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Kartläggning av svensk FoU inom området IT och miljö

Swedish R&D activities in the field of IT and the environment - a mapping related to indirect environmental effects and effects at system level Feb 2009: Peter Arnfalk, Andrius Plepys, Chris van Rossem, The International Institute for Industrial Environmental Economics, Lund University. The International Institute for Industrial Environmental Economics (IIIEE) at Lund University has, in autumn

Food intake and meal pattern in IAPP knockout mice with and without infusion of exogenous IAPP

Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT) mice for 27 weeks. In an additional short-term experiment, IAPP (25 pmol . kg(-1)min(-1)) was infused subcutaneously for 3 days in KO and WT mic

Distribution of reaction products in phospholipase A(2) hydrolysis

We have monitored the composition of supported phospholipid bilayers during phospholipase A(2) hydrolysis using specular neutron reflection and ellipsometry. Porcine pancreatic PLA(2) shows along lag phase of several hours during which the enzyme binds to the bilayer surface, but only 5 +/- 3% of the lipids react before the onset of rapid hydrolysis. The amount of PLA(2), which resides in a 21 +/-

Dynamics of protein and peptide hydration

Biological processes often involve the surfaces of proteins, where the structural and dynamic properties of the aqueous solvent are modified. Information about the dynamics of protein hydration can be obtained by measuring the magnetic relaxation dispersion (MRD) of the water 2 H and 17 0 nuclei or by recording the nuclear Overhauser effect (NOE) between water and protein protons. Here, we use the

Highly diastereoselective hydrogenations leading to ß-hydroxy ∂-lactones in hydroxy-protected form. A modified view of ∂-lactone conformations.

Enol MEM ethers 4 and 15 and the corresponding enol acetates were hydrogenated over Pd/C with very high (>99%) diastereoselectivity to saturated -lactones. A stereochemical generalization can be formulated thus: trans-5,6-disubstituted 1-oxa-3-cyclohexen-2-ones (e.g. 14 and 15) are hydrogenated over Pd with high selectivity from the side trans to the C(6)-substituent. A mechanistic rationalization

Mixed solutions of hydrophobically modified graft and block copolymers

Phase separation temperatures and viscosities of dilute and semidilute aqueous mixtures of hydrophobically modified graft and block copolymers have been studied. The graft copolymer was hydrophobically modified ethyl(hydroxyethyl)cellulose (HM-EHEC), and the block copolymers were hydrophobically modified poly(ethylene glycol) (HM-PEG) with diblock (DB) or triblock (TB) structures, i.e., modified a

Individualized low-dose growth hormone (GH) treatment in GH-deficient adults with childhood-onset disease: metabolic effects during fasting and hypoglycemia

Growth hormone (GH) has insulin-antagonistic effects, and GH secretion is augmented during fasting and hypoglycemia. In the present study, 10 patients aged 21 to 28 years with childhood-onset GH deficiency (GHD) were studied during a 24-hour fast and a hypoglycemic glucose clamp before and after 9 months of GH replacement. During the 24-hour fast, blood glucose, serum insulin, and serum free fatty

Young today-adult tomorrow! Studies on physical status, physical activity, attitudes, and self-perception in children and adolescents

The aim was to gain knowledge of young people's physical status and physical activity, and to further the understanding of the role of school physical education in a salutogenic public health perspective. Two studies were performed in southern Sweden. Study 1 was performed in 1996 among 301 adolescents aged 16-19 in upper secondary school. It comprised three parts: a questionnaire, seven physical

Knee arthroplasty in rheumatoid arthritis. A report from the Swedish Knee Arthroplasty Register on 4,381 primary operations 1985-1995

The Swedish Knee Arthroplasty Register has data on 4,381 primary operations performed 1985-1995 for rheumatoid arthritis. Of these, 192 were performed with unicompartmental prostheses and 4143 with tricompartmental. 77% were women and the mean age was 66 years. There were 126 first, 20 second, and 1 third revision in tricompartmental arthroplasties, mainly for loosening, infection and patellar pro

Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes

Previous studies have shown that when bovine mitochondrial elongation factor Ts (EF-Ts) is expressed in Escherichia coli, it forms a tightly associated complex with E. coli elongation factor Tu (EF-Tu). In contrast to earlier experiments, purification of free mitochondrial EF-Ts was accomplished under nondenaturing conditions since only about 60% of the expressed EF-Ts copurified with E. coli EF-T

Class dependent cluster refinement

Unsupervised classification is a very common problem in pattern recognition even when the classes are known. In many areas intra-class variations may be greater than the inter-class variations causing a need for a subdivision of the training set of a class into smaller subunits often referred to as clusters. The subdivision or clustering is often performed independently of the relative properties

OSL chronology for a sediment core from the southern Baltic Sea: A continuous sedimentation record since deglaciation

A chronology based on optically stimulated luminescence (OSL) dating is presented for the late- and post-glacial evolution of the southern Baltic Sea (-15ka to present). During this period, large water level and salinity changes occurred in the Baltic Basin due to opening and closing of connections to the North Atlantic. Previous attempts to establish a chronology for these palaeoenvironmental cha

Shining lights or lone wolves? Creativity and self-image in primary school children

The relationship between self-image and creativity was studied in primary school children. Earlier research points in two directions. Some researchers describe the creative child as well adjusted. Others provide a more nuanced picture in which less well-behaved children can also be creative. Three different measures of creativity were used in this study: the Unusual Uses Test, an activity question