Within a broader definition of design, as the conception and planning of everything that is artificial, the place of tools is central. With the help of cognitive semiotics in general and Donald’s theory of the evolution of the human mind in particular, we propose a stage model for the evolution of design, consisting of four stages: Proto-design, Simple design, Complex design, and Advanced design,

Abstract in Spanish:El estudio de la relación entre la cultura material y el lenguaje tiene una larga tradición, desde los avances en el campo de la evolución de la cultura hasta los hallazgos de las ciencias cognitivas. Las recientes conclusiones de estos estudios se inclinan por la diversidad lingüística y la lingüística evolutiva desestimando el rol de los universales. Este artículo explora el The study of the relationship between material culture and language has a long tradition, from the studies of cultural evolution to the findings of the cognitive sciences. The recent conclusions of these studies in relation to the universals of language tend towards linguistic diversity and evolutionary linguistics, neglecting the role of universals. This article explores the role of artifacts in

Breath-hold divers (BHD) enduring apnea for more than 4 min are characterized by resistance to release of reactive oxygen species, reduced sensitivity to hypoxia, and low mitochondrial oxygen consumption in their skeletal muscles similar to northern elephant seals. The muscles and myocardium of harbor seals also exhibit metabolic adaptations including increased cardiac lactate-dehydrogenase-activi

Background: We studied the association between cardiorenal function and survival, neurological outcome and trends in survival after in-hospital cardiac arrest (IHCA). Methods: We included cases aged ≥ 18 years in the Swedish Cardiopulmonary Resuscitation Registry during 2008 to 2020. The CKD-EPI equation was used to calculate estimated glomerular filtration rate (eGFR). A history of heart failure

Objective: To evaluate asynchronous digital visits (eVisits) with regard to digital communication, clinical decisionmaking,and subsequent care utilization in the digital era of primary care in Sweden.Methods: A mixed-methods approach was adopted across the various papers in the thesis, with all studiesevaluating the eVisit platform Flow in various clinical contexts.- Paper I was a comparative stud

Background: Herbivores modify the structure and function of tundra ecosystems. Understanding their impacts is necessary to assess the responses of these ecosystems to ongoing environmental changes. However, the effects of herbivores on plants and ecosystem structure and function vary across the Arctic. Strong spatial variation in herbivore effects implies that the results of individual studies on

A search is performed for a long-lived particle decaying into a final state that includes a pair of muons of opposite-sign electric charge, using proton-proton collision data collected at s=13 TeV by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 32.9 fb-1. No significant excess over the Standard Model expectation is observed. Limits at 95% confidence

How will higher education and research evolve in the future to produce the high-level knowledge and skilled human capital which underpin sustainable societies?This book explores challenges for the post-knowledge society and economy where major socio-economic change is occurring in tandem with advances in digital technologies. It brings together international authors to discuss scenarios against a

COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19-related

Historically, aerosols of anthropogenic origin have offset some of the warming from increased atmospheric greenhouse gas concentrations. The strength of this negative aerosol forcing, however, is highly uncertain-especially the part originating from cloud-aerosol interactions. An important part of this uncertainty originates from our lack of knowledge about pre-industrial aerosols and how many of

Dealing with structural breaks is an essential step in most empirical economic research. This is particularly true in panel data comprised of many cross-sectional units, which are all affected by major events. The COVID-19 pandemic has affected most sectors of the global economy; however, its impact on stock markets is still unclear. Most markets seem to have recovered while the pandemic is ongoin