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Polarity and growth directions in Sn-seeded GaSb nanowires

We here investigate the growth mechanism of Sn-seeded GaSb nanowires and demonstrate how the seed particle and its dynamics at the growth interface of the nanowire determine the polarity, as well as the formation of structural defects. We use aberration-corrected scanning transmission electron microscopy imaging methodologies to study the interrelationship between the structural properties, i.e. p

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

Ageing associates with significant alterations in somatic/adult stem cells and therapies to counteract these might have profound benefits for health. In the blood, haematopoietic stem cell (HSC) ageing is linked to several functional shortcomings. However, besides the recent realization that individual HSCs might be preset differentially already from young age, HSCs might also age asynchronously.

Minimally important change, measurement error, and responsiveness for the Self-Reported Foot and Ankle Score

Background and purpose — Patient-reported outcome measures (PROMs) are increasingly used to evaluate results in orthopedic surgery. To enhance good responsiveness with a PROM, the minimally important change (MIC) should be established. MIC reflects the smallest measured change in score that is perceived as being relevant by the patients. We assessed MIC for the Self-reported Foot and Ankle Score (

Persistent changes in striatal gene expression induced by long-term L-DOPA treatment in a rat model of Parkinson's disease

Current knowledge of the molecular changes induced by dopamine denervation and subsequent treatment with L-DOPA is based on studies performed on relatively acute and young animal models of parkinsonism. It is highly warranted to ask how well these models simulate the state of chronic denervation and sustained L-DOPA pharmacotherapy which are typical of advanced Parkinson's disease. This study inve

Degradation and fatigue of epoxy impregnated traction motors due to thermal and thermal induced mechanical stress - Part II : Thermal mechanical simulation of multiple wires due to evenly and unevenly distributed temperature

Part I of the study presents the importance and the analytical and numerical methods to perform a thermal- mechanical stress simulation with evenly distributed temperature for single wires. Part II of the study presents a method with thermal and mechanical conjugated simulations with unevenly distributed temperature for multiple wires and the results are compared to the structural simulation with

Does sugar inhibition explain mixing effects in enzymatic hydrolysis of lignocellulose?

BACKGROUND: Enzymatic hydrolysis of lignocellulose is associated with mixing issues, which are likely to affect process performance. The aim of this study was to investigate how viscosity and sugar inhibition influence the mixing-dependence in hydrolysis of steam-pretreated spruce. RESULTS: The effect of agitation on low-viscosity, low-solid hydrolysis (5% water insoluble solid (WIS)) was marginal

Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle

31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusi

Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets

A new model-free method is presented that automatically corrects for phase shifts, frequency shifts, and additional lineshape distortions of one single resonance peak across a series of in vivo NMR spectra. All separate phase and frequency variations are quickly and directly derived from the common lineshape in the data set using principal component analysis and linear regression. First, the new a

The pig as a model for premature infants - The importance of immunoglobulin supplementation for growth and development

Preterm human neonates, contrary to preterm piglets, obtain immunoglobulins from their mothers via the placenta during intrauterine development. However, one should note that the majority of trans-placental transfer of immunoglobulins in humans takes place during the last trimester of pregnancy. It is also known that the feeding of limited amounts of colostrum or systemic infusion of small amounts

Narrow-band diffuse ultrasonic wavefield measurements in a network of reciprocal transducers for monitoring of a large concrete floor slab

Piezoelectric transducers were attached in a grid on the surface of an 8 x 2 x 0.08 m concrete floor slab. Through an automated, iterative scheme these were used to transmit and receive 50 kHz, continuous, sinusoidal signals, which were sampled by a multi-channel lock-in amplifier. The measured amplitude and phase were used to locate inflicted damage by detecting deviations from baseline measureme

Validation of new superheavy elements and IUPAC-IUPAP joint working group

The great chemist Glenn Seaborg has written a delightful little book "Man-made Transuranium Elements", published in 1963, in which he points out that: "The former basic criterion for the discovery of a new element - namely, chemical identification and separation from all previously-known elements - had to be changed in the case of lawrencium (element 103). This also may be true for elements beyond

Thomas Piketty and the rate of time preference

Using a standard model in which the individual consumption path is computed solving an optimal control problem, we investigate central claims of Piketty (2014). Rather than r > g (confirmed in the data) r−ρ>g – with ρ being the rate of time preference – matters. If this condition holds and the elasticity of substitution in the production function is larger than one, the capital share converges to

On cash settled IRR-swaptions and Markov functional modeling

In this paper, we show how to consistently price cash settled Internal Rate of Return (IRR)-swaptions and derivatives on these contracts. There are several results worth highlighting. First, if we know at what fixed coupon an IRR-swap values to par, we can compute the price of any IRR-swaption in a way consistent with absence of arbitrage. We show that this fixed coupon, denoted the IRR-forward, c

Police officer involved shootings – retrospective study of situational characteristics

The study analyzed the situational characteristics of 112 incidents where police used firearms to handle high threat situations. Most shooting incidents emanated from usually uneventful tasks, e.g., handling burglaries or disturbances. The assailants were commonly armed with firearms (26%), sharp (27%) or blunt objects (10%). The incidents were regularly short-lasting (in 39% were shots fired ≤3 s

Health status and lung function in the Swedish alpha 1-antitrypsin deficient cohort, identified by neonatal screening, at the age of 37-40 years

Background: Severe alpha 1-antitrypsin (AAT) deficiency (genotype PiZZ) is a well-known risk factor for COPD. A cohort of PiZZ and PiSZ individuals was identified by the Swedish national neonatal AAT screening program in 1972-1974 and followed up regularly since birth. Our aim was to study the lung function, respiratory symptoms and health status at the age of 38 years in comparison with a random