The Wnt signaling pathway is highly conserved and crucial during embryonic development. Aberrant Wnt signaling is important in several different disease processes. One such disease process is the development and progression of cancer. Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. Once a melanoma tumor has spread and formed metastasis, there are few trea

Abstract The last two decades has seen an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). Whether such propensity also exists in arterial circulation is still controversial. The gener

Natural killer (NK) cells represent the third lymphoid lineage playing important role against viral infections and cancer. In contrast to B and T cell development where both cellular and regulatory pathways are well established, the development of NK cells from hematopoietic stem cells (HSCs) is poorly understood. Although bone marrow (BM) represents the main site for postnatal NK cell development

Abstract in UndeterminedIn this paper a VLSI implementation of a highly scalable MMSE (Minimum Mean Square Estimator) is presented with the ultimate goal of demonstrating the potential of MMSE as enabler for multi-standard channel estimation. By selecting an appropriate implementation, a complexity reduction of 98% is achieved when compared to Time-Domain Maximum Likelihood Estimation (TDMLE), whe

Lipid bilayers are of interest in applications where a cell membrane mimicking environment is desired. The performance of the lipid bilayer is largely dependent on the physical and chemical properties of the component lipids. Lipid bilayers consisting of phytanoyl lipids have proven to be appropriate choices since they exhibit high mechanical and chemical stability. In addition, such bilayers have

In this article, Structured Laser Illumination Planar Imaging (SLIPI) is used in combination with the LIF/Mie ratio technique for extracting a reliable two-dimensional mapping of the droplets Sauter Mean Diameter (SMD). We show that even for the case of a fairly dilute spray, where single scattering events are in majority, the conventional LIF/Mie technique still remains largely affected by errors

Objective: to describe the experiences of immigrant parents of an ultrasound examination in the second trimester of pregnancy, highlighting information, communication, thoughts, feelings and well-being. Methods: An exploratory, qualitative study using in-depth interviews with parents separately. Content analysis was used. A total of nine Farsi-speaking couples, in all 18 persons, who now live in S

The ADVEX project involved conducting extensive advection measurements at three sites, each with a different topography. One goal of the project was to measure the [CO2] balance under night-time conditions, in an attempt to improve NEE estimates. Four towers were arranged in a square around a main tower, with the sides of the square about 100 m long. Equipped with 16 sonic anemometers and [CO2] sa

Abstract in UndeterminedIn order to create a successful software product and assure its quality, it is not enough to fulfill the functional requirements, it is also crucial to find the right balance among competing quality requirements (QR). An extended, previously piloted, interview study was performed to identify specific challenges associated with the selection, tradeoff, and management of QR i

As semiconductor technologies enables highly advanced an complex integrated circuits (ICs), there is an increasing need to have more embedded design-for-test (DfT) instruments for test, debug, diagnosis, configuration, monitoring, etc. As these instruments are to be used not only at chip-level but also at board-level and system-level, a key challenge is how to access these instruments from chip te

The existing literature on eco-labeling and green consumerism has been framed within a classical market context where price and quality are the drivers of consumer choice. However, it seems possible that consumers are also concerned about the choices made by other consumers. In fact, it is unclear that people's consumption decisions are made independently of social context. For instance, under the

The structural and optical properties of three different kinds of GaAs nanowires with 100% zinc-blende structure and with an average of 30% and 70% wurtzite are presented. A variety of shorter and longer segments of zinc-blende or wurtzite crystal phases are observed by transmission electron microscopy in the nanowires. Sharp photoluminescence lines are observed with emission energies tuned from 1

Objective. To examine pregnancy outcomes in the partners of male patients with inflammatory joint disease who were or were not exposed to disease-modifying antirheumatic drugs (DMARDs) before conception compared with the outcomes in reference subjects from the general population. Methods. Linkage of data from a longitudinal observational study of patients with inflammatory joint disease (the Norwe

This study examines the influence of vortex core precession on flame flashback of swirl-stabilised hydrogen flames. Theoretical considerations suggest that the angular velocity of a swirling flow is reduced as vortex precession causes it to acquire an eccentric motion around the central axis of the burner. The eccentric motion of the vortex generates a secondary flow, which is thought to reduce th

Currently there is no coherent or sustainable water cooperation among the five states—Israel, Jordan, Lebanon, Palestinian territories and Syria—that share the Jordan River. Why do people not cooperate on sustainable river basin management, even if it seems the most rational course from the perspective of economic benefits? I hypothesize that the political uses of citizenship, identity and securit

Introduction to special edition of Statsvetenskaplig tidskrift (Journal of Political Science) on politics and film.

Presentation av och kommentarer till ett nyupptäckt originalmanuskript (spexmanus) av Axel Wallengren och John Wigforss.

The intensity of a fire is an important factor determining the recovery of soil microorganisms after a forest fire, since it can alter the quality and quantity of carbon sources. Recovery of the microbial community was studied in a Mediterranean pine forest soil subjected to different temperatures to simulate the short-term effects of fire intensity on bacterial and fungal growth, estimated using

It is frequently observed that the local relative abundances of aquatic microbial taxa are correlated with their average relative abundance at the regional scale, which results in the composition of different communities being more similar than expected by chance or invariant. The degree to which communities within a region match the regional average community is variable and likely depends on sev