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Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Unlike glucose, the sub-optimal xylose utilization in recombinant Saccharomyces cerevisiae strains may stem from an unusual signaling response that is not adapted to detecting xylose as a fermentable substrate. We hypothesize that the membrane receptor Snf3p, known for sensing extracellular low glucose levels, may contribute to xylose recognition. To test this, we explored the effect of SNF3 inact
Using terahertz and transient absorption spectroscopy, carrier dynamics in organo halide perovskite solar cell is probed. Charge generation is <100 fs, followed by 2 ps charge formation with balanced electron hole mobility of 20 cm2V-1s-1.
Movement disorders are common in inherited metabolic diseases (IMDs) and significantly impact quality of life. Unfortunately, they are often underrecognised by metabolic physicians. This study investigated whether a new screening tool improves recognition of movement disorders in IMD patients by non-neurologists. Internists and paediatricians specialized in IMDs assessed videos of 44 IMD patients
The thesis is devoted to sharp embeddings from Soblolev spaces into Lebesque spaces in one dimension. The paper included in the thesis concerns the embedding from Sobolev spaces of functions that have square integrable derivatives of integer order k into the space of Lebesgue integrable functions (p=1). The main result is the sharp constant and the explicit extremal functions given by the Landau k
In the era of artificial intelligence of things (AIoT), distributed processing on local devices is growing in popularity. This stems from the need to reduce data transfer to and from central servers, with concerns about privacy and latency encouraging the processing of AI applications on edge devices. However, the computational demands of these applications require an increase in the processing ca
We obtain sharp embeddings from the Sobolev space (Formula presented.) into the space (Formula presented.) and determine the extremal functions. This improves on a previous estimate of the sharp constants of these embeddings due to Kalyabin.
The recognized importance of systemic and dynamic perspectives on both AI and innovation management calls for the retheorization to support the AI technology adoption in innovation management. As extant knowledge about a systems approach to realize dynamic roles of both augmentation and automation of AI-human collaboration in innovation management is limited, this study aims to explore how to leve
This chapter explores the evolution and effectiveness of Sweden's climate policy mix for decarbonizing the transport sector—a major contributor to national greenhouse gas (GHG) emissions. Despite early leadership in climate policy, Sweden faces challenges in aligning policy implementation with ambitious goals, such as a 70 % reduction in transport emissions by 2030. The chapter shows that Sweden's
The purpose of the present paper is to describe and discuss the concept of hunter mode, as introduced by Meidell (2022) in her autobiographical description of anorexia nervosa. Hunter mode is a sought-after state that is reached through self-starvation and that transforms a person’s experiences into a crystal-clearperception and a sense of vitality. Although partly touched upon already by Hilde BrThe purpose of the present paper is to describe and discuss the concept of hunter mode, as introduced by Meidell (2022) in her autobiographical description of anorexia nervosa. Hunter mode is a sought-after state that is reached through self-starvation and that transforms a person's experiences into a crystal-clear perception and a sense of vitality. Although partly touched upon already by Hilde B
Social services are adapting to an increasingly digital environment, with municipalities expectedto engage citizens through digital channels. This study investigates how clients seeking social as-sistance perceive and use digital tools as well as the challenges and opportunities that arise whenimplementing such technologies in line with public service values. The analysis draws on municipaldigitalSocial services are adapting to an increasingly digital environment, with municipalities expected to engage citizens through digital channels. This study investigates how clients seeking social assistance perceive and use digital tools as well as the challenges and opportunities that arise when implementing such technologies in line with public service values. The analysis draws on municipal digit
Many species are currently experiencing range shifts in response to changing environmental conditions with potentially serious genetic consequences. Repeated founder events and strong genetic drift are expected to erode genetic variation at the range front, reducing adaptive potential and slowing or even halting the expansion. However, the severity of these consequences for common and highly mobil
Expands the scope of Islamic Studies to include the study of non-Muslim Islam Introduces a new concept (non-Muslim Islam) that challenges commonly held notions about the object of study within Islamic studies Invites critical thinking about how knowledge about Islam is produced in non-Muslim majority societies on both a scholarly and societal level This book empirically substantiates a re-conceptu
The multiexciton density matrix theory is utilized to achieve a microscopic description of exciton-exciton annihilation (EEA). We apply the theory to the 18 bacteriochlorophyll (BChl) molecules of the B850 ring of the light-harvesting complex LH2 of Rhodobacter sphaeroides. The simulation of the EEA process reproduces the intensity-dependent transient absorption kinetic experiments very well, and
This study presents a transformative advancement in water-energy nexus management by developing a hydrostatic pressure wheel (HPW) system that simultaneously optimizes water level regulation and hydropower generation in open-channel irrigation systems (OCISs)—a dual functionality not achieved by existing technologies. While conventional waterwheels focus solely on energy production, our HPW design
Tunnel evacuation is a challenge that requires a well-prepared strategy and relevant technical andorganizational measures to be successful. The article focuses on the relation between knowledge abouthuman behaviour during an evacuation process and how this knowledge is obtained throughinvestigations after fires and through well-planned experiments. Furthermore, theories are introducedthat explain
A risk indexing method for evaluating safety in railway tunnels has been developed. Firstly, ahierarchical structure with one objective, three sub-objectives, four strategies and ten attributes weredefined. Secondly, attributes were elaborated and developed by means of assessable parametersrelated to tunnel safety. Thirdly, the relative importance of the attributes was analysed and assessed bymean
Internal crowdsourcing offers new opportunities for ideas to gain legitimacy in idea development as not only managers but also experts are able to provide feedback to improve and subsequently accept ideas for further realisation. Given this far limited knowledge about how ideas gain legitimacy in idea development, this paper focuses on the influence of feedback, a main source of idea legitimacy in
Purpose: Accurate non-invasive prediction of histopathologic invasiveness and recurrence risk remains a clinical challenge in resectable non-small cell lung cancer (NSCLC). We developed and validated the Edge Proximity Score (EPS), a novel [18F]FDG PET/CT-based spatial imaging feature that quantifies the displacement of SUVmax relative to the tumor centroid and perimeter, to assess tumor aggressiv
