Filtyp
Cyclophilin D (CypD) is a mitochondrial matrix protein implicated in cell death, but a potential role in bioenergetics is not understood. Here, we show that loss or depletion of CypD in cell lines and mice induces defects in mitochondrial bioenergetics due to impaired fatty acid β-oxidation. In turn, CypD loss triggers a global compensatory shift towards glycolysis, with transcriptional upregulati
BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms.METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultures (from five patient samples), three glioblastoma (GBM) tumor cell lines, and an intracranial model
Background: Depending on the definitions used, between 5 and 20 % of all Swedish children grow up with at least one parent suffering from alcohol problems, while 6 % have at least one parent who has received inpatient psychiatric care, conditions that may affect the children negatively. Nine out of ten Swedish municipalities therefore provide support resources, but less than 2 % of these children
This paper aims to analyze whether patients should be allowed to veto research-related use of medical data collected during routine follow-ups after their withdrawal from first-in-human clinical trials. Forms of withdrawal are identified and it is argued that the right to withdraw might be limited to some of these. The paper concludes that if veto right is denied, then: the research participant sh
PurposeThe location of a logistics facility is strategic decision, impacting distribution cost, efficiency and environmental impact. The purpose of this paper is to systemize existing knowledge by a literature review. Based on the literature review we propose a framework in this area of theoretical and practical relevance.Design/methodology/approachWe have examined the peer-reviewed literature on
In the contemporary dual crisis, economic crisis policies cannot be dealt with in isolation from the rampant and acute ecological crisis – and vice versa. In this article, we challenge the hegemonic positions in purported attempts to solve the crises so far: in the economic realm, the Keynesian episode of 2008–2009 as well as austerity policies, and with regard to the ecological crisis, ecologicalIn the contemporary dual crisis, economic crisis policies cannot be dealt with in isolation from the rampant and acute ecological crisis – and vice versa. In this article, we challenge the hegemonic positions in purported attempts to solve the crises so far: in the economic realm, the Keynesian episode of 2008–2009 as well as austerity policies, and with regard to the ecological crisis, ecological
The analysis of the angle dependence of the elastic scattering of radiation from a sample is an efficient and non-invasive technique that is used in fundamental science, in medicine and in technical quality control in industry. Precise information on the shape, size, polydispersity and interactions of a colloidal sample is readily obtained provided an underlying scattering model, i.e. form and str
Measures of three-dimensional spatial wave size are proposed and expressed in terms of properly defined characteristics: the crest-height, the length, and the wave front location. Their statistical distributions are presented in explicit integral forms for the deep water seas modeled as Gaussian fields. The proposed approach allows for investigation of the effect that shape and directionality of t
The term ‘Green Energy Economy’ (GEE) received increasing policy and scientific attention following the 2008–2009 global financial crisis, leading to the implementation of numerous ‘Green Growth’ economic stimulus packages that targeted low-carbon energy technologies. These initiatives were portrayed as key elements in the transition to a green economy, in which low-carbon energy systems would pla
