We have previously identified C1 domain-containing phosphatase and TENsin homologue (C1-TEN) as being an intracellular binding partner for Axl receptor tyrosine kinase (RTK). C1-TEN is a tensin-related protein that houses an N-terminal region with predicted structural similarity to PTEN. Here, we report our observations on the effects of ectopic expression of C1-TEN in HEK293 cells, which resulted

A simple and efficient synthetic route to the bicyclic alpha,beta-unsaturated beta-keto ester methyl (3aS,7aS)-6-oxo-2,3,3a,6,7,7ahexahydro-1H-indene-5-carboxylate, a versatile intermediate in the synthesis of biologically active unsaturated 1,4-dialdehydes, is described. The synthesis includes a chirality introducing nonenzymatic asymmetric desymmetrization (ADS) reaction of a cyclic nieso-anhydr

Objectives: Due to the increased diagnosis of prostate cancer at earlier stages and the overall increased use of hormone therapy, also in earlier disease stages, many patients will receive long-term hormone therapy. Therefore, the timing of initiating hormone therapy and the type of hormone therapy have become crucial items in the appropriate management of patients with prostate cancer. in additio

A recent new strategy for the transformation of mono-dioxolane protected 1,3-cyclohexadione into bridgehead hydroxyl bicyclo[2.2.2]octane derivatives, based on allylindation followed by ozonolysis and intramolecular aldol addition, was modified to include asymmetric allylindation. This enabled the first enantioselective synthesis of (1R,4R,6S)-endo-4-(tert-butyl-dimethyl-silyloxy)-6-hydroxy-bicycl

The Na-33 beta decay was studied online using mass separation techniques and a first description of the level structure of the neutron-rich isotope Mg-33, with N=21, has been obtained. The experiment involved the measurement of beta-gamma, beta-gamma-gamma, and beta -n-gamma coincidences as well as neutron spectra by time-of-flight technique. The first low energy level scheme for the daughter nucl

OBJECTIVES: Small abdominal aortic aneurysms (AAA) are usually managed conservatively by serial ultrasound examinations to assess size. The development of the size of the AAA will determine whether the patient is a candidate for surgery. The precision of measurement is therefore of considerable importance. The aim of this study was to evaluate the accuracy and the reproducibility of a newly develo

Pollen records from a small lake and a small peatland at Ire in northern Blekinge, Sweden, reveal that until A.D. 300 there was a mixed deciduous type of woodland dominated by Quercus, Tilia and Corylus, with Betula, Pinus, Populus, Fraxinus, Ulmus and Acer as important constituents. The first, but weak, signs of human influence on the vegetation are detected around 2300 B.C. At this time, the are

Experiments were done to examine the phototrophic response of sun-tracking leaves of Lupinus succulentus Dougl. to fixed beams of white and broad band light. Upon irradiation with 15 W m-2 white light that struck the laminae at an angle of 45°, there was a 45–60 min lag period prior to leaf movement. The greatest rate of movement was 15° h-1, and reorientation ceased when leaves attained a positio

Conclusions. The presented analysis of nasal polyposis using connectivity based on the PubGene literature co-citation network demonstrates that this tool can be used to identify key genes in DNA microarray studies of human polygenic diseases. Objectives. DNA microarray studies of complex diseases may reveal differential expression of hundreds of genes. According to network theory and studies of ye

Popular Abstract in Swedish Avhandlingen består av tre essäer som behandlar effekterna av inkomplett information i de finansiella marknaderna. Av dessa essäer är två teoretiska och en är huvudsakligen empirisk. Samtliga essäer undersöker effekterna av parameterosäkerhet, och de använder sig av kontinuerliga modeller. Den första essän, "The Effect of Information Quality on Optimal Portfolio ChoiceThis thesis consists of three essays on incomplete information in financial markets, two of which are theoretical, and one that is mainly of an empirical nature. All three essays concern parameter uncertainty, and they employ a continuous-time framework. The first essay, "The Effect of Information Quality on Optimal Portfolio Choice," analyzes the portfolio choices made by three types of agents,

The tradition of writing books specifically for girls came to an abrupt end in the middle of the 1960's. In Sweden this was a turbulent decade when society changed in many ways, and equality between the sexes was a key word. The old girls' and boys' books were replaced by "the modern book for young people", which, it was proclaimed, should be up-to-date, discuss real problems, break taboos, and ap

The vascular-injuring amino acid homocysteine was previously shown to be increased in plasma in type 1 diabetic patients with clinical signs of nephropathy. Previous studies have also shown an inconsistent relationship between the development of diabetic nephropathy and retinopathy, indicating different pathogenetic mechanisms. In this study, plasma homocysteine was measured in 25 type 1 diabetic