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A Markov model approach shows a large variation in the length of S phase in MCF-7 breast cancer cells

Background: The potential doubling time of a tumor has been suggested to be a measurement of tumor aggressiveness; therefore, it is of interest to find reliable methods to estimate this time. Because of variability in length of the various cell cycle phases, stochastic modeling of the cell cycle might be a suitable approach. Methods: The relative movement curve and the DNA synthesis time were esti

A key recovery attack on Edon80

Edon80 is a recent stream cipher design that has advanced to the third and last phase of the eSTREAM project. It has remained unbroken and untweaked since it was designed and submitted to eSTREAM. It is now one of the 8 final hardware candidates. In this paper we cryptanalyze the cipher by describing a key recovery attack. The complexity of the attack is around 269 simple operations for a keystrea

Age of SERPINA1 gene PI Z mutation: Swedish and Latvian population analysis

Alpha 1-antitrypsin (A1AT) deficiency, one of the most common inborn errors of metabolism in Caucasians, is characterized by a low serum concentration of A1AT and a high risk of pulmonary emphysema and liver disease. The allelic frequency for the most common protease inhibitor (PI) Z mutation in the SERPINA1 gene is 2-5% in Caucasians of European descent. The objective of our study was to estimate

Fuzzy traceability: A process simulation derived extension of the traceability concept in continuous food processing

Abstract in Undetermined Liquid food production often involves continuous processing. This leads to problems in traceability systems due to mixing zones and therefore indistinct batch identities causing difficulties with regard to withdrawals or recalls. This article outlines the possible use of the concept of dynamic simulation to improve the handling of batch identities in continuous production

Penetrative ductile deformation and amphibolite-facies metamorphism prior to 1851 Ma in the western part of the Svecofennian orogen, Fennoscandian Shield

The Svecofennian orogen in the Fennosandian Shield consists of several Palaeoproterozoic meta-igneous provinces that generally young progressively southwards and westwards. The understanding of the tectonic evolution of these different provinces is linked to the ability to constrain the timing of ductile deformation and metamorphism within them. In the western part of the orogen, in central Sweden

Family relations, adjustment and wellbeing in a longitudinal study of children in care

The article reports on a longitudinal study of children placed in a children's home during the first two years of the 1980s. The 26 children placed when younger than 4 years of age and staying more than 4 weeks were followed up 3 and 9 months after leaving the children's home and 5, 10, 15 and 20 years later. The children's family relations, including early attachments and later parental relations

Opportunities of student influence as a context for the development of engineering students' study motivation.

This longitudinal paper draws on data from a larger ongoing project and examines how students conceive of their opportunities to influence their study environment and how this may be related to their self-efficacy beliefs and their study motivation. Interpretative Phenomenological Analysis (IPA) was used to analyze semi-structured in-depth interviews of 10 students of a Masters Program in Engineer

Prophylaxis for severe haemophilia: clinical challenges in the absence as well as in the presence of inhibitors

Prophylaxis is defined as the regular administration of clotting factor concentrates to prevent bleeding. Extensive data from observational studies and a recent randomized controlled trial (have established that early prophylactic treatment prevents bleeds and arthropathy in boys with severe haemophilia. The initiation of prophylaxis in young children remains challenging. To prevent arthropathy, p

Regioselectivity in aqueous palladium catalysed hydroxycarbonylation of styrene: a catalytic and mechanistic study

Regioselectivity control was studied in palladium catalysed hydroxycarbonylation of styrene in neat water with water-soluble phosphines, mostly trisulfonated triphenylphosphine, TPPTS, but also N-bis(N', N'-diethyl-2-aminoethyl)-4-aminomethylphenyl-diphenylphosphine, N3P. The factor giving the highest changes in regioselectivity in the TPPTS system, under similar reaction conditions, is the temper

Kinematic hardening in large strain plasticity

A finite strain hyper elasto-plastic constitutive model capable to describe non-linear kinematic hardening as well as nonlinear isotropic hardening is presented. In addition to the intermediate configuration and in order to model kinematic hardening, an additional configuration is introduced - the center configuration; both configurations are chosen to be isoclinic. The yield condition is formulat

Tracking carbon from the atmosphere to the rhizosphere

Turnover rates of arbuscular mycorrhizal (AM) fungi may influence storage of soil organic carbon (SOC). We examined the longevity of AM hyphae in monoxenic cultures; and we also used C-13 incorporation into signature fatty acids to study C dynamics in a mycorrhizal symbiosis involving Glomus intraradices and Plantago lanceolata. C-13 enrichment of signature fatty acids showed rapid transfer of pla

Midterm changes in aortic aneurysm morphology after endovascular repair

PURPOSE: To study midterm changes in aortic aneurysm morphology after endovascular aneurysm repair. METHODS: Of 94 patients with abdominal aortic aneurysms (AAAs) treated with endografts between November 1993 and August 1998, 84 were available for follow-up. Patients were evaluated preoperatively by spiral computed tomography (CT) and aortography; in follow-up, spiral CT scanning was performed at

Irrigation of landfill leachates in energy forests - A technique to recover nutrients from municipal solid wastes

From an ecological point of view it is important to close nutrient cycles by recirculating mineral nutrients from the urban society back to agriculture and forestry, and thereby obtaining a sustainable resource utilisation. A part of this cycle is illustrated by irrigation of bioreactor landfill leachates on short rotation forests. This paper presents a budget for nutrients and heavy metals, begin

Stuttering and the basal ganglia circuits: a critical review of possible relations.

The possible relation between stuttering and the basal ganglia is discussed. Important clues to the pathophysiology of stuttering are given by conditions known to alleviate dysfluency, like the rhythm effect, chorus speech, and singing. Information regarding pharmacologic trials, lesion studies, brain imaging, genetics, and developmental changes of the nervous system is reviewed. The symptoms of s