BACKGROUND: Cathelicidins are a group of antibiotic peptides with broad antimicrobial activity. They are considered to be an essential part of the innate immune system. The only known human cathelicidin is the human cationic antimicrobial protein (hCAP-18), from which the antimicrobial peptide LL-37 is released. METHODS AND RESULTS: In the present study, we purified hCAP-18 from seminal plasma and

Lentiviral vectors containing recombinant envelope proteins that target hematopoietic stem cells have now been engineered to increase the efficiency of gene transfer.

OBJECTIVE: Coronary artery disease is a prevalent cause of morbidity and mortality in diabetes. Little is known about insulin-like growth factor-I receptors (IGF-IR) and insulin receptors (IR) in human coronary endothelium. Our aim was to characterize IGF-IR and IR in human coronary artery endothelial cells (HCAEC). DESIGN: Cultured human coronary artery endothelial cells were used. Gene expressio

The impact of the optical properties on the annual performance of flat plate collectors in a Swedish climate has been estimated with the MINSUN program. The collector parameters were determined with a theoretically based calculation program verified from laboratory measurements. The importance of changes in solar absorptance and thermal emittance of the absorber, the addition of a teflon film or a

Arbuscular mycorrhizal (AM) cucumber seedlings and uncolonized controls were grown in growth chambers which allowed separation of compartments with roots from compartments with the extraradical mycelium alone. Two fungi, Glomus invermaium Hall and G. caledonium (Nicol. and Gerd.) Trappe and Gerdemann, were used. Bacterial numbers (direct and viable count) and activities (thymidine incorporation) w

The results of a study on the phase behavior of the monoolein/water system with the addition of the hydrocarbon 1,8-cineole (C10H18O) and supercritical carbon dioxide at 15 MPa is presented. To two mixtures consisting of 9 and 18 wt.% water in monoolein, 5, 10, and 20 wt.% cineole were added and heated to between 35 and 80 degreesC at atmospheric pressure and in the presence of supercritical carbo

Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with R

This paper presents a novel tool to be used for signature verification. The method is based on the vector context matrix concept that enables robust and precise extraction of the point correspondences between a sample and a database model. Using a digitizing tablet as a source for input, information of the pressure, speed and pen inclination is obtained in addition to the coordinates of the sample

TCR signaling is mediated by intracellular signaling molecules and nuclear transcription factors, which are tightly regulated by interaction with regulatory proteins such as Grb2 and SLAP. We reported recently that TCR stimulation induces the expression of cytokine-induced SH2 protein (CIS). The expression of CIS promotes TCR-mediated activation. We have now found specific interactions between CIS

Sample preparation effects in matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOFMS) of partially depolymerised carboxymethyl cellulose (CMC) have been investigated. The depolymerisation was either enzymatic or acidic. Fractions of enzymatically depolymerised CMC were collected from size-exclusion chromatography (SEC) and further investigated by MALDI-TOFMS. 2,5

The initial stages of the formation of SBA-15 have been studied by in situ SAXS/XRD using synchrotron radiation. Modeling of both the diffuse scattering and the X-ray diffraction patterns obtained at different stages of the reaction results in a detailed description of the different reaction steps. The first step in the formation is the liquid-liquid phase separation of spherical P123-silicate hyb

Motivation: The above-ground tissues of higher plants are generated from a small region of cells situated at the plant apex called the shoot apical meristem. An important genetic control circuit modulating the size of the Arabidopsis thaliana meristem is a feed-back network between the CLAVATA3 and WUSCHEL genes. Although the expression patterns for these genes do not overlap, WUSCHEL activity is

Follicular lymphoma (FL) frequently transforms into the more aggressive diffuse large B cell lymphoma (DLBCL-tr), but no protein biomarkers have been identified for predictive or early diagnosis. Gene expression analyses have identified genes changing on transformation but have failed to be reproducible in different studies, reflecting the heterogeneity within the tumor tissue and between tumor sa