Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cell

Surrogate measures of safety (SMoS) are meant to be an alternative/complement to crash data that enables a proactive approach to traffic safety. Validity is a fundamental property of SMoS that describes how well they reflect the quality of interest – traffic safety. However, typical validation studies are extremely resource demanding. Therefore, the aim of this study was to explore a relative appr

The realization of unique scientific phenomena in two-dimensional nanomaterials (2DNMs) has led to their applications in several electronic fields; making it imperative to understand the conduction mechanism of charge carriers in such systems. Though several studies have been conducted on 2DNMs with pristine crystallinity, the inevitable presence of defects in the crystals requires careful conside

Museomics is a valuable approach that utilizes the diverse biobanks that are natural history museums. The ability to sequence genomes from old specimens has expanded not only the variety of interesting taxa available to study but also the scope of questions that can be investigated in order to further knowledge about biodiversity. Here, we present whole genome sequencing results from the enigmatic

Major volcanic eruptions are one of the most devastating and unpredictable events for all societies past and present. Althoughmajor progress has been made by archaeologists in understanding volcanic impacts on past societies, almost all this work hasfocused on urban or settled agricultural societies. In contrast, there is a major gap in knowledge about how forager communitieswere able to respond a

PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti

Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) occur frequently as comorbid diagnoses among adolescents. Historically, these conditions have been treated using a sequential model; however, emerging evidence suggests that an integrated treatment model may be most effective. This article presents two de-identified clinical case studies from an ongoing randomised controlled tr

The performance of the ATLAS Inner Detector alignment has been studied using pp collision data at s=13TeV collected by the ATLAS experiment during Run 2 (2015–2018) of the Large Hadron Collider (LHC). The goal of the detector alignment is to determine the detector geometry as accurately as possible and correct for time-dependent movements. The Inner Detector alignment is based on the minimization

In magnetomotive ultrasound imaging, the tissue displacement due to a magnetic force on embedded magnetic nanoparticles is measured. It was previously shown that the nanoparticle contrast agent exhibits a non-linear magnetization characteristic, which is also reflected in the magnetomotive force. However, this non-linearity was rarely taken into account for the application. Here, the implications

Abstract SummaryIn the late 1920s, Åke Gustafsson and Herman Nilsson-Ehle started experiments of induced mutations at the Svalöf Plant Breeding Station in Sweden. Already in the mid-1930s, the first viable mutations appeared, and in 1940 an extended research program was set up. Gustafsson devoted much of his scientific career to mutation research. With funding granted by the Swedish government, he

Microvesicles are shed from cell surfaces during infectious or inflammatory conditions and may contribute to the pathogenesis of disease. During Shiga toxin-producing Escherichia coli (STEC) infection, microvesicles are released from blood cells. These microvesicles play a part in inflammation, thrombosis, hemolysis, and the transfer of the main virulence factor of STEC strains, Shiga toxin, to ta

Det är på tiden att västvärlden och Sverige tar sin hand ifrån den egyptiske diktatorn, Mubarak, och stödjer det egyptiska folket i sin strävan mot demokrati och mänskliga rättigheter.

This study evaluated the role of endogenous and exogenous annexin A1 (AnxA1) in the activation of the NLRP3 inflammasome in isolated peritoneal neutrophils. C57BL/6 wild-type (WT) and AnxA1 knockout mice (AnxA1-/-) received 0.3% carrageenan intraperitoneally and, after 3 h, the peritoneal exudate was collected. WT and AnxA1-/- neutrophils were then stimulated with lipopolysaccharide, followed by t

Metolachlor is a selective pre-emergent herbicide widely used in agriculture to control weeds. The aim of this study was to evaluate the possible effects of metolachlor on reproductive performance of adult rats, as well as its teratogenic potential when administered during the period of organogenesis. Pregnant adult female rats were allocated into 4 experimental groups (n = 10 group-1), that recei