The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor derived from cells of the sympathetic nervous system, arrested at an immature stage of differentiation.

Since the law of support and service for people with certain disabilities (LSS) was implemented 1994, the carers’ role has changed from «taking care of» to «giving support to» people with intellectual disabilities/autism, but the requirements of knowledge hasn’t been altered. In order to provide appropriate support, carers need both theoretical knowledge and experience of how people with intellect

The use of business excellence models (BEM) has become popular in the last two decades, and several companies have learned how to use them and gained from such models. More companies, we assume, have experienced problems when using such models because of various weaknesses such as too-sophisticated assessment criteria, excessive paperwork, cumbersome procedures and a lack of focus, which have limi

Purpose - The purpose of this paper is to explore what theoretical lenses have been used to analyze and understand information sharing in supply chains. The paper elaborates on the predominant theories and discusses how they can be integrated to research different aspects of information sharing. Design/methodology/approach - The paper carried out a structured literature review by using a combinati

Arctic soils hold large amounts of nutrients in the weatherable minerals and the soil organic matter, which slowly decompose. The decomposition processes release nutrients to the plant-available nutrient pool as well as greenhouse gases to the atmosphere. Changes in climatic conditions, for example, changes in the distribution of snow, water balance and the length of the growing season, are likely

Differences in soil organic matter (SOM) content, soil acidity, and soil exchangeable nutrients (NH4-N, NO3-N, Ca, K, Na, Mg) related to the presence of ground flora were studied. The study was carried out for a growing season in two different Fagus sylvatica L. forests in southern Sweden, and the differences in soil characteristics below naturally occurring patches of Deschampsia flexuosa (L.) Tr

New Winds in Mission Theology: A Comparative Analysis of Three Recent Mission Documents With the Lausanne Movement’s Cape Town Commitment (CTC), World Council of Churches’ Together Towards Life (TTL) and Pope Francis’ Evangelii Gaudium (EG) the three major ecclesiastic families have updated their mission theology. These documents witness for a certain convergence especially through the way in whic

We present here a study of the adsorption of 2-butyne (CH3-C equivalent to C-CH3) on the Si(0 01)-2 x 1 silicon surface at room temperature using synchrotron radiation photoemission spectroscopy (XPS) and X-ray absorption spectroscopy (NEXAFS). In particular, the Si2p and C1s core levels were followed by real-time photoemission (measuring while dosing). The intensity of the Si2p surface state comp

The chapter aims to contribute to an understanding of racism and ethnic discrimination as a tangible experience in the everyday life of immigrants in Poland. The empirical material used are survey questionnaires and in-depth interviews with immigrants from Africa and Asia. The results of this study undermine the reliability of official data, by demonstrating that a large portion of racist crimes c

Assessment of clinical risk factors for haemorrhagic complications in patients undergoing intra-arterial thrombolysis for lower limb ischaemia. Retrospective reviews of consecutive patients subjected to intra-arterial thrombolysis due to lower limb ischemia at the Vascular Center, Malmö University Hospital, during a 5-year period from 2001 to 2005. Two hundred and twenty intra-arterial thrombolyti

This review explores the social causes and psychological and organizational consequences of the criminalization of human error in aviation and healthcare. Increasing prevalence of criminal prosecution is seen as a threat to the health and safety of employees and entire safety-critical systems in many industries, but initiatives to counter or mitigate the trend are local and haphazard. Social cause

Background: The present study protocol describes the trial design of a primary care intervention cohort study, which examines whether an extended, multi-professional physical activity referral (PAR) intervention is more effective in enhancing and maintaining self-reported physical activity than physical activity prescription in usual care. The study targets patients with newly diagnosed hypertensi

Understanding of molecular mechanisms underlying the effects of cell cycle proteins in response to the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to chemotherapeutic agents. Staurosporine and tumor necrosis factor alpha (TNFalpha) are the therapeutic agents that inhibit tumor cell growth by inducing cell death. Staur

Abstract in UndeterminedObjective – To investigate whether Web 2.0 can enhance participation in institutional repositories (IRs) and whether its widespread use can lead to success in this context. Another purpose was to emphasize how an IR with a Web 2.0 approach can connect individuals in their creative and intellectual outputs, no matter what form of shared material is contributed.Design – Compa

Information on the spatial distribution of past vegetation on local, regional and global scales is increasingly used within climate modelling, nature conservancy and archaeology. It is possible to obtain such information from fossil pollen records in lakes and bogs using the landscape reconstruction algorithm (LRA) and its two models, REVEALS and LOVE. These models assume that reliable pollen prod

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Kardiovaskulär sjukdom (CVD) är ett i vårt samhälle växande problem där allt fler insjuknar i akuta hjärtinfarkter, stroke eller hjärtsvikt. Överlevnaden efter insjuknandet har förbättrats med åren med hjälp av nya mediciner och invasiva ingrepp såsom stentning av kranskärlen vid svår kärlkramp och direkt i det akuta skedet vid vissa tThis thesis examines the relationship between measures of renal function and cardiovascular disease (CVD) in patients with hypertension (the NORDIL study) and in the healthy population (Malmö Diet and Cancer Study, MDC) and whether antihypertensive treatment response and the risk of CVD is affected by genetic variation of a regulator of the renal amiloroide sensitive sodium channel (NORDIL). In st

Lepidopteran pheromone receptors (PRs), for which orthologies are evident among closely related species, provide an intriguing example of gene family evolution in terms of how new functions may arise. However, only a limited number of PRs have been functionally characterized so far and thus evolutionary scenarios suffer from elements of speculation. In this study we investigated the turnip moth Ag

Urban development politics are being challenged in various ways today, which becomes obvious when analysing strategies for sustainability versus competitiveness. In parallel to this, alternative ways of fi nancing, planning and organizing urban development and transport projects are becoming more common. However, although the use of publicly owned enterprises in urban development is becoming more