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Defect Free PbTe Nanowires Grown by Molecular Beam Epitaxy on GaAs(111)B Substrates

The molecular beam epitaxial growth of PbTe nanowires oil GaAs(111)B substrates is reported. The growth process was based oil the Au-catalyzed vapor-liquid-solid mechanism. These nanowires grow along the [100] axis; they are perpendicular to the substrate, have tapered shapes, and have diameters of about 90 rim at the base and 60 run at the top. High resolution transmission electron microscopy pic

Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface.

The kinin B1 receptor (B1R) is a G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult. Here, we investigated if B1R homo-oligomerization is a possible mechanism regulating the presentation of this receptor at the level of maturation and trafficking to the cell surface. To this end, we used HEK293 cells stably expressing N-terminal

Antimicrobial activity of peptides derived from human ß-amyloid precursor protein.

Antimicrobial peptides are important effector molecules of the innate immune system. Here, we describe that peptides derived from the heparin-binding disulfide-constrained loop region of human ß-amyloid precursor protein are antimicrobial. The peptides investigated were linear and cyclic forms of NWCKRGRKQCKTHPH (NWC15) as well as the cyclic form comprising the C-terminal hydrophobic amino acid ex

Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr(-/-) Mice Compared to Nondiabetic LDLr(-/-) Mice.

Background. Diabetes is associated with increased cardiovascular disease, but the underlying cellular and molecular mechanisms are poorly understood. One proposed mechanism is that diabetes aggravates atherosclerosis by enhancing plaque inflammation. The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Here we investigate the development of ath

A cross-contamination-free SELEX platform for a multi-target selection strategy

Multi-target aptamer selection, known as multiplex systematic evolution of ligands by exponential enrichment (SELEX), is rapidly drawing interest because of its potential to enable high-speed, high-throughput aptamer selection. The parallelization of chemical processes by integrating microfluidic unit operations is a key strategy for developing a multiplex SELEX process. One of the potential probl

"m=1" coatings for neutron guides

A substantial fraction of the price for a supermirror neutron guide system is the shielding, which is needed because of the gamma radiation produced as a result of neutron absorption in the supermirror layers. Traditional coatings have been made of nickel-titanium heterostructures, but Ni and Ti also have a fairly high absorption cross section for cold and thermal neutrons. We examine a number of

Two-loop sunset integrals at finite volume

We show how to compute the two-loop sunset integrals at finite volume, for non-degenerate masses and non-zero momentum. We present results for all integrals that appear in the Chiral Perturbation Theory (chi PT) calculation of the pseudoscalar meson masses and decay constants at next-to-next-to-leading order, including the case of Partially Quenched chi PT. We also provide numerical implementation

Electrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans

When exposed to intermediate glucose concentrations (6-16 mol/l), pancreatic beta-cells in intact islets generate bursts of action potentials (superimposed on depolarised plateaux) separated by repolarised electrically silent intervals. First described more than 40 years ago, these oscillations have continued to intrigue beta-cell electrophysiologists. To date, most studies of beta-cell ion channe

A Capacity Constrained Production-Inventory System with Stochastic Demand and Production Times

This paper considers a simple model of a capacity constrained production-inventory system with Poisson demand. The system is controlled by an S policy. The production time for a unit is modelled as a gamma distributed stochastic variable. Using M/G/1 queuing theory it is very easy to evaluate holding and backorder costs and optimise the ordering policy. The suggested model may be useful when evalu

Eemian interglacial reconstructed from a Greenland folded ice core

Efforts to extract a Greenland ice core with a complete record of the Eemian interglacial (130,000 to 115,000 years ago) have until now been unsuccessful. The response of the Greenland ice sheet to the warmer-than-present climate of the Eemian has thus remained unclear. Here we present the new North Greenland Eemian Ice Drilling ('NEEM') ice core and show only a modest ice-sheet response to the st

Permanent Genetic Resources added to Molecular Ecology Resources Database 1 February 2011-31 March 2011.

This article documents the addition of 111 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Acipenser oxyrinchus desotoi, Anopheles nuneztovari sensu lato, Asellus aquaticus, Calopteryx splendens, Calopteryx virgo, Centaurea aspera, Centaurea seridis, Chilina dombeyana, Proctoeces cf. lintoni and Pyrenophora teres f. teres.

Parameter selection methods for axisymmetric flame tomography through Tikhonov regularization

Deconvolution of optically collected axisymmetric flame data is equivalent to solving an ill-posed problem subject to severe error amplification. Tikhonov regularization has recently been shown to be well suited for stabilizing this deconvolution, although the success of this method hinges on choosing a suitable regularization parameter. Incorporating a parameter selection scheme transforms this t

HEP Applications and Their Experience with the Use of DataGrid Middleware

An overview is presented of the characteristics of HEP computing and its mapping to the Grid paradigm. This is followed by a synopsis of the main experiences and lessons learned by HEP experiments in their use of DataGrid middleware using both the EDG application testbed and the LCG production service. Particular reference is made to experiment lsquodata challengesrsquo, and a forward look is give

Clay Intercalation and its Influence on the Morphology and Transport Properties of EVA/Clay Nanocomposites

Nanocomposite membranes based on poly-(ethylene-co-vinyl acetate) copolymer (18% vinyl acetate content)and two different organomodified clays have been prepared by mechanical mixing using two roll mill method. The morphology of the nanocomposites was investigated using small angle X-ray scattering, scanning electron microscopy, and transmission electron microscopy. The mechanical and thermal studi

The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest

Introduction: Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain injury and predict outcome. In this study, we evaluated the impact of the cardiac arrest syndrome on the plasma levels of selected tissue-specific microRNAs (miRNAs) and assessed their ability to prognosticate death and neurological

Integrating timescales with time-transfer functions: A practical approach for an INTIMATE database

The purpose of the INTIMATE project is to integrate palaeo-climate information from terrestrial, ice and marine records so that the timing of environmental response to climate forcing can be compared in both space and time. One of the key difficulties in doing this is the range of different methods of dating that can be used across different disciplines. For this reason, one of the main outputs of

Caries risk profiles in schoolchildren over 2 years assessed by Cariogram

Background. Caries risk assessment is an important tool in clinical decision making. Aim. To evaluate longitudinal changes in caries risk profiles in a group of schoolchildren in relation to caries development. Design. The Cariogram model was used to create caries risk profiles and to identify risk factors in 438 children being 10-11 years at baseline. The assessment was repeated after 2 years and