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Quality of Life in Patients with High-grade Non–muscle-invasive Bladder Cancer Undergoing Standard Versus Reduced Frequency of Bacillus Calmette-Guérin Instillations : The EAU-RF NIMBUS Trial

Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non–muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatmen

Innovations, informality, and the global south : A thematic analysis of past research and future directions

The informal sector of the global south has lately started to gain attention from innovation and development studies scholars. Studies highlighting the determinants, barriers, social processes, and institutions that influence innovations in the informal sector have enriched the discussion on the topic. This paper analyzes the existing body of knowledge at the intersection of the informal sector, i

A highly-detailed anatomical study of left atrial auricle as revealed by in-vivo computed tomography

The left atrial auricle (LAA) is the main source of intracardiac thrombi, which contribute significantly to the total number of stroke cases. It is also considered a major site of origin for atrial fibrillation in patients undergoing ablation procedures. The LAA is known to have a high degree of morphological variability, with shape and structure identified as important contributors to thrombus fo

Charles Bonnet Syndrome Adversely Affects Vision-Related Quality of Life in Patients with Glaucoma

Purpose: To investigate the impact of Charles Bonnet syndrome (CBS) on vision-related quality of life (VRQoL) in patients with glaucoma. Design: Cross-sectional cohort study. Participants: Twenty-four patients with CBS and 42 matched controls without CBS out of 337 patients with open-angle glaucoma (OAG) with visual field (VF) loss. Methods: A matching technique was used to identify control patien

Expression of the chemokine decoy receptor D6 is decreased in colon adenocarcinomas

Recruitment of immune cells to tumors is a complex process crucial for both inflammation-driven tumor progression and specific anti-tumor cytotoxicity. Chemokines control the directed migration of immune cells, and their actions are partly controlled by nonsignaling chemokine decoy receptors. The role of the receptors such as D6, Duffy antigen receptor for chemokines and ChemoCentryx chemokine rec

Class-switch recombination to IgA in the Peyer’s patches requires natural thymus-derived Tregs and appears to be antigen independent

Our understanding of how class-switch recombination (CSR) to IgA occurs in the gut is still incomplete. Earlier studies have indicated that Tregs are important for IgA CSR and these cells were thought to transform into follicular helper T cells (Tfh), responsible for germinal center formation in the Peyer’s patches (PP). Following adoptive transfer of T-cell receptor-transgenic (TCR-Tg) CD4 T cell

Detection of wind turbines rotary motion by birds : A matter of speed and contrast

To reduce bird collisions on wind turbines, Automatic Detection Systems have been developed to locate approaching birds and trigger turbines to slowdown to 2–3 rotations per minute (rpm). However, it is unknown whether birds can detect this reduced speed and avoid the turbine. We conducted an operant conditioning experiment on domestic doves (Streptopelia roseogrisea) and Harris's hawks (Parabuteo

Coherence Estimation Tracks Auditory Attention in Listeners with Hearing Impairment

Coherence estimation between speech envelope and electroencephalography (EEG) is a proven method in neural speech tracking. This paper proposes an improved coherence estimation algorithm which utilises phase sensitive multitaper cross-spectral estimation. Estimated EEG coherence differences between attended and ignored speech envelopes for a hearing impaired (HI) population are evaluated and compa

Your Language Escapes Me! : Multimodality of a Migrant Life

This chapter looks at three different cases, which extend from literature to protest, to examine the multimodality of translation and translanguaging in intercultural communication. The cases include excerpts from the novel On Earth We Are Briefly Gorgeous, the graphic novel Persepolis and practices of lip-sewing among refugees, as documented in online media. They represent different communicative

Determination of blood cell subtype concentrations from frozen whole blood samples using TruCount beads

Background: In many studies it would be advantageous if blood samples could be collected and analyzed using flow cytometry at a later stage. Ideally, sample collection should involve little hands-on time, allow for long-term storage, and minimally influence the samples. Methods: Here we establish a flow cytometry antibody panel that can be used to determine granulocytes, monocytes, and lymphocyte

Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1

Severe Plasmodium falciparum malaria infections are caused by microvascular sequestration of parasites binding to the human endothelial protein C receptor (EPCR) via the multi-domain P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion ligands. Using cryogenic electron microscopy (Cryo-EM) and PfEMP1 sequence diversity analysis, we found that group A PfEMP1 CIDRα1 domains interact with t

Effect of Different In2O3(111) Surface Terminations on CO2 Adsorption

In2O3-based catalysts have shown high activity and selectivity for CO2 hydrogenation to methanol; however, the origin of the high performance of In2O3 is still unclear. To elucidate the initial steps of CO2 hydrogenation over In2O3, we have combined X-ray photoelectron spectroscopy and density functional theory calculations to study the adsorption of CO2 on the In2O3(111) crystalline surface with

Sollentuna Boulevard

This work focuses on the southern part of Sollentuna municipality and the adjacent suburbs of Kista, Husby and Akalla located in the northernmost part of Stockholm municipality, which henceforth will be referred to as “Kista”. The urban core of Sollentuna/Kista is strategically located both close to Stockholm but also along the north going road towards both Arlanda airport and Swedens fourth city

Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation

Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) discontinuation. To study this, we analyzed 55 single-cell RNA and T cell receptor (TCR) sequenced samples (scRNA+TCRαβ-seq) from patients with CML (n = 13, N = 25), other cancers (n = 28), and he

How do people aggregate value? An experiment with relative importance of criteria and relative goodness of alternatives as inputs

The concept of importance of criteria is used as a central element in several decision making contexts, specifically in value aggregation, e.g. as an input to decision support tools. For example, in the analytic hierarchy process (AHP) decision makers are asked to estimate how much more important one criterion is than another. However, it is not clear how people understand aggregation models based

Vocal communication : The enigmatic production of low-frequency purrs in cats

Cat purring, the unusual, pulsed vibration that epitomizes comfort, enjoys a special status in the world of vocal communication research. Indeed, it has long been flagged as a rare exception to the dominant theory of voice production in mammals. A new study presents histological and biomechanical evidence that purring can occur passively, without needing muscle vibration in the larynx controlled b

A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27-IgMhigh B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation

The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27+ B cells formed after transplantation with the number of CD27+IgMhigh cells more affected than class-switched ones. A previously unacknowledged population of CD27-IgMhigh cells made up the majority of