Hematopoietic stem cell (HSC) based gene therapy offers the possibility of permanent correction for genetic disorders of the hematopoietic system. However, optimization of present protocols is required before gene therapy can be safely applied as general treatment of genetic diseases. In this study we have used a mouse model of type 1 Gaucher disease (GD) to demonstrate the feasibility of a low-ri

Innehåll: Ledare (Michael Tapper), Bakom Glädjekällan: Intervju med Richard Hobert (Michael Tapper), Hong Kong erövrar världen (Chi An Gramfors), Chris Marker: "...prototypen för 2000-talets människa" (Pelle Snickars), Populisten: John Grisham - romaner och filmer (Magnus Eriksson), Från nationens födelse till gränslandsmytens död: Hollywood och den nationella identiteten (Ulf Zander), New Hollywo

Innehåll: Ledare (Michael Tapper), Film, filmhistoria och intertextualitet: En teoretisk översikt (Erik Hedling), Scream: En intertextuell slasherfilm (Helle Kannik Haastrup), Den autentiska stilen: Dokumentära grepp i svensk fiktionsfilm på 1960- och 1070-talen (Cecilia Mörner), Rysk animation efter perestrojka (Michail Bousnjouk). Recensioner: bio, laseskivor, böcker.

Temanummer om film på 1990-talet. Innehåll: Ledare (Michael Tapper), En kompassriktning i den moraliska snårskogen: Den brittiska filmens 1990-tal (Robert Murphy), Om den nya vågen och Dogma95 i dansk film: Är det bara en skakig kamera och en suddig bild som avgör? (Birger Langkjaer), Nittiotalism: En snitslad bana genom tio år av dramaproduktion på SVT (Anders Åberg), Kriminalfilmer i 1990-talets

Innehåll: Ledare (Michael Tapper), Filmkonstens politik och mytologi: Abraham Polonsky och film noir (Paul Buhle & Dave Wagner), Vit melodram: Douglas Sirk 1897-1987 (Tag Gallagher), Passion: Hitchcock, Alma och filmen 1921-1925 (Patrick McGilligan), Konstnärligt ambitiös film och amerikansk dussinfilm: Ett exempel på det tidiga sextiotalets syn på film som konst i den intellektuella debatten

Innehåll: Ledare (Michael Tapper), Pedanten åker till Hollywood: En rådgivande akademikers roll (Kathleen M Coleman), Gladiator (Alexander MacGregor), Orson Welles som historiker, Orson Welles som historia: Citizen Kane, RKO 281 och Cradle Will Rock (Arthur M Eckstein), Det brinner en eld: Gustaf Molander och andra världskriget (Bengt Forslund), Michael Haneke: Bortom alla kompromisser (Robin Wood

Innehåll: Ledare (Michael Tapper), Vilgot Sjömans Troll: Det förverkligade psykodramat (Anders Åberg), White Line Nightmare: Mad Max och jordens undergång (John Baxter), Visuell masskultur under det glada 1890-talet (Pelle Snickars). Tema Éric Rohmer: Om Éric Rohmers Tre män och en kärlek (Stanley Cavell), Filosofiska tankar i Éric Rohmers filmer (William Rothman), Förlorad och återfunnen: Éric Ro

Objectives Whether the increased risk of comorbidities, such as cardiovascular disease, in rheumatoid arthritis (RA) can be reverted by particular antirheumatic therapies, or response to these, is unclear but of critical clinical importance. We wanted to investigate whether response to tumour necrosis factor inhibitors (TNFi) translates into a reduced risk for acute coronary syndrome (ACS). Method

The present contribution presents event-related potential (ERP) and functional magnetic resonance imaging (fMRI) findings related to the processing of Swedish word accents. These results are then discussed and further analysed in the context of models of word activations and phonological neighbourhoods. It has previously been seen that word accents (either a low tone (accent 1) or a high tone (acc

This text aims at exploring the relationship between a more equitable sharing of the responsibility for protection seekers and the normative framework on refugees and immigration already existing in Europe.

Aims: Climate change is known to drive both the reshuffling of whole assemblages and range shifts of individual species. Less is known about how local colonizations and extinctions of individual species contribute to changes at the community level. Our aim was to estimate the contribution of individual species to a change in community composition attributed to climate change and to relate these sp

Film International (published by Intellect, Bristol, UK) is dedicating a special journal issue to “Making Movies in Europe: Production, Industry, Policy” and cordially invites proposals on this theme. Studies of contemporary as well as historical filmmaking practices are welcome. Possible areas include, but are not limited to:-the specific workings of national cinema industries (e.g. specific nati

We consider the problem of link capacity dimensioning and bandwidth allocation in networks that support elastic flows and maintain proportional fairness among these flows. We assume that a certain allocated bandwidth to a user demand generates revenue for the network operator. On the other hand, the operator incurs a capacity dependent cost for each link in the network. The operator's profit is th

Fuel cells produce low quantities of local emissions, if any, and are therefore one of the most promising alternatives to internal combustion engines as the main power source in future vehicles. It is likely that urban buses will be among the first commercial applications for fuel cells in vehicles. This is due to the fact that urban buses are highly visible for the public, they contribute signifi

Contents: Women, Religion and the Video Film in Nigeria (Onookome Okome), Craig Baldwin: A Visual Essay (Patrik Sjöberg), Revenge Is Sweet: The Bitterness of Audition (Robin Wood), British Film Noir: Dark Shadows Around Pinewood and Ealing (Robert Murphy), Heroes: Otto Preminger (Tag Gallagher). Reviews: books, dvds.

Bark beetles face challenges and trade-offs during host selection, imposed by lethal tree defences, lower nutrition and higher competition in less well-defended trees, scarcity and ephemeral distribution of susceptible hosts, limitation of suitable hosts to one beetle generation, and relatively short lifespan and vulnerability of adults during host searching. Beetles contend with these challenges

The release of toxic gases due to natural/industrial accidents or terrorist attacks in populated areas can have tragic consequences. To prevent and evaluate the effects of these disasters different approaches and modelling tools have been introduced in the literature. These instruments are valuable tools for risk managers doing risk assessment of threatened areas. Despite the significant improveme