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Leukocyte adhesion in aorta and femoral artery in vivo is mediated by LFA-1

Objective: Cytokine-induced recruitment of leukocytes is an early feature during arterial injury and atherosclerotic plaque formation. The aim of this study was to analyze the role of the beta(2)-integrin lymphocyte function-associated antigen-1 (LFA- 1; CD11a/CD18) in cytokine-triggered firm leukocyte adhesion to arterial endothelium in vivo. Material and Methods: Intravital fluorescence microsco

Short-range structure of proton-conducting perovskite BaInxZr1-xO3-x/2 (x=0-0.75)

In a systematic study, we investigate the effect of dopant level and hydration on the short-range structure of the proton-conducting perovskite-type oxide BaInxZr1-xO3-x/2 (x = 0 - 0.75), using infrared and Raman spectroscopy. The results show that the doping leads to significant local distortions of the average cubic structure of these materials. By increasing the In concentration from x = 0 to x

Outline of a convergence proof for compact difference methods applied to nonlinear initial-boundary value problems.

An initial-boundary value problem to a system of nonlinear partial differential equations, which consists of a hyperbolic and a parabolic part, is taken into consideration. The problem is discretised by a compact finite difference method. An approximation of the numerical solution is constructed, at which the difference scheme is linearised. Nonlinear convergence is proved using the stability of t

Long- and short-term state-dependent foraging under predation risk: an indication of habitat quality

Animals living in environments of different quality will have different expectations of their future reproductive success and survival. This may affect the individual's risk-taking behaviour as manifest in the cost of predation. We investigated the foraging behaviour of starlings, Sturnus vulgaris, when perceived predation risk varied between patches. Short-term food availability varied between tr

Contemporary evolution of secondary sexual traits in the wild

1. Sexual selection has been studied intensively, and is often strong in natural populations. Theoretical models, comparative studies and laboratory selection experiments all suggest that evolution driven by sexual selection should be rapid and common. 2. However, there are relatively few documented cases of the contemporary evolution of secondary sexual traits in natural populations. Moreover, th

Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential.

Two novel vanadium complexes, [V(IV)O(bp-O)(HSO4)] (1) and [V(IV)O(bp-OH)Cl2] x CH3OH (2 x CH3OH), where bp-OH is 2-{[bis(pyrid-2-yl)methyl]amine}methylphenol, were prepared and structurally characterised. EPR spectra of methanol solutions of 2 suggest exchange of Cl- for CH3OH and partial conversion to [VO(bp-OH)(CH3OH)3]2+. Speciation studies on the VO2+-bpOH system in a water/dmso mixture (4:1

Ionic Conductivity and Dielectric Properties of Poly(ethylene oxide) Graft Copolymers End-capped with Sulfonic Acid

Both anions and cations are mobile and carry the electrical charge in most polymer electrolytes. A single ion conductor with purely cationic conduction can be realized by incorporation of the anion into the polymer chain. In order to obtain pure lithium ion conductors we prepared two types of graft copolymers, namely poly(amide 12-graft-ethylene oxide) and poly(ethylene-co-vinyl alcohol-gr aft-eth

Decreased monoamine metabolites in frontotemporal dementia and Alzheimer's disease

The concentrations of the monoamine metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (HMPG) in the cerebrospinal fluid (CSF) of patients with clinical frontotemporal dementia (FTD; n = 30), early onset Alzheimer's disease (EAD; n = 33), late onset Alzheimer's disease (LAD, n = 27) and normal controls (n = 31) were determined using HPLC. A

Will Swedish Biomass be Sufficient for Future Transportation Fuel Demands?

There is a potential to increase the annual use of biomass in Sweden by 125 TWh between 1994 and 2015. 125 TWh of biomass would satisfy most of the transportation-fuel demand in Sweden in 2015. Even if the biomass is primarily used for heat and electricity production, a significant fraction will be available for transportation-fuel production, if other non-fossil energy sources are utilized for el

Neutrophil elastase sorting involves plasma membrane trafficking requiring the C-terminal propeptide.

The primary granules/secretory lysosomes of neutrophils store mature neutrophil elastase (NE) as a luminal protein after proteolytic removal of N-terminal and C-terminal pro-peptides from a proform of NE. The N-terminal pro-peptide prevents premature activation that might be toxic to the cell, but the C-terminal pro-peptide has no defined function. In this study, we investigated the role of the C-

Defective paracrine signalling by TGF beta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder in humans that is characterised by multisystemic vascular dyplasia and recurrent haemorrhage. Germline mutations in one of two different genes, endoglin or ALK1 can cause HHT. Both are members of the transforming growth factor (TGF) beta receptor family of proteins, and are expressed primarily on the surface of endothel

The vasorelaxant effect of adrenomedullin, proadrenomedullin N-terminal 20 peptide and amylin in human skin

In this study we aimed to assess in vivo, the vasodilator effects of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and amylin in human skin vasculature and compare the responses to the effects mediated by the endogenenous neuropeptides calcitonin gene-related peptide (CGRP) and substance P and to examine the mRNA expression of calcitonin receptor-like receptor (CL-R) and receptor-

Densities and viscosities of mono(ethylene glycol) plus 2-amino-2-methyl-1-propanol plus Water

The densities and viscosities of ternary mixtures of mono(ethylene glycol) (MEG) + 2-amino-2-methyl-1-propanol (AMP) + water have been measured at temperatures of 25 to 40 degreesC. The water content varied in the range 1.4 to 15.6 mol %, and the amine concentration varied from 0 to 11.8 mol %. The excess volumes were calculated from the experimental data and fitted to a simple Redlich-Kister type