fuel characteristi

Att tala till kvinnor och vinna deras röster : Socialdemokratiska kvinnoförbundets agitation inför valet 1921

I denna uppsats studeras socialdemokratiska kvinnors organisering och kampanjmetoder vid tiden för den allmänna och lika rösträttens införande. Undersökningen visar att erfarna kvinnliga agitatorer var mycket efterfrågade och ger exempel på kvinnoförbundets strategier för att trots begränsade resurser ordna talarturnéer. I den skriftliga agitationen tilltalades kvinnliga väljare både som del av et

Intramolecular interactions dominate the autoregulation of escherichia coli stringent factor RelA

Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp. The alarmone acts as an intercellular messenger to regulate transcription, translation and metabolism to mediate bacterial stress adaptation. The enzymatic activity of RelA is subject to multi-layered allosteric control executed both

An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea

Background: SelB is the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome. In archaea, only a subset of methanogens utilizes selenocysteine and encodes archaeal SelB (aSelB). A SelB-like (aSelBL) homolog has previously been identified in an archaeon that does not encode selenosysteine, and has been proposed to be a pyrrolysyl-tRNA-specific elongation factor (EF-Pyl).

Two-Step Selection of mRNAs in Initiation of Protein Synthesis

In a recent issue of Molecular Cell, Studer and Joseph (2006) clarified the molecular basis of the "standby model" and demonstrated how two-step binding of mRNAs to the small ribosomal subunit depends on initiator tRNA and initiation factors, with far-reaching implications for posttranscriptional regulation of gene expression.

Violating the thermodynamic uncertainty relation in the three-level maser

Nanoscale heat engines are subject to large fluctuations which affect their precision. The thermodynamic uncertainty relation (TUR) provides a trade-off between output power, fluctuations, and entropic cost. This trade-off may be overcome by systems exhibiting quantum coherence. This Letter provides a study of the TUR in a prototypical quantum heat engine, the Scovil–Schulz-DuBois maser. Compariso

Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

The pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle by converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active subunits, namely pyruvate dehydrogenase, dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase. Dihydrolipoyl transacetylase is a multidomain protein comprising a varying number of lipoyl domains, a peripheral subunit

Cortical Activity During an Attack of Ménière's Disease-A Case Report

Background: Ménière's disease (MD) is a chronic peripheral vestibular disorder with recurrent episodes of vertigo accompanied by fluctuating hearing loss, tinnitus and aural fullness in the affected ear. There are several unanswered fundamental questions regarding MD, one of these being cortical activity during a MD attack. However, it is not possible to plan an investigation in an episodic diseas