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Effect of Heat Treatment on Bovine β Lactoglobulin A, B and C. Explored Using Thiol Availability and Fluorescence.

Dilute solutions of -lactoglobulin (-Lg) A, B, and C were heated at temperatures between about 40 and 94 C for 10 min, cooled, and analyzed using Trp fluorescence and extrinsic fluorescence spectra of the probe 1,8-anilinonaphthalene sulfonate (ANS). Thiol availabilities using 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) were determined using a separate set of samples. The normalized ANS fluorescenc

On future non-medical costs in economic evaluations

Economic evaluation in health care is still an evolving discipline. One of the current controversies in cost-effectiveness analysis regards the inclusion or exclusion of future non-medical costs (i.e. consumption net of production) due to increased survival. This paper examines the implications of a symmetry rule stating that there should be consistency between costs included in the numerator and

Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells

The Wnt-5a gene encodes a secreted protein that controls several normal processes during embryogenesis and development of adult tissues by as yet unknown mechanisms. Endogenous expression of Wnt-5a mRNA is known to occur in both mouse and human mammary cell lines. To investigate the biological role of Wnt-5a in the human mammary epithelial cell line HB2, we used an antisense approach to repress en

Memory bias for faces that are perceived as hostile by crime victims with acute posttraumatic stress disorder (PTSD)

The present study tested, and found support for, the hypotheses that crime victims with acute post-traumatic stress disorder have: (1) a general memory impairment for faces; and (ii) a memory bias for faces that they perceive as hostile, even when these faces are not arranged to show any hostile face expressions. It is suggested that crime victims with acute post-traumatic stress disorder perform

Interaction of Nanometric Clay Platelets

The free energy of interaction between two nanometric clay platelets immersed in an electrolyte solution has been calculated using Monte Carlo simulations as well as direct integration of the configurational integral. Each platelet has been modeled as a collection of charged spheres carrying a unit charge-the face of a platelet contains negative charges, and the edge, positive charges. The calcula

Outcomes of preterm children according to type of delivery onset: a nationwide population-based study

The objective of the study was to investigate whether spontaneous and iatrogenic preterm births are associated with different paediatric outcomes. A nationwide population-based study comprising 1 010 487 singletons used data from 1991 to 2001 from the Swedish Medical Birth Register and the Swedish Hospital Discharge Register. Intrauterine fetal deaths, unknown type of delivery onset and congenital

Association of insulin-like growth factor-1 receptor polymorphism in dementia

There is an increasing interest in how oxidative stress can cause cells to go into apoptosis in both normal ageing and in neurodegenerative disorders. Previous research has implicated insulin-like growth factor-1 (IGF-1) as being involved in the pathogenesis in Alzheimer's disease (AD) by protecting the neurons through reducing neuronal susceptibility to oxidative stress. IGF-1 receptor (IGF-1R) p

Measurement of transverse single-spin asymmetries for midrapidity production of neutral pions and charged hadrons in polarized p+p collisions at root s=200 GeV

Transverse single-spin asymmetries to probe the transverse-spin structure of the proton have been measured for neutral pions and nonidentified charged hadrons from polarized proton-proton collisions at midrapidity and root s = 200 GeV. The data cover a transverse momentum (pT) range 1.0-5.0 GeV/c for neutral pions and 0.5-5.0 GeV/c for charged hadrons, at a Feynman-x value of approximately zero. T

Microchip immobilized enzyme reactors for hydrolysis of methyl cellulose

Microchip immobilized enzyme reactors (mu IMERs) with immobilized endoglucanases were applied for the hydrolysis of methyl cellulose (MC). MCs of various molecular weights were hydrolyzed using two mu IMERs containing immobilized celloendoglucanase Cel 5A from Bacillus agaradhaerens (BaCel 5A) connected in series. Hydrolysis by the mu IMER could be confirmed from the average molar masses and molar

Test processes in software product evolution - a qualitative survey on the state of practice

In order to understand the state of test process practices in the software industry, we have conducted a qualitative survey, covering software development departments at 11 companies in Sweden of different sizes and application domains. The companies develop products in an evolutionary manner, which means either new versions are released regularly, or new product variants under new names are relea

HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy

New cancer treatments should aim to destroy tumor cells without disturbing normal tissue. HAMLET (human a-lactalbumin made lethal to tumor cells) offers a new molecular approach to solving this problem, because it induces apoptosis in tumor cells but leaves normal differentiated cells unaffected. After partial unfolding and binding to oleic acid, α-lactalbumin forms the HAMLET complex, which enter

Histopathological classification of lung cancer: relevance of cytokeratin and TTF-1 immunophenotyping

istopathologic classification of lung carcinoma is important, as a prognostic factor and in the evaluation of treatment modalities. Although the World Health Organization classification of lung cancer is based on routine microscopy, immunohistochemistry is an important additional aspect in modern pathologic practice. This study examines whether the main histologic types of lung carcinomas are more

The lobate and subfruticose species of Caloplaca in North and Central America.

This paper includes 19 saxicolous species of Caloplaca from North and Central America that are characterized by distinctive elongated marginal lobes, non-paraplectenchymatous hypothecium, and presence of anthraquinones. In various ways this group has been referred to as Caloplaca section Gasparrinia or even separated at the generic level. The group, however, is not regarded as natural and conseque

Early identification of acute myocardial infarction by activated protein C-protein C inhibitor complex.

Introduction: Increased coagulation activity due to coronary thrombosis in a ruptured plaque should result in activation of the protein C anticoagulant system with formation of complexes between activated protein C (APC) and,the protein C inhibitor (PCI), which reflects coagulation activity. We hypothesized that elevated APC-PCI concentration might allow earlier detection of ongoing myocardial inf

5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries

STUDY OBJECTIVE--The aim of the study was to investigate the receptor events that mediate the vascular effects of 5-hydroxytryptamine (5-HT) on human coronary arteries, since 5-HT has long been thought to play a role in coronary artery vasospasm. DESIGN--Recently available selective receptor agonists and antagonists were used to examine the 5-HT receptor subtypes present in human epicardial corona

Who speaks? And who listens? The relationship between planners and women’s participation in local planning in a multi-cultural urban environment

In recent decades, the dominant planning discourse has undergone a great change from a previous top-down approach towards collaborative and communicative planning. Instead of merely planning for the people in a technocratic and positivist approach, planners are increasingly expected to pay attention to the voices of the citizens. However, within this new participatory approach there is a growing p

Consistent and contrasting decadal Arctic sea ice thickness predictions from a highly optimized sea ice model

Decadal hindcast simulations of Arctic Ocean sea ice thickness made by a modern dynamic-thermodynamic sea ice model and forced independently by both the ERA-40 and NCEP/NCAR reanalysis data sets are compared for the first time. Using comprehensive data sets of observations made between 1979 and 2001 of sea ice thickness, draft, extent, and speeds, we find that it is possible to tune model paramete