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Cochrane Sustainable Healthcare : evidence for action on too much medicine
Semiconductor-to-Metal Transition and Quasiparticle Renormalization in Doped Graphene Nanoribbons
A semiconductor-to-metal transition in N = 7 armchair graphene nanoribbons causes drastic changes in its electron and phonon system. By using angle-resolved photoemission spectroscopy of lithium-doped graphene nanoribbons, a quasiparticle band gap renormalization from 2.4 to 2.1 eV is observed. Reaching high doping levels (0.05 electrons per atom), it is found that the effective mass of the conduc
Direct Electron Transfer of Cellobiose Dehydrogenase on Positively Charged Polyethyleneimine Gold Nanoparticles (journal cover)
Invited for this month's cover is the group of Prof. Dr. Lo Gorton at Lund University, Sweden. The cover picture shows a biosensor for measuring lactose in dairy products. It consists of a gold electrode, onto which a layer of polyethyleneimine-capped gold nanoparticles is deposited. Read the full text of the article at 10.1002/cplu.201600453.
Dissecting nasopharyngeal cancer. Studies on prerequisites for antigen-specific active immunotherapy.
CDK9 Regulates Apoptosis of Myoblast Cells by Modulation of microRNA-1 Expression
Cdk9 is the catalytic core of the positive transcription elongation factor b (P-TEFb) and regulates transcriptional elongation factors by phosphorylation of RNA pol II. Apart from its role on myogenic gene expression, Cdk9 regulation of muscle-specific microRNAs in the early stage of cardiomyogenesis is poorly understood. Here we demonstrate that Cdk9 not only regulates myogenic transcription fact
High-accuracy modeling of antibody structures by a search for minimum-energy recombination of backbone fragments
Current methods for antibody structure prediction rely on sequence homology to known structures. Although this strategy often yields accurate predictions, models can be stereo-chemically strained. Here, we present a fully automated algorithm, called AbPredict, that disregards sequence homology, and instead uses a Monte Carlo search for low-energy conformations built from backbone segments and rigi
Synthesis of Cr(III) Salen Complexes as Supramolecular Catalytic Systems for Ring-Opening Reactions of Epoxides
The synthesis of two conformationally restricted Cr(III) salen complexes, 2 and 3, is described. Together, they constitute a supramolecular hydrogen-bonding catalytic system for the recently reported asymmetric ring-opening reactions of epoxides by a dynamic supramolecular catalyst. The synthesis involves state-of-the art transformations in frontline synthetic chemistry applied to heterocyclic che
Bridging the gap between theory and practice : Socio-technical toolbox
This paper describes a teaching experience of information systems (IS) analysis and design unit. In this unit every student applies a socio-technical (ST) toolbox in a real life business. These projects give students experience of real world business practices, issues and processes and provide opportunities to create a stimulating learning environment. At the same time the projects help involved b
Perturbed bone composition and integrity with disorganized osteoblast function in zinc receptor/Gpr39-deficient mice
Changes in bone matrix composition are frequently found with bone diseases and may be associated with increased fracture risk. Bone is rich in the trace element zinc. Zinc was established to play a significant role in the growth, development, and maintenance of healthy bones; however, the mechanisms underlying zinc effects on the integrity of the skeleton are poorly understood. Here, we show that
Modeling the effect of different dimensions in high contrast grating mirror
The reflectivity spectrum in Vertical-cavity surface-emitting lasers (VCSELs) is investigated by replacing High Contrast Grating (HCG) layer instead of distributed Bragg reflectors (DBR) as a top mirror. In addition, the scalability feature in the HCG layer is used to design a reflector for λ = 1;300 nm. High reflectivity (>99%) mirrors in VCSELs are mandatory because of the short gain length. In
Interactions in aqueous salt solutions : Atomistic modelling versus experiment
The research in this thesis investigates how atoms and molecules constituting aqueous salt solutions interact using computational approaches, namely Monte Carlo simulations and molecular dynamics simulations. In the first paper, an atomistic model was developed for aqueous solutions of sodium thiocyanate and potassium thiocyanate (NaSCN and KSCN). The model reproduced several experimentally measur
Detection of pro-apoptotic Bax∆2 proteins in the human cerebellum
BaxΔ2 sensitizes colorectal cancer cells to proteasome inhibitor-induced cell death
The functional domains for Bax∆2 aggregate-mediated caspase 8-dependent cell death
Deficiency in ubiquitin-like protein Ubl4A impairs migration of fibroblasts and macrophages
Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching
Northern Declarations of Freedom of the Press : The Relative Importance of Philosophical Ideas and of Local Politics
In recent works on the Enlightenment and the origin of modern Western thought, there is often a dichotomy between Moderate versus Radical Enlightenment. This essay evaluates the early experiences of freedom of print in Sweden and Denmark against the backdrop of such assertions. Sweden and Denmark were widely diverging polities but they obtained officially recognized freedom of the press at almost
BaxΔ2 Promotes Apoptosis through Caspase-8 Activation in Microsatellite-Unstable Colon Cancer
Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues
The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the reading frame is restored allowing production of a full-length protein (Bax∆2). Unlike the parental Baxα, Bax∆2 triggers apoptosis through a non-mitochondri