The KEYNOTE-564 trial showed that adjuvant immune checkpoint inhibitor (ICI) therapy with pembrolizumab, a PD-1 antibody, significantly improved disease-free survival (DFS) and overall (OS) survival in localised clear-cell renal cell carcinoma (RCC) with a high risk of relapse. The TiNivo and CONTACT-03 trials have reported results for subsequent therapy after progression on ICI therapy in the met

Achieving good acoustic particle or cell separation performance requires skilled operators, who must carefully fine-tune the input parameters (actuation voltages, flow rates, and flow split ratios). Often the fine-tuning is done by time-consuming parameter sweeps, which are tedious and expensive. Here, we present a straightforward model-based approach to determining input parameters that yield opt

Varje cell i kroppen bär på drygt tjugotusen gener som ärvs från föräldrarna och som fungerar som instruktioner för att producera kroppens olika proteiner. Gener har en bestämd sekvens för att deras protein ska uppfylla rätt funktion men när cellerna delar på sig eller utsätts för yttre faktorer såsom strålning eller giftiga kemikalier kan en mutation uppstå. Det felaktiga proteinet kan ge upphov Background: The utility of whole-genome sequencing (WGS) in diagnosing cardiomyopathies (CM) and heritable connective tissue disorders (HCTD) is limited by high costs and ambiguous results. Letting the referring physician decide whom to refer for WGS increases the absolute number of positive patients identified but lowers clinical yield (proportion of patients identified with a pathogenic gene var

Background: Malignant hyperthermia (MH) susceptibility is associated with variants in RYR1, the gene encoding the skeletal muscle ryanodine receptor-1 (RyR1), in 70–75% of patients. Functional characterisation demonstrating an increased sensitivity to RyR1 agonists is necessary among other criteria for inclusion in the European Malignant Hyperthermia Group list of MH susceptibility diagnostic vari

Land use/vegetation cover change, reflecting a range of human land use practices, is the most prevalent and immediate influence on alterations in soil quality. The physical structure of soil is crucial for safeguarding soil carbon (C) and nitrogen (N), as it modulates the physical protection mechanisms and the distribution of these elements within the soil. Nevertheless, the impact of soil physica

This article presents new estimates of the material living standards among the rural population in southern Sweden from the 1670s up to 1865. The development of rural consumer patterns over the period is analyzed using a newly constructed database of 1665 probate inventories from three benchmark periods. It finds that that all rural households, no matter their socioeconomic status, diversified theThis article presents new estimates of the material living standards among the rural population in southern Sweden from the 1670s up to 1865. The development of rural consumer patterns over the period is analyzed using a newly constructed database of 1665 probate inventories from three benchmark periods. It finds that that all rural households, no matter their socioeconomic status, diversified the

Background: Problem gambling and gambling disorder cause severe social, psychiatric, and financial consequences, and voluntary self-exclusion is a common harm reduction tool used by individuals with gambling problems. Objective: The aim of this study was to explore users’ experience of a novel nationwide, multioperator gambling self-exclusion service, “Spelpaus,” in Sweden and to inform stakeholde

ObjectivesTo investigate bone mineral density (BMD), osteoporosis prevalence and SSc-specific associations of BMD in SSc patients compared with background population.MethodsIn total, 211 SSc patients (182 women, 29 men; mean age 61.3 and 62.2 years, respectively) and 505 age- and sex-matched controls from the same geographic area participated. BMD and T-score at total hip and lumbar spine was meas

Objective: The primary aim was to identify radiomics ultrasound features that can distinguish between benign and malignant adnexal masses with solid ultrasound morphology, and between primary malignant (including borderline and primary invasive) and metastatic solid ovarian masses, and to develop ultrasound-based machine learning models that include radiomics features to discriminate between benig

This study develops a strategic framework to guide the adoption of Industry 4.0 technologies across various business sectors. Using a mixed-methods approach, the research combines an extensive literature review with empirical investigations, including case studies and surveys with industry practitioners. The framework integrates advanced digital technologies, such as artificial intelligence and im

Recombinant adeno-associated virus (rAAV) has emerged as an attractive gene delivery vector platform to treat both rare and pervasive diseases. With more and more rAAV-based therapies entering late-stage clinical trials and commercialization, there is an increasing pressure on the rAAV manufacturing process to accelerate drug development, account for larger trials, and commercially provide high do

Kroppen har relevans för psykologi. Den är basen, alltid i bakgrunden av våra upplevelser, våra sinnestillstånd, och den är därmed alltid med i bakgrunden av psykopatologiska tillstånd. En bättre förståelse för kroppens betydelse för vår tillvaro och vårt varande är en första utgångspunkt. Ett huvudargument som förs i avhandlingen är att om psykopatologiska tillstånd som berör ens kroppslighet skaThe body holds relevance for psychology. The body is the basis, always in the background of our experiences, our states of mind, and therefore always in the background of psychopathological conditions.A better understanding of the body's significance is a first starting point. A main argument made in the thesis is that if we sincerely want to understand psychopathological states we need some basic

For decades, extensive surfactant libraries have been developed to meet the requirements of downstream applications. However, achieving functional diversity has traditionally demanded a vast array of chemical motifs and synthetic pathways. Herein, a new approach for surfactant design based on structural isomerism is utilised to access a wide spectrum of functionalities. A library of C18-aliphatic

Entrepreneurial initiatives aiming to transform organizations from the bottom up are often complicit with the power structures they seek to change, reproducing the old while trying to cultivate the new. To unleash the transformative potential of these initiatives, it is crucial to better understand how workers can productively reckon with complicity and how this reckoning drives the entrepreneuria

At the core of this artistic research project is the idea that composing music can entail more than structuring sonic material; it may involve constructing the very space in which musical thoughts take shape. This space, the composable, is understood not as a fixed, pre-existing framework but as a space in flux—shaped by instruments, devices, spatial configurations, and performative gestures—where

Audio description (AD) serves as a vital means to make visual media accessible to non-sighted and visually impaired audiences. This study systematically investigates the impact of narrative specificity and voice quality on imageability and comprehension in both sighted and non-sighted populations. Twenty non-sighted participants, including congenitally blind individuals and those who lost their si

Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).