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Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Objective The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (93

Test Scheduling in an IEEE P1687 Environment with Resource and Power Constraints

In contrast to IEEE 1149.1, IEEE P1687 allows, through segment insertion bits, flexible scan paths for accessing on-chip instruments, such as test, debug, monitoring, measure- ment and configuration features. Flexible access to embedded instruments allows test time reduction, which is important at production test. However, the test access scheme should be carefully selected such that resource cons

Design of a novel biohythane process with high H2 and CH4 production rates

A biohythane process based on wheat straw including: i) pretreatment, ii) H2 production using Caldicellulosiruptor saccharolyticus, iii) CH4 production using an undefined consortium, and iv) gas upgrading using an amine solution, was assessed through process modelling including cost and energy analysis. According to simulations, a biohythane gas with the composition 46–57% H2, 43–54% CH4 and 0.4%

Habitat associations of the Coastal Giant Salamander (Dicamptodon Tenebrosus) at its northern range limit

Knowledge of species-environment associations is critical for the management of threatened amphibian populations facing habitat fragmentation and a restricted range. The Coastal Giant Salamander (Dicamptodon tenebrosus) is subject to habitat degradation from logging and human development and is classified as Threatened at its northern range limit in British Columbia, Canada. We examined habitat as

Self-Assembly of Polyion-Surfactant Ion Complex Salts in Mixtures with Water and n-Alcohols

Phase behavior and structural features were investigated for "complex salts", consisting of the cationic hexadecyltrimethylammonium (CTA) surfactant with polyacrylate (PA(n), n = 30 or 6000) counterions, mixed with water and different n-alcohols (ethanol, butanol, hexanol, octanol, and decanol). The liquid crystalline structures formed were identified by small-angle X-ray scattering measurements,

Spectral hole-burning spectroscopy in Nd3+: YVO4

We present spectral hole-burning measurements on the 879 nm, I-4(9/2) -> F-4(3/2) transition in Nd3+ : YVO4. We observe antiholes in the spectrum along with long lived spectral holes, which demonstrates optical pumping between the ground state Zeeman levels. The spectral holes are narrow (homogeneous linewidth of 63 kHz) at 2.1 K with a 300 mT applied magnetic field. We also perform preliminary sp

Electric field driven self-assembly of ionic microgels

We study, using fluorescent confocal laser scanning microscopy, the directed self-assembly of cross-linked ionic microgels under the influence of an applied alternating electric field at different effective packing fractions phi(eff) in real space. We present a detailed description of the contribution of the electric field to the soft interparticle potential, and its influence on the phase diagram

Gender differences in workers with identical repetitive industrial tasks: exposure and musculoskeletal disorders.

OBJECTIVES: For unknown reasons, females run a higher risk than males of work-related musculoskeletal disorders. The aim of this study was to evaluate whether male and female workers, with identical repetitive work tasks, differ concerning risk of disorders, physical or psychosocial exposures. METHODS: Employees in two industries were studied; one rubber manufacturing and one mechanical assembly p

Healthcare consumption, experiences of care and test of and intervention in frail old people. Implications for case management

The overall aim of thesis was to explore frail older people’s experiences of receiving healthcare and/or social services and to investigate healthcare consumption and costs in both men and women and in different age groups in the two years prior to the introduction of long-term municipal care. A second aim was to explore a preventive intervention in a pilot study using case managers to older peopl

Survival in cancer of unknown primary site: population-based analysis by site and histology

Cancer of unknown primary (CUP) is diagnosed at a metastatic stage, conferring an unfavorable prognosis. The natural history of the disease is poorly understood, which complicates diagnosis, treatment and follow-up. Population-based survival data are lacking regarding location and histology of metastases. From the Swedish Cancer Registry, 18 911 CUP patients were identified between years 1987 and

Clinical interest of postural and vestibulo-ocular reflex changes induced by cervical muscles and skull vibration in compensated unilateral vestibular lesion patients

Skull vibration induces nystagmus in unilateral vestibular lesion (UVL) patients. Vibration of skull, posterior cervical muscles or inferior limb muscles alters posture in recent UVL patients. This study aimed to investigate the postural effect of vibration in chronic compensated UVL patients. Vibration was applied successively to vertex, each mastoid, each side of posterior cervical muscles and o

Treatment with local hemostatic agents and primary closure after tooth extraction in warfarin treated patients.

The aim of this retrospective study was to assess the frequency of postoperative bleeding in patients on warfarin after tooth removal followed by a complete soft tissue closure of the surgical site. A total of 124 consecutive patients, 69 males and 55 females with a mean age of 71 years (range 28-95 years) were included in this study. Inclusion criteria were patients on warfarin with an INR

Equation of state and electronic properties of EuVO4: A high-pressure experimental and computational study

Structural, elastic and electronic properties of zircon-type and scheelite-type EuVO4 are investigated experimentally, by in-situ X-ray diffraction using synchrotron radiation, and theoretically within the framework of the density functional theory (DFT) and using the PBE prescription of the exchange-correlation energy. This study was motivated by the fact that the previous knowledge of the equati

MIR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.

Androgens and the androgen receptor (AR) play crucial roles in male development and the pathogenesis and progression of prostate cancer (PCa). The AR functions as a ligand dependent transcription factor which recruits multiple enzymatically distinct epigenetic coregulators to facilitate transcriptional regulation in response to androgens. Over-expression of AR coregulators is implicated in cancer.

Double-Edged Counter-Narratives: Cosmology and Indigenous Rights in the Bolivian Andes

This paper looks into indigenous Aymara notions of ‘the strange’ and ‘the proper’ and examines how such notions are articulated in an indigenous criticism of a persistently colonial modernity. Such criticism is double-edged. On the one hand, it is articulated in a mythological idiom referring to conceptions of profound cosmological import and this paper delves into how such criticism is grounded i