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Emerging role of SOX11 in mantle cell lymphoma

During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can inte

Integration studies on a two-stage fermentation process for the production of biohydrogen

Fermentation of biomass residues and second generation biomasses is potentially a way to enable a sustainable production of hydrogen. Simulation models which calculate mass and energy balances, developed with Aspen Plus (R), are used to integrate the process steps necessary to produce pure hydrogen from biomass in a 2-stage fermentation process. Process and heat integration are introduced to reduc

I stadens skugga : den medeltida landsbygden som arkeologiskt forskningsfält

In this thesis focus is on two aims: 1) to investigate the emergence and establishment of medieval rural archaeology as an archaeological field of study, from the 1930’s up until today and 2) based on the results made in this study, to discuss generally how new subject areas are incorporated and maintained within the humanities. Thus, the scope of the thesis does not lie on the medieval period wit

Soil disturbance as a grassland restoration measure-effects on plant species composition and plant functional traits.

Soil disturbance is recognized as an important driver of biodiversity in dry grasslands, and can therefore be implemented as a restoration measure. However, because community re-assembly following disturbance includes stochastic processes, a focus only on species richness or establishment success of particular species will not inform on how plant communities respond ecologically to disturbance. We

Brain Activity in Predictive Sensorimotor Control for Landings: an EEG Pilot Study

Landing from a jump is related to predictive sensorimotor control. Frontal, central and parietal brain areas are known to play a role in this process based on online sensory feedback. This can be measured by EEG. However, there is only limited knowledge about brain activity during predictive preparation for drop landings (DL). The purpose is to demonstrate changes in brain activity in preparation

Pain, power and patience - A narrative study of general practitioners' relations with chronic pain patients

Background: Chronic pain patients are common in general practice. In this study "chronic pain" is defined as diffuse musculoskeletal pain not due to inflammatory diseases or cancer. Effective patient-physician relations improve treatment results. The relationship between doctors and chronic pain patients is often dysfunctional. Consultation training for physicians and medical students can improve

Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array-comparative genomic hybridization

We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative

Effects of water gradients and use of urea on skin ultrastructure evaluated by confocal Raman microspectroscopy.

The rather thin outermost layer of the mammalian skin, stratum corneum (SC), is a complex biomembrane which separates the water rich inside of the body from the dry outside. The skin surface can be exposed to rather extreme variations in ambient conditions (e.g. water activity, temperature and pH), with potential effects on the barrier function. Increased understanding of how the barrier is affect

Phylogeography and conservation genetics of the common wall lizard, Podarcis muralis, on islands at its northern range.

Populations at range limits are often characterized by lower genetic diversity, increased genetic isolation and differentiation relative to populations at the core of geographical ranges. Furthermore, it is increasingly recognized that populations situated at range limits might be the result of human introductions rather than natural dispersal. It is therefore important to document the origin and

The role of seniority-zero states in nuclear level densities

At low excitation energies seniority-zero states dominate the level density of K = 0 bands in deformed even even nuclei, while they play no role at higher excitation energies. We describe the level densities in a Fermi-gas model as well as in a combinatorial level-density model and compare to detailed experimental data for some rare-earth nuclei. An explanation is provided for recent observations

Flame Spread Modelling of Complex Textile Materials

Flame spread in textile materials was modelled using two different simulation programs: the semi-empirical area-based code ConeTools, and the computational fluid dynamics, CFD, code Fire Dynamics Simulator, FDS, (version 5). Two textile products developed within the EU-project Flexifunbar were selected for study. The two products show a large difference in composition and application area, one mat

A critical literature review of moisture and temperature conditions in wood exposed outdoors above ground

Summary In the majority of the field studies reviewed in this report samples were exposed outdoors above ground and only the average moisture content was determined. Therefore, no information is given about the moisture content in joints and other moisture traps. In many of the field studies, information on relative humidity, temperature, rainfalls etc. is missing and consequently these field stud