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We studied mutation kinetics in ten relapsing and four non-relapsing patients with acute myeloid leukemia by whole exome sequencing at diagnosis to identify leukemia-specific mutations and monitored selected mutations at multiple time-points using IBSAFE droplet digital PCR. Five to nine selected mutations could identify and track leukemic clones prior to clinical relapse in 10/10 patients at the

Entrepreneurial Ecosystems (EEs) are expected to support high growth entrepreneurship. Yet, little is known about how they actually promote entrepreneurial activities. Based on Giddens’ structuration theory, this paper takes the entrepreneurs’ perspective to understand how they actually use the resources provided by an EE. Based on semi-structured interviews with entrepreneurs and other relevant a

The main aims with this book are to compare source materials, databases and research results, as well as creating new opportunities for collaboration in the field of social and population history in the East and the West. All the contributions are based on nominative source material, mainly censuses and vital records, which have been preserved, scanned, transcribed into databases in order to be us

This thesis includes a compilation of four publications with a long-term perspective on the mechanisms of social reproduction and the general trends of socioeconomic inequality in the Barcelona area between the fifteenth and the nineteenth centuries. The familial mechanisms of social reproduction encompass economic, institutional, legal, political, and/or cultural mechanisms for maintaining, impro

Resum:The role of the family in both individual social status attainment and labor careers during industrialization was questioned by the Modernization theory. Accordingly, familial nuclearization was argued to be one of the causes. However, little has been said on this topic regarding societies in which stem or joint families were important as in the case of Southern Europe. This article studies

The paper starts from the hypothesis that materialist state theories (particularly Gramsci, Bourdieu and Poulantzas) and sustainable welfare approaches are capable of informing state-led ‘eco-social’ policy strategies that have the potential of overcoming the growth imperative in economy and society. It first outlines some general principles of such state action concerning economy, welfare, enviro

BackgroundRight ventricular (RV) function is a major determinant of outcome in patients with pulmonary hypertension. Cardiac magnetic resonance (CMR) is gold standard to assess RV ejection fraction (RVEFCMR), however this is a crude measure. New CMR measures of RV function beyond RVEFCMR have emerged, such as RV lateral atrio-ventricular plane displacement (AVPDlat), maximum emptying velocity (S’C

The global transition to a low-carbon economy will involve changes in material markets and supply chains on a hitherto unknown scale and scope. With these changes come numerous challenges and opportunities related to supply chain security and sustainability. To help support decision-making as well as future research, this study employs a problem-oriented perspective while reviewing academic public

Swedish emergency services still have relatively limited resources and time for proactive fire prevention. Because of this, there is an extensive need for strategic working methods and knowledge to take advantage of spatial analyses. In addition, decision-making based on visualizations and analyses of their own collected data has the potential to increase the validity of strategic decisions. The o

Purpose: Pulmonary involvement is common in adults with scleroderma. The effect of concomitant obstructive sleep apnea (OSA) on risk for pulmonary hypertension in scleroderma is unknown. An enlarged main pulmonary artery diameter (mPAD) derived from chest computer tomography (CT) is a useful predictor of pulmonary hypertension. We addressed the effect of OSA on pulmonary involvement and enlarged m

Purpose: The present study aimed to assess the risk of obstetric anal sphincter injuries (OASIS) of a subsequent delivery after the previous OASIS in countries with low (Finland) and high rates (Norway and Sweden) of OASIS. Methods: This population-based case–control study included women who experienced OASIS 1997–2002. 26,598 women with OASIS were included from countries with low (Finland) and hi

Chronic mesenteric ischaemia is a severe and incapacitating disease, causing complaints of post-prandial pain, fear of eating and weight loss. Even though chronic mesenteric ischaemia may progress to acute mesenteric ischaemia, chronic mesenteric ischaemia remains an underappreciated and undertreated disease entity. Probable explanations are the lack of knowledge and awareness among physicians and