Sökresultat

At the heart of protein's aggregation are specific molecular events; and how they are modulated by changes in solvent conditions and temperature is key to our understanding and control of aggregation. A certain class of structural fibrous proteins may provide the answer. Indeed, spider silk and silkworm silk proteins have evolved to readily form ‘insoluble’ ordered structures. But, to date little

This article aims to offer an overview of the rise, growth and diversification of academic music research in Sweden. ‘Research in music’ is suggested as a comprehensive term, covering all kinds of research relating to music.In 1915 the Swedish University Chancellor’s office established a syllabus for ‘music history and theory’ at Lund University. The syllabus was initiated by Tobias Norlind, and i

BACKGROUND: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associ

5G promises to usher in the industrial 4.0 era. In that era, intricately managed autonomous industrial sites with for example remotely controller equipment and autonomous units promise previously unseen levels of efficiency. Although such scenarios are elusive, they come with strict long-since established safety requirements. To uphold such requirements, intelligent industrial 5G networks, that ac

Currently there is an ongoing push towards a circular economy. Governments, the EU, green NGOs, think-tanks, companies and their industry organizations are all advocating more circular solutions meaning that the current linear take-make-use-lose model of consumption should be replaced with a reuse-repair-recycle circular model. The circular economy is being heralded as one of the main, if not the

Background: Polychlorinated biphenyls (PCBs) were used in electrical equipment and a range of construction materials. Although banned in the United States and most of Europe in the 1970s, they are highly persistent in the environment and bioaccumulate. Whether PCBs are associated with liver cancer risk at general population levels is unknown. Methods: This study consisted of 136 incident liver can

Recension av Magnus Linton, Text & Stil. Om konsten att berätta med vetenskap. Bedömningen är avgjort positiv. Linton har skrivit en träffande, relevant, adekvat bok för alla som skriver sakprosa – samhälls- och kulturvetare, humanister, essäister. Boken är full av exempel och mindre full av goda råd. Den är därtill mycket välskriven och välkomponerad.

Here we aimed to unify some previous controversial reports on changes in both cannabinoid CB1 receptor (CB1R) expression and glucose metabolism in the forebrain of rodent models of diabetes. We determined how glucose metabolism and its modulation by CB1R ligands evolve in the frontal cortex of young adult male Wistar rats, in the first 8 weeks of streptozotocin-induced type-1 diabetes (T1D). We re

This experience article describes lessons learned as we conducted experiments in a Kubernetes‐based environment, the most notable of which was that the performance of both the Kubernetes control plane and the deployed application depends strongly and in unexpected ways on the performance of the etcd database. The article contains (a) detailed descriptions of how networking with and without Istio w

Service meshes factor out code dealing with inter-micro-service communication. The overall resilience of a cloud application is improved if constituent micro-services return stale data, instead of no data at all. This paper proposes and implements application agnostic caching for micro services. While caching is widely employed for serving web service traffic, its usage in inter-micro-service comm

In the Industry 4.0 era, time-sensitive and missioncritical control applications still have a long way to go, from being tied down and co-located with the systems they control, to taking full advantage of the cloud. Conservatively keeping applications local will deprive these complex applications of abundantcompute capacity, wider system integration, and the potential for collaborative control eff

We examine the relationship between occupational automation probabilities and employment dynamics over nearly two decades. We show that employment and wage shares of occupations with a higher automation risk have declined in Sweden over the period 1996-2013. This has occurred both at the aggregate private business sector but also within firms, where the wage share changes have been larger than the

AIMS/HYPOTHESIS: Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity

AIM: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Nagao Diabetes-Prone [ON-DP] and -Resistant [ON-DR]) to evaluate the effect of metf

Immune checkpoint inhibitor therapies targeting PD‐1/PD‐L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD‐L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab‐paclitaxel. How