Bakgrund: I Sverige överlever åttiofem procent av alla barn under femton år sin cancersjukdom. Utvecklingen av medicinsk teknik och behandlingar har bidragit till att allt fler barn överlever sjukdomen. Upplevelsen av barncancervård är väl utforskat utifrån föräldrars upplevelser, men studier om barns egna upplevelser är svårare att hitta. Genom att sammanställa de studier som undersöker barns upp

Some microorganisms, like the aerobic soil bacteria, Oligotropha carboxidovorans, have the capability to oxidize the highly toxic atmospheric gas carbon monoxide (CO) into CO2 through CO dehydrogenase enzymes, whose active site contains a bimetallic MoCu center. Over the last decades, a number of experimental and theoretical investigations were devoted to understanding the mechanism of CO oxidatio

AbstractBackground We aimed to evaluate if optimization by maximizing QRS duration (QRSd) reduction is feasible in an all-comercardiac resynchronization therapy (CRT) population, and if reduced, QRSd is associated with a better clinical outcome.Methods Patients with LBBB receiving CRT implants during the period 2015–2020 were retrospectively evaluated. Implantsfrom 2015–2017 were designated as conBackgroundWe aimed to evaluate if optimization by maximizing QRS duration (QRSd) reduction is feasible in an all-comer cardiac resynchronization therapy (CRT) population, and if reduced, QRSd is associated with a better clinical outcome.MethodsPatients with LBBB receiving CRT implants during the period 2015–2020 were retrospectively evaluated. Implants from 2015–2017 were designated as controls. S

People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with cardiovascular outcomes. We assessed suPAR’s pathogenic involvement in atherosclerosis using epidemiologic, genetic, and experimental approaches. We f

ObjectiveMepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported studies, successful real-life experiences with the approved dose for treating severe eosinophilic asthma (100 mg every 4 weeks) were observed. We undertook this study to assess the

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliable methods to reconstruct evolutionary trajectories of mutational signature activity. Here, as part o

INTRODUCTION: BAY 81-8973, a full-length recombinant factor VIII for hemophilia A treatment, has been extensively evaluated in previously treated patients in the LEOPOLD (Long-Term Efficacy Open-Label Program in Severe Hemophilia A Disease) clinical trials.AIM: To assess BAY 81-8973 efficacy and safety when used for bleed prophylaxis and treatment in previously untreated/minimally treated patients

Intrinsic polarization-sensitive photodetectors (IPPDs) have attracted considerable attention in recent years due to their simplicity in configuration, making them ideal candidates for compact and integrated polarization-sensitive sensing and imaging systems. Photoactive films with intrinsic optical anisotropy are necessary for IPPDs. This study reports an achievement of photoactive films based on

Recent industrial interest in producing smaller volumes of products in shorter time frames, in contrast to mass production in previous decades, motivated the introduction of human–robot collaboration (HRC) in industrial settings, as an attempt to increase flexibility in manufacturing applications by incorporating human intelligence and dexterity to these processes. This thesis presents methods for

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

The Cherenkov Telescope Array (CTA), conceived as an array of tens of imaging atmospheric Cherenkov telescopes (IACTs), is an international project for a next-generation ground-based gamma-ray observatory, aiming to improve on the sensitivity of current-generation instruments a factor of five to ten and provide energy coverage from 20 GeV to more than 300 TeV. Arrays of IACTs probe the very-high-e

Metal closo-boranes have recently received significant attention as solid-state electrolytes due to their high thermal and electrochemical stability, and the weak interaction between the cat- and anion, facilitating fast ionic conductivity. Here we report a synthesis method for obtaining a novel mixed closo-carborane compound, [NH(CH3)3][(CB8H9)0.26(CB9H10)0.66(CB11H12)0.08]. The crystal structure

The purpose of this thesis is to identify the problems and challenges that the County Administrative Boards (CAB) perceive when conducting risk- and vulnerability assessments (RVA) and to identify which problems and challenges the new structural reform can cause. Two methods have been utilized – a literature study, and an interview study involving a total of 11 CABs. The thesis shows that implemen

The relative importance of adaptation and individual ontogenetic experience in dogs’ high levels of behavioral compatibility with humans has been a topic of intense scientific attention over the past two decades. Salomons et al. Current Biology, 31, 3137–3144, (2021) recently presented a particularly rich data set of observations on both wolf and dog puppies that has the potential to contribute su

We investigate the possibility of detection of the VHE gamma-ray counterparts to the neutrino astrophysical sources within the Neutrino Target of Opportunity (NToO) program of CTA using the populations simulated by the FIRESONG software to resemble the diffuse astrophysical neutrino flux measured by IceCube. We derive the detection probability for different zenith angles and geomagnetic field conf

The various existing measures to quantify upper limb use from wrist-worn inertial measurement units can be grouped into three categories: 1) Thresholded activity counting, 2) Gross movement score and 3) machine learning. However, there is currently no direct comparison of all these measures on a single dataset. While machine learning is a promising approach to detecting upper limb use, there is cu