Through the European Research Initiative in CLL (ERIC), we screened 3490 patients with chronic lymphocytic leukemia (CLL) for mutations within the NOTCH1 (n=3334), SF3B1 (n=2322), TP53 (n=2309), MYD88 (n=1080) and BIRC3 (n=919) genes, mainly at diagnosis (75%) and prior to treatment (>90%). BIRC3 mutations (2.5%) were associated with unmutated IGHV genes (U-CLL), del(11q) and trisomy 12, whereas M

Nanoparticles with an internal structure have been prepared by dispersing under dilute conditions poly(acrylic acid) with a polymerization degree n = 6000 (PAA6000) together with a cationic surfactant hexadecyltrimethylammonium hydroxide (C16TAOH) and the non-ionic surfactant penta(ethylene glycol) monododecyl ether (C12E5) in water. The nanoparticles are formed at different mixing ratios in the c

Cellobiose dehydrogenase (CDH) is an emerging enzyme in the field of bioelectrocatalysis. Due to its flexible cytochrome domain, which acts as a built-in redox mediator, CDH is capable of direct electron transfer (DET) to electrode surfaces. This rare property is employed in mediatorless "third generation" biosensors. The ability of Corynascus thermophilus CDH to oxidize glucose under physiologica

In many cities of the world, road space is increasingly contested. Growing vehicle numbers, traffic calming and the development of new infrastructure for more sustainable transport modes such as bicycles have all contributed to pressure on available space and conflicts over the allocation of space. This paper provides the first assessment of urban transport infrastructure space distribution, disti

We demonstrate theoretically how local strains in graphene can be tailored to generate a valley-polarized current. By suitable engineering of local strain profiles, we find that electrons in opposite valleys (K or K') show different Brewster-like angles and Goos-Hanchen shifts, exhibiting a close analogy with light propagating behavior. In a strain-induced waveguide, electrons in K and K' valleys

We present a global dataset of CO2 emissions and O2 uptake associated with the combustion of different fossil fuel types. To derive spatial and temporal patterns of oxygen uptake, we combined high-resolution CO2 emissions from the EDGAR (Emission Database for Global Atmospheric Research) inventory with country level information on oxidative ratios, based on fossil fuel consumption data from the UN

Background: Cardiovascular Magnetic Resonance (CMR) enables non-invasive quantification of cardiac output (CO) and thereby cardiac index (CI, CO indexed to body surface area). The aim of this study was to establish if CI decreases with age and compare the values to CI for athletes and for patients with congestive heart failure (CHF). Methods: CI was measured in 144 healthy volunteers (39 +/- 16 ye

Contradictory results have been reported on the relationship between orthostatic hypotension (OH) and mild cognitive impairment (MCI).

Rationale: IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. Objectives: The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier studies focused on the role of IL-9 in acute inflammatory models; here we have in

A search for the decay to a pair of new particles of either the 125 GeV Higgs boson (h) or a second charge parity (CP)-even Higgs boson (H) is presented. The data set corresponds to an integrated luminosity of 20.3 fb(-1) of pp collisions at root s = 8 TeV recorded by the ATLAS experiment at the LHC in 2012. The search was done in the context of the next-to-minimal supersymmetric standard model, i

IMPORTANCE Follow-up at 30 months' corrected age reveals eye and visual problems in one-third of children born extremely prematurely (

Movement is a fundamental behaviour of organisms that not only brings about beneficial encounters with resources and mates, but also at the same time exposes the organism to dangerous encounters with predators. The movement patterns adopted by organisms should reflect a balance between these contrasting processes. This trade-off can be hypothesized as being evident in the behaviour of plankton, wh

The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in relation to genetic risk profiles in diabetic and nondiabetic donors. Islets from donors with T2D ex

To investigate the association between cohabitation status, clinical stage at diagnosis, and disease-specific survival in cutaneous malignant melanoma (CMM).

The water interactions of polymer electrolyte membranes are of significant interest when these materials are used in for example fuel cells. We have therefore studied the sorption thermodynamics of Nafion 117 with a sorption calorimeter that simultaneously measures the sorption isotherm and the mixing (sorption) enthalpy. This unique method is suitable for investigating the sorption thermodynamics

Detection turning points in unimodel has various applications to time series which have cyclic periods. Related techniques are widely explored in the field of statistical surveillance, that is, on-line turning point detection procedures. This paper will first present a power controlled turning point detection method based on the theory of the likelihood ratio test in statistical surveillance. Next

There is a common saying in Aotearoa New Zealand: ‘the only good possum is a dead possum’. This colloquialism demonstrates much about the negative reputation and maltreatment of brushtail possums in New Zealand. Introduced to this country from their native Australia in the 1800s, possums thrived in their new predator-free environment. Possums' adaptability has since proved to be problematic, not l

Bolus injections of intravenous propofol and remifentanil can be used in the tracheal intubation of infants and children, but relatively large doses are needed. We hypothesised that addition of a small bolus of rocuronium would ensure good intubation conditions when modest propofol and remifentanil doses were used.

The idea of personal carbon allowances (PCAs) was presented by the UK Environment Secretary, David Miliband, in 2006. Although no nation state is seriously developing proposals for them, they have been discussed within academia, NGOs and policy-making circles. PCAs can be seen as a logical extension of emissions trading schemes, which has so far only applied at the firm level, to individuals. The

We present a review of elemental abundances in the Milky Way stellar disk, bulge, and halo with a focus on data derived from high-resolution stellar spectra. These data are fundamental in disentangling the formation history and subsequent evolution of the Milky Way. Information from such data is still limited and confined to narrowly defined stellar samples. The astrometric Gala satellite will soo