Dopamine replacement for Parkinson's disease (PD) have seen three major iterations of improvements since the introduction of l-3,4-dihydroxyphenylalanine (l-DOPA) pharmacotherapy: dopamine receptor agonists, ex vivo gene transfer for cell transplantation and most recently in vivo gene therapy. In this chapter, we describe the principles behind viral vector-mediated enzyme replacement in PD. We foc

Background Family history is a strong risk factor for prostate cancer. The aim of this study was to investigate whether increased diagnostic activity is related to the incidence of prostate cancer among brothers of men with prostate cancer. Methods Data were from the nationwide population-based Prostate Cancer Database Sweden (PCBaSe Sweden), which includes data from the National Prostate Cancer R

Interstitial laser thermotherapy was used to treat rat liver tumours. The aim was to investigate the influence of temperature and temporary hepatic inflow occlusion on tumour growth and blood perfusion.

Life-space mobility refers to the spatial area in which a person moves in daily life, taking into account distance, frequency and assistance needed. The aim was to examine how changes in life-space mobility are associated with changes in quality of life (QOL) over a 2-year period.

Om hotet om kärnvapenkrig under kalla kriget i amerikanska spelfilmer.

Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to mod

Two novel sites of autophosphorylation were localized to the juxtamembrane segment of the human platelet-derived growth factor (PDGF) beta-receptor. To evaluate the importance of these phosphorylation sites, receptor mutants were made in which Tyr579, Tyr581 or both were replaced with phenylalanine residues; the receptor mutants were stably expressed in porcine aortic endothelial cells. Compared w

Recension av två böcker om sex-, skräck och actionfilm - Ekeroths med fokus på svenska titlar från 1960-talet och framåt, Blomdahls med fokus på både europeisk och amerikansk skräck från 1980 och framåt.

Under lång tid har såväl studenter som lärare inom humaniora önskat och krävt mer lärarledd undervisningstid. I väntan på det vill jag emellertid diskutera hur man som lärare kan hjälpa studenterna att utnyttja självstudietiden på ett så effektivt sätt som möjligt med ett minimum av lärarresurser, för att på så sätt öka kontakttiden med ämnet. Diskussionen tar sin utgångspunkt i pedagogisk forskni

To achieve their business objectives, software developing companies employ different technical and managerial strategies concerning architecture and reuse. These strategies include component-based development, software platforms, product lines and highly configurable code bases. Frameworks for describing these strategies have recently emerged, presenting them in orders of increasing maturity, with

This thesis is comprised of five papers that are all related to the subject of financial time series. We study statistical aspects of conditional heteroskedastic models commonly used in modelling financial volatility. Paper I discusses the performance of commonly known information criteria in the presence of various GARCH processes. The investigation has been performed using Monte Carlo simulatio

In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of dat