Von Willebrand Disease: Mutations, Von Willebrand Factor Variance and Genetic Drift
The most commonly inherited bleeding disorder in humans is the von Willebrand disease (VWD), which is categorized into Type 1, Type 2 (with subtypes 2A, 2B, 2M and 2N) and Type 3 (Chen et al., 2016). In order to acquire a better method for its diagnosis, first the mutations causing the different types of the disorder were recorded. Secondly, the variance in the concentration of the von Willebrand