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Multiple-quantum spin relaxation is a sensitive probe for correlated conformational exchange dynamics on microsecond to millisecond time scales in biomolecules. We measured differential H-1-N-15 multiple-quantum relaxation rates for the backbone amide groups of the E140Q mutant of the C-terminal domain of calmodulin at three static magnetic field strengths. The differential multiple-quantum relaxa
The use of low emissivity windows degrades radio communication. This Communication presents design, manufacturing, and test measurements for an energy saving window that is transparent to GSM, GPS, and 3G radio wave frequencies. A frequency selective structure (FSS) is used in the metallic coating of the window to provide the desirable transparency in the frequency range from 900 MHz to 2 GHz. The
A total of six high-resolution FT-IR spectra for trans-glyoxal-d(2), trans-glyoxal-d(1) and trans-glyoxal-C-13(2) were recorded with a resolution ranging from 0.003 to 0.004 cm(-1). By means of a simultaneous ground state combination difference analysis for each of these isotopologues using the Watson Hamiltonian in A-reduction and I-r-representation the ground state rotational constants are obtai
Background: The peptide CART is widely expressed in central and peripheral neurons, as well as in endocrine cells. Known peripheral sites of expression include the gastrointestinal (GI) tract, the pancreas, and the adrenal glands. In rodent pancreas CART is expressed both in islet endocrine cells and in nerve fibers, some of which innervate the islets. Recent data show that CART is a regulator of
Biblioteksbarometern 2005 är en utvärdering av Lunds Universitets Bibliotek. Hur nöjda är studenter, doktorander och lärare med de traditionella bibliotekstjänsterna och de digitala?
Gene-environment interactions include exposure to genotoxic compounds from our diet and it is no doubt, that humans are regularly exposed to e.g. food toxicants, not least from cooked foods. This paper reviews briefly four classes of cooked food toxicants, e.g. acrylamide, heterocyclic amines, nitrosamines and polyaromatic hydrocarbons. Many of these compounds have been recognised for decades also
Capacitance measurements were applied to mouse pancreatic beta-cells to elucidate the cellular mechanisms underlying biphasic insulin secretion. We report here that only <50 of the beta-cell's >10,000 granules are immediately available for release. The releasable granules tightly associate with the voltage-gated alpha(1C) Ca(2+) channels, and it is proposed that the release of these granules accou
Transplantation of embryonic nigral tissue ameliorates functional deficiencies in Parkinson disease. The main practical constraints of neural grafting are the shortage of human donor tissue and the poor survival of dopaminergic neurons grafted into patients, which is estimated at 5-10% (refs. 3,4). The required amount of human tissue could be considerably reduced if the neuronal survival was augme
Ripley's K-function was used to investigate the changes in spatial pattern among trees in a semi-natural mixed deciduous forest in Denmark over 50 years, from 1948 to 2001. Trees larger than 10 cm diameter in breast height (dbh) were mapped at 10-year intervals in 16 blocks within two former compartments. At the start of the observation, trees were found to be regularly distributed at distances le
The influence of footwear insulation on foot skin temperature in the cold at low activity was investigated. Simultaneously, the thermal and pain sensations, and the influence of steel toe cap were studied. Eight subjects were exposed for 85 minutes to three environmental temperatures (+3; -12 and -25 °C) wearing 5 different boots. Insulation of footwear was determined with a thermal foot model. Th
Homogeneous Charge Compression Ignition (HCCI) holds great promises for good fuel economy and low emissions of NOdx and soot. The concept of HCCI is premixed combustion of a highly diluted mixture. The dilution limits the combustion temperature and thus prevents extensive NOdx production. Load is controlled by altering the quality of the charge, rather than the quantity. No throttling together wit
In wireless communications, stationary terminal scenarios are becoming increasingly important as bitrates goes up. Consequently, the need to improve the knowledge about the channel behavior and to develop realistic channel models for these scenarios is also increasing. The present work comprises both measurements and modeling of the radio channel when the terminal is stationary. The measurements w
Five to 15% of patients with primary sclerosing cholangitis (PSC) develop cholangiocarcinoma (CC) with a median survival of 5 to 7 months, an outcome not significantly improved by liver transplantation. However, if CC is found incidentally during the procedure or in the explanted liver, 5-year survival rates of 35% are reported. A noninvasive method to detect CC small enough to allow for intended
