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Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells

OBJECTIVE: The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle cells.MATERIALS AND METHODS: Cellular import of LL-37 and synthetic dsRNA (poly I:C) were investigated by immunocytochemistry and fluorescence imaging. Transcript and protein express

Rural Income Diversification, Employment, and Differentiation in Kenya and Implications for Rural Change

To contribute to contemporary rural development debates, the present thesis conducts a contextual analysis of rural development using Kenya as a case study from the colonial era to today. To perform the analysis, two critical trends in rural Africa are focused on: socioeconomic differentiation and rural income diversification, with a particular focus on large-scale farm employment. By pointing to

Isolated photon production and pion-photon correlations in high-energy pp and pA collisions

A phenomenological study of the isolated photon production in high energy pp and pA collisions at RHIC and LHC energies is performed. Using the color dipole approach we investigate the production cross section differential in the transverse momentum of the photon considering three different phenomenological models for the universal dipole cross section. We also present the predictions for the rapi

Exploring and improving industry-academia communication in software engineering

Background: Despite the mutual benefit of the industry-academia partnership, the level of joint work is still low. For this reason, the interest in connecting research and practice has increased recently in the academic community. Objective: This research aims to design and apply approaches to improve the knowledge exchange between academic researchers and software engineering practitioners. Metho