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PYTHIA version 7-0.0 - a proof-of-concept version

This document describes the first proof-of-concept version of the PYTHIA7 program. PYTHIA7 is a complete re-write of the PYTHIA program in C++. It is mainly intended to be a replacement for the `Lund' family of event generators, but is also a framework with a structure suitable for implementing any event generator model. In this document, the structure of the program is presented both from the use

QCD radiation off heavy particles

We study QCD radiation in decay processes involving heavy particles. As input, the first-order gluon emission rate is calculated in a number of reactions, and comparisons of the energy flow patterns show a non-negligible process dependence. To proceed further, the QCD parton shower language offers a convenient approach to include multi-gluon emission effects, and to describe exclusive event proper

New and old jet clustering algorithms for electron-positron events

Over the years, many jet clustering algorithms have been proposed for the analysis of hadronic final states in e+e- annihilations. These have somewhat different emphasis and are therefore more or less suited for various applications. We here review some of the most used and compare them from a theoretical and experimental point of view.

Modeling Bose-Einstein correlations at LEP-2

We present new algorithms for simulating Bose–Einstein correlations among final-state bosons in an event generator. The algorithms are all based on introducing Bose–Einstein correlations as a shift of final-state momenta among identical bosons, and differ only in the way energy and momentum conservation is ensured. The benefits and shortcomings of this approach, that may be viewed as a local rewei

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

Identification and characterization of a novel botulinum neurotoxin

Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2 and 3, but at a novel site (Arg66-Ala67 in VAMP2). Remarkably, BoNT/X

The structure of the tetanus toxin reveals pH-mediated domain dynamics

The tetanus neurotoxin (TeNT) is a highly potent toxin produced by Clostridium tetani that inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus disease. TeNT differs from the other clostridial neurotoxins by its unique ability to target the central nervous system by retrograde axonal transport. The crystal structure of the tetanus toxin reveals a "closed"

Upper-bound computation for optimal retargeting in IEEE1687 networks

IEEE 1687 enables flexible access to on-chip instruments via dynamically reconfigurable networks. Reconfiguration allows reducing instrument access time by keeping only those instruments on the scan-path which are required for each access. To perform reconfiguration and execute commands described in instrument access procedures, scan vectors are generated in a process called retargeting. These vec

Essays in Applied Microeconomics

This thesis consists of four self-contained papers in applied microeconomics. The first paper asks how a neighbors purchase of a specific good affects a households likelihood of purchase. I use an image classification algorithm to process a large set of aerial photos in order to infer household ownership of a visible durable good, specifically a trampoline. To estimate the neighborhood effect, I u

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. We comprehensively show that loss of

Blockchains, Real-time Accounting, and the Future of Credit Risk Modeling

In this paper I discuss how blockchains potentially could affect the way creditrisk is modeled, and how the improved trust and timing associated with blockchain-enabled real-time accounting could improve default prediction. To demonstrate the (quite substantial) effect the change would have on well-known credit risk measures, a simple case-study compares Z-scores and Merton distances to default coIn this paper I discuss how blockchains potentially could affect the way credit risk is modeled, and how the improved trust and timing associated with blockchain-enabled real-time accounting could improve default prediction. To demonstrate the (quite substantial) effect the change would have on well-known credit risk measures, a simple case-study compares Z-scores and Merton distances to default c

Understanding one’s body and movements - from the perspective of young adults with autism

Background: There are but a few studies of how persons with autism perceive and experience their bodies and movements. Having autism may mean difficulty with verbalizing these experiences. Difficulties in perceiving the surrounding world along with disturbed motor coordination and executive functions may affect physical and psychological development. Exploring possibilities to capture the experien

Helsingborg i våra händer

Artikeln problematiseras hur bilder skapas av städer med utgångspunkt i Helsingborg. Artikeln är skriven utifrån fotografen Tom Walls bilder av Helsingborg förr och nu.

"Producing People" in Documents and Meetings in Human Service Organizations

This thematic issue is devoted to how human service work may be influenced by accentuated administrative processes, as well as reinforced by digitalization, in contemporary society. The public sector has expanded the requirements of documentation, auditing and evaluation practices. Policy, problems and persons are shaped and enacted in meetings and documents. Meetings and documents comprise the fo