Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR

Electron correlation and multielectron effects are fundamental interactions that govern many physical and chemical processes in atomic, molecular and solid state systems. The process of autoionization, induced by resonant excitation of electrons into discrete states present in the spectral continuum of atomic and molecular targets, is mediated by electron correlation. Here we investigate the attos

Resected hippocampal tissue from patients with drug-resistant epilepsy presents a unique possibility to test novel treatment strategies directly in target tissue. The post-resection time for testing and analysis however is normally limited. Acute tissue slices allow for electrophysiological recordings typically up to 12 hours. To enable longer time to test novel treatment strategies such as, e.g.,

In this study, electrospinning has been employed to produce micro to nano scale fibres of whey protein in order to investigate their potential for use in the food industry. Initially, spinning of pure whey protein proved challenging; so in order to facilitate the spinning of freshly prepared aqueous solutions, small amounts of polyethylene oxide (as low as 1% w/w in solution) were incorporated in

Advances in sequencing technologies led to rapid increase in the number and diversity of biological sequences, which facilitated development in the sequence research. In this paper, we present a new method for analyzing protein sequence similarity. We calculated the spectral radii of 20 amino acids (AAs) and put forward a novel 2-D graphical representation of protein sequences. To characterize pro

This article takes stock of the world's largest low-carbon technology demonstration programme – the EU's NER 300. The programme has been marked by delays and many withdrawn projects since becoming operational in 2010: CCS projects have failed and not reached final investment decisions; wind and solar projects have succeeded, whereas bioenergy projects have seen successes as well as failures. These

Denna avhandling syftar till att utöka kunskapsbasen om hur grundskolelärare i Sverige kommunicerar och interagerar i sitt yrke och vilka arbetsrelaterade hälsoproblem de upplever. Avhandlingen bygger på två studier, vilka genererat tre artiklar. Papper I är baserat på resultat från en explorativ studie med fokusgruppsmetodik. I denna studie undersöktes arbetsplatskommunikationspraxis bland skolläDuring recent years, schoolteachers in Sweden have experienced many reforms and societal changes, resulting in altered conditions for work. Subsequently, many teachers have reported an increased workload and reduced well-being. In addition, previous research has identified a need for more contextually anchored measures of demands and resources pertaining to teachers’ work situation.This dissertati

While health might deteriorate through the ageing and disablement process, the impacts of disability can be reduced by adapting the environment. This study aimed to investigate the effects of applying a standardized research-based strategy to housing adaptation as compared to ordinary practice with respect to falls and fear of falling. Another aim was to investigate the overall effects of housing

Purpose: An unprecedented scale of human migration has lead humanitarians to view camps as long-term settlements rather than temporary holding facilities. The purpose of this paper is to increase the understanding of and identify challenges with this proposed new approach to camp design. Design/methodology/approach: Based on the camp design literature, the authors developed an interview guide and

Two new genera in the subfamily Teloschistoideae (Teloschistaceae, Teloschistales) are described: Hosseusiella S. Y. Kondr., L. Lőkös et A. Thell for the Caloplaca chilensis group including three South American species and Rehmanniella S. Y. Kondr. et J.-S. Hur for the new species, R. wirthii S. Y. Kondr. from South Africa. The new genera are supported by a three-gene phylogeny based on ITS1/ITS2

Nineteen new to science species of lichen forming fungi, i.e.: Agonimia ascendens S. Y. Kondr., L. Lőkös et J.-S. Hur, A. sunchonensis S. Y. Kondr. et J.-S. Hur, A. yongsangensis S. Y. Kondr. et J.-S. Hur, Biatora loekoesiana S. Y. Kondr. et J.-S. Hur, Caloplaca ivanpisutii S. Y. Kond., L. Lőkös et J.-S. Hur, Candelariella makarevichiae S. Y. Kondr., L. Lőkös et J.-S. Hur, Huriella pohangensis S.

Climate change, increasingly recognized as a hurdle to achieving sustainable development goals, has already begun impacting the lives and livelihoods of people around the world, including on the African continent. Vulnerability is a concept often employed in the context of climate change to identify risks and develop policy and adaptation measures that address current and projected impacts. Howeve

This paper examines a digital employee-oriented innovation program at a global IT-firm. It addresses the research question: how is the generation and promotion of employee ideas organised by the management, and what are the behavioural implications in terms of participation of such an organising? Drawing on the literature on inclusive innovation and employee-driven innovation, the authors explore

We consider adaptive time discretization methods for ordinary differential equations where one aims to control the error in a quantity of interest of the form J(u) = ∫ j(u(t))dt with j : Rd -> R. In this setting we propose a new timestep controller based on local error estimates of the quantity of interest. The new method converges when the tolerance goes to zero.We experimentally compare the new

The body – or, more specifically, women’s bodies – has long been one of feminism’s central topics. This discussion has ranged from explorations of the cultural meaning of biology to the challenging of classification systems regulating bodies not only culturally coded as female or male but also understood through race regimes. This article seeks to explore the location of bodies within Swedish femi

Using exceptionally rich qualitative data coming from the FP7 EUCROSS project on the ‘Europeanization of the Everyday Life’, this paper focuses on high-skilled and highly transnational Turkish migrants who reside in the UK, Romania and Italy. The article analyses participants’ discursive constructions of Europe and Europeanness and shows how specific images and symbols of Europe and Turkey influen

The Komstad Limestone forms a distal part of the widespread ‘orthoceratite limestone’ of the Baltoscandian continent. In this paper, we present an integrated conodont biostratigraphy and carbon isotope stratigraphy for a major part of this formation and address its significance for evaluating Middle Ordovician correlation and overall stratigraphy. Four conodont zones are distinguished, including t