Background. Tissue transglutaminase (tTG) autoantibodies are serological markers for celiac disease. The aim was to study the efficacy of the pTnT-rhtTG plasmid and subsequent diagnostic accuracy of tTG autoantibodies for childhood celiac disease using radioligand binding assays. Methods. Coupled in vitro transcription and translation of tTG were performed by pTnT-rhtTG as well as by the pGEMt Eas

Thrombotic microangiopathy is the pathological lesion found in hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP) as well as other conditions. It manifests as damaged endothelial cells in small vessels with deposits of platelet plugs, occlusion of vessels, decreased blood flow and secondary organ insufficiency. HUS is characterized by microangiopathic hemolytic anemia, thro

OBJECTIVE: To investigate resource consumption and quality of life (utility) in a sample of patients covering the full spectrum of the disease, modalities of patient management and geographic areas. METHODS: Information on demographics, disease parameters, work capacity and resource consumption (in the past 1, 3 or 12months depending on the resource) was collected in an anonymous mail survey from

BACKGROUND: Antiplatelet reagents have been reported to protect against intestinal damage associated with abdominal radiotherapy, but the mechanisms behind radiation-induced platelet-endothelium interactions are not known. We sought to define the adhesive mechanisms that regulate radiotherapy-induced platelet-endothelial cell interactions in the colon. METHODS: All mice except the controls were ex

Kulturartikel om rysaren och spökfilmens återkomst i skräckgenren efter decennier av bloddrypande och våldsam slasherfilmer.

Svar på ledarartikel som hade angripit rapport om enkätundersökning utförd vid lokala sociala forum.

BACKGROUND: The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of

Popular Abstract in Swedish Olika morfologiska former i olika språk antas bero på gemensamma kognitiva funktioner och semantiska egenskaper. En övergripande term för sådana semantiska egenskaper är transitivitet. Transitivitet yttrar sig bl.a. i aspekt hos verbet och bestämdhet hos objektet. En avgörande kognitiv funktion är för- och bakgrundsstruktur av information. Detta testas här empiriskt i (This work assumes that various linguistic forms in different languages are related to common cognitive functions and semantic properties. A cognitive function - presumably universal - is information transmission. The notion of interest is transitivity, which contains a set of semantic properties such as agentivity, dynamism, affectedness, boundedness and givenness, and the explicit forms are verb

FYN is a non-receptor tyrosine kinase belonging to the SRC family of kinases, which are frequently over-expressed in human cancers, and play key roles in cancer biology. SRC has long been recognized as an important oncogene, but little attention has been given to its other family members. In this report, we have studied the role of FYN in FLT3 signaling in respect to acute myeloid leukemia (AML).