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Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin. We report the characterization of several new variants of collybistin, which are created by alternative splicing of exons encoding an N-terminal src homology 3 (SH3) domain
BACKGROUND AND OBJECTIVES: The published sequence of the weak. A subgroup Ael gene from Swedish individuals showed a G insertion in exon VII, causing a frameshift at codon 268 (the A1 gene has 353 codons). We wished to sequence exons VI and VII of two Norwegian Ael individuals and compare the expression of A substance on RBC from different Ael individuals. MATERIALS AND METHODS: Exon VI and VII we
Personers reaktioner har studerats genom experimentella studier samt i genomgång av litteraturen. I denna undersökning har valet av utrymningsväg vid en simulerad brand studerats utifrån olika förutsättningar vad avser avstånd till utrymningsvägen och om dörren var öppen eller stängd. En andra del i försöket studerade hur personer reagerade och uppfattade situationen om en liten brand befann sig mHow people react on fire alarm have been studied in retrospect as well as in experiments. In the present study, the choice of exit was examined with respect to the distance to exits and open or closed emergency exit. The second part covers the question on how the subjects think and react in a situation having a small fire in the escape route. The third part deals with some communication aspects re
Popular Abstract in Swedish Primärt Sjögrens syndrom är en reumatisk systemsjukdom, som karaktäriseras av nedsatt funktion i vissa körtlar, framför allt i tårkörtlar och spottkörtlar. Detta orsakar huvudsymptomen ögon- och muntorrhet. Patienter med denna sjukdom har även besvär som inte är relaterade till dessa körtlar. Smärta i leder och muskler, extrem trötthet samt nedstämdhet är vanliga problePrimary Sjögren´s syndrome (primary SS) is a systemic autoimmune rheumatic disease characterized by lymphocytic infiltrations in the exocrine glands leading to classic dryness complaints such as dry eyes and dry mouth. Non-exocrine complaints also occur, e.g. fatigue, myalgia and arthralgia, as well as disturbed mood. The overall purpose of this work was, from a physiotherapeutic perspective, to i
To investigate whether factors in the fetal or neonatal period influence the risk of later development of coeliac disease we conducted a population-based register study. The Swedish Medical Birth Register was linked with the Hospital Discharge Register and identified 3392 singleton infants born in the period 1987-97 who developed coeliac disease. Perinatal data for these children were compared wit
BACKGROUND: The Knee injury and Osteoarthritis Outcome Score (KOOS) is an extension of the Western Ontario and McMaster Universities Osteoarthrtis Index (WOMAC), the most commonly used outcome instrument for assessment of patient-relevant treatment effects in osteoarthritis. KOOS was developed for younger and/or more active patients with knee injury and knee osteoarthritis and has in previous stud
Fluorescence lifetimes of formaldehyde excited by picosecond laser radiation with a wavelength of 355 nm were determined in nitrogen gas in a cell using time-resolved laser-induced fluorescence spectroscopy. The measurements were conducted at temperatures between 295 and 770 K and pressures up to 10 bar (1 MPa). Detection was broadband in most cases. Temperature and pressure were found to have a q
Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Methods. DA rats with established CIA were treated with corticosteroids (betamethasone, 0.1 mg/kg body weight) or placebo (saline) intraperitoneally once
We evaluated 2 consecutive cohorts of patients with primary trapeziometacarpal arthrosis 1 year after either first metacarpal osteotomy or trapezial excision with abductor pollicis longus tendon arthroplasty. At follow-up, 4 of 7 patients treated with osteotomy had pain at rest and/or with light activities and were dissatisfied with the results of surgery, all 4 had advanced (stage III) preoperati
This paper argues in line with recent work by Pesetsky and Torrego that given the operation Agree there is no need for the concept Abstract Case in Narrow Syntax. Morphological case exists in many languages, and is here, following a suggestion by Halldór Sigurðsson, seen as the result of an instruction to PF how to translate syntactic structure into morphology. I will call this instruction CAM, sh
We present a general model study of surface-enhanced resonant Raman scattering and fluorescence, focusing on the interplay between electromagnetic (EM) effects and the molecular dynamics as treated by a density matrix calculation. The model molecule has two electronic levels, is affected by radiative and nonradiative damping mechanisms, and a Franck-Condon mechanism yields electron-vibration coupl
OBJECTIVE: Limited data concerning serum lipids and lipoproteins are available on the effect of HRT in perimenopausal women, who commonly have marked bleeding disturbances and may have severe climacteric symptoms. Almost all previously published data have utilized a simplified form of lipoprotein analysis, which includes an estimation and not a determination of LDL cholesterol. To delineate the ro
Geographical variations in cardiovascular mortality have been reported from Mid-Sweden. IHD mortality for men aged 45-64 was 60% higher in the western part than in the east. Mortality from stroke for men aged 45-74 was 73% higher on the west. Similar differences were found for women. One possible explanation could be that there are no incidence differences but that the mortality differences are du
OBJECTIVES: To examine cardiovascular physiology in the healthy fetus during normal development. DESIGN: Twenty normal fetuses were studied longitudinally from 20 weeks to term. Serial echocardiography was performed, and arterial and venous diameter pulse wave characteristics and aortic pulse wave propagation velocity (PWV) were examined in the thoracic descending aorta (AoD) and inferior caval ve
