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When oppositely charged polymers and surfactants combine, they can form a concentrated phase rich in micelles interconnected by polymer chains. Dispersing this concentrated phase as nanoparticles in an aqueous media can be a way to load and deliver hydrophobic ingredients. This study employed triblock copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), EOxPOyEOx, also kn

For many severe lung diseases, non-invasive biomarkers from imaging could improve early detection of lung injury or disease onset, establish a diagnosis, or help follow-up disease progression and treatment strategies. Imaging of the thorax and lung is challenging due to its size, respiration movement, transferred cardiac pulsation, vast density range and gravitation sensitivity. However, there is

This explorative study investigates the emergence of gray zone markets from search engines amidst the global expansion of online markets. With the analytical approach of infrastructural inversion, we examine how the search infrastructure constructs access to a gray zone market including both authorized online pharmacies and unauthorized vendors. Using Sweden and Google Search as a case, we explore

Det är hög tid att bryta den osynlighetsprincip som funnits under hela efterkrigstidenrörande de skatter och avgifter som löntagarna betalar. Det skriver nationalekonomernaLars Jonung och Erik Norrman.

Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms underlying the long-term benefits of this short-term treatment remain to be elucidated. Here, we assessed the effects of S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 on myocardial neovascularization in mice with induced MI. The treatment

The lifestyle and consumption patterns of the wealthy exceed our planet's ecological limits. Surprisingly, little experimental research explores the effectiveness of choice architecture interventions targeting the lifestyles and consumption behaviours of the affluent. Addressing this gap, our study investigates the extent to which the top income decile in Sweden can be motivated to take climate ac

Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, with an important role in CRC tumorigenesis, and are either upregulated or downregulated in various cancers. RNA-binding proteins (RBPs) are known as essential regulators of miRNA activity. Human antigen R

Based on a new deep drilling on southern Gotland (Sweden), this study is the first to document the carbon isotope chemostratigraphy of the Upper Ordovician through lowermost Silurian sedimentary record from the central parts of the Baltic Sea subsurface. The lithological record of the Stora Sutarve core has similarities with adjacent successions in both the Viki core in the East Baltic area and th

Aim: The incidence of colorectal cancer (CRC) in Sweden is increasing in individuals <50 years. This study aimed to examine differences in postoperative 30-day complications and rate of emergency surgeries in CRC patients <50 years at diagnosis compared to older age groups since population-based research on this topic is scarce. Method: This population-based study included data from the Swedish Co

Several studies have shown the association between decreased insulin sensitivity and the risk of male hypogonadism. Homeostatic model assessment of insulin resistance (HOMA-IR) is a well-established marker of decreased insulin sensitivity. The triglyceride-glucose index (TyG), calculated as ln fasting triglyceride mg/dL× fasting glucose mg/dL/2, was recently suggested to be a cheaper and a reliabl

Earlier treatment of breast cancer results in better survival. Screening enables this through detection of tumors before they cause symptoms. On the negative side, some tumors if not detected through screening would not cause symptoms, leading to overdiagnosis. Improvements in image quality allow even earlier detection and diagnosis of even smaller tumors at an even earlier stage. This study aims

In this paper we study the numerical quadrature of a stochastic integral, where the temporal regularity of the integrand is measured in the fractional Sobolev-Slobodeckij norm in Wσ,p(0,T), σ ∈(0,2), p∈[2,∞). We introduce two quadrature rules: The first is best suited for the parameter range σ ∈(0,1) and consists of a Riemann-Maruyama approximation on a randomly shifted grid. The second quadrature

For initial value problems associated with operator-valued Riccati differential equations posed in the space of Hilbert–Schmidt operators existence of solutions is studied. An existence result known for algebraic Riccati equations is generalized and used to obtain the existence of a solution to the approximation of the problem via a backward Euler scheme. Weak and strong convergence of the sequenc

Freeze drying is a commonly used method for preserving probiotic bacteria and live biotherapeutic products. Before drying, the bacterial cells are formulated with a lyoprotectant, and the design of these two process steps are crucial to achieve a high-quality product. There are several factors that may affect the biological and physicochemical properties of the freeze-dried cells and we have used

In this paper, we introduce a randomized version of the backward Euler method that is applicable to stiff ordinary differential equations and nonlinear evolution equations with time-irregular coefficients. In the finite-dimensional case, we consider Carathéodory-type functions satisfying a one-sided Lipschitz condition. After investigating the well-posedness and the stability properties of the ran

Differential equations are an important building block for modeling processes in physics, biology, and social sciences. Usually, their exact solution is not known explicitly though. Therefore, numerical schemes to approximate the solution are of great importance. In this thesis, we consider the temporal approximation of nonlinear, nonautonomous evolution equations on a finite time horizon. We pres

Background: Contemporary patients with pulmonary arterial hypertension (PAH) are older and exhibit cardiovascular or/and lung comorbidities. Such patients have typically been excluded from major PAH drug trials. This systematic review compares baseline characteristics, hemodynamic parameters, and mortality rate between PAH patients with significant number of comorbidities compared to those with fe

With more than 260 000 islands, Sweden is one of the countries with most islands in the world. Its islands are located along the coasts and in the larger lakes. For the municipalities and regions where they are located, the islands are places for recreation and symbols in tourism marketing. A rough overview over the impact of the pandemic on rural and remote areas indicates that Swedish tourism in